P.0437 Memory enhancing effect after medial septum stimulation is associated with changes in hippocampal receptors expression in naturally-aged rats

2021 ◽  
Vol 53 ◽  
pp. S318
Author(s):  
M. Burjanadze ◽  
T. Naneishvili ◽  
G. Beselia ◽  
L. Tsverava ◽  
R. Solomonia
Keyword(s):  
Medial Septum ◽  
Aged Rats ◽  
Enhancing Effect ◽  
Memory Enhancing

scholarly journals Memory enhancing effect of embelin against scopolamine-induced amnesia in Sprague Dawley rats

2016 ◽  
Vol 10 ◽  
Author(s):  
Bhuvanendran Saatheeyavaane ◽  
Kumari Yatinesh ◽  
Othman Lekshan ◽  
Shaikh Mohd
Keyword(s):  
Sprague Dawley ◽  
Enhancing Effect ◽  
Sprague Dawley Rats ◽  
Memory Enhancing

Dammarane triterpenoid saponins from Bacopa monnieri

2009 ◽  
Vol 87 (9) ◽  
pp. 1230-1234 ◽  
Author(s):  
Pamita Bhandari ◽  
Neeraj Kumar ◽  
Bikram Singh ◽  
Inderjeet Kaur
Keyword(s):  
Medicinal Plant ◽  
2D Nmr ◽  
Bacopa Monnieri ◽  
Spectroscopic Methods ◽  
Triterpenoid Saponins ◽  
Enhancing Effect ◽  
Indian Medicinal Plant ◽  
Aerial Parts ◽  
Memory Enhancer ◽  
Memory Enhancing

Bacopa monnieri is a well-known Ayurvedic Indian medicinal plant traditionally used as a memory enhancer. Its memory-enhancing effect is mainly attributed to dammarane triterpenoid saponins. In the present study, two new dammarane-type triterpenoid saponins, bacopaside-XI (1) and bacopaside-XII (2), together with known compounds, bacopaside IV, bacopaside V, and apigenin, were isolated from the aerial parts of the B. monnieri . The structures of the new saponins were elucidated as 3-O-[α-L-arabinofuranosyl(1→3)]-6-O-sulfonyl-β-D-glucopyranosyl pseudojujubogenin (1) and 3-O-{β-D-glucopyranosyl(1→3)[α-L-arabinofuranosyl(1→2)]-β-D-glucopyranosyl}-20-O-α-L-arabinopyranosyl pseudojujubogenin (2) on the basis of extensive investigations of 1D and 2D NMR (HMQC and HMBC), ESI-QTOF-MS/MS spectroscopic methods, and chemical evidences.

First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice

Neuroreport ◽  
2001 ◽  
Vol 12 (2) ◽  
pp. 375-378 ◽  
Author(s):  
Daniel Béracochéa ◽  
Barbara Cagnard ◽  
Aurélie Célérier ◽  
Julie le Merrer ◽  
Michel Pérès ◽  
...  
Keyword(s):  
Working Memory ◽  
Enhancing Effect ◽  
Delay Dependent ◽  
Memory Enhancing

scholarly journals Emotional Nuance Enhances Verbatim Retention of Written Materials

2021 ◽  
Vol 12 ◽  
Author(s):  
Yoonji Kim ◽  
Diana Van Lancker Sidtis ◽  
John J. Sidtis
Keyword(s):  
Emotional Expression ◽  
Verbal Material ◽  
Test Results ◽  
Enhancing Effect ◽  
Emotional Events ◽  
Study Participants ◽  
Written Materials ◽  
Memory Enhancing ◽  
Neutral Expression

Recent studies have demonstrated that details of verbal material are retained in memory. Further, converging evidence points to a memory-enhancing effect of emotion such that memory for emotional events is stronger than memory for neutral events. Building upon this work, it appears likely that verbatim sentence forms will be remembered better when tinged with emotional nuance. Most previous studies have focused on single words. The current study examines the role of emotional nuance in the verbatim retention of longer sentences in written material. In this study, participants silently read transcriptions of spontaneous narratives, half of which had been delivered within a context of emotional expression and the other half with neutral expression. Transcripts were taken from selected narratives that received the highest, most extreme ratings, neutral or emotional. Participants identified written excerpts in a yes/no recognition test. Results revealed that participants’ verbatim memory was significantly greater for excerpts from emotionally nuanced narratives than from neutral narratives. It is concluded that the narratives, pre-rated as emotional or neutral, drove this effect of emotion on verbatim retention. These findings expand a growing body of evidence for a role of emotion in memory, and lend support to episodic theories of language and the constructionist account.

EFFECT OF DROTAVERINE, A PHOSPHODIESTERASE 4 INHIBITOR IN SCOPOLAMINE-INDUCED COGNITIVE IMPAIRMENT IN RATS

2020 ◽  
pp. 99-102
Author(s):  
KAYALVIZHI MK
Keyword(s):  
Smooth Muscle ◽  
Cognitive Impairment ◽  
Learning And Memory ◽  
Neurodegenerative Disorder ◽  
Enhancing Effect ◽  
Group I ◽  
Y Maze ◽  
Significant Difference ◽  
Group Ii ◽  
Memory Enhancing

Objective: Cognitive impairment (CI) is a progressive neurodegenerative disorder and causes significant dementia in the elderly. Intracellular cyclic AMP (cAMP) signaling has been well established in the mediation of memory. Phosphodiesterases (PDEs) are enzymes that catalyze the hydrolysis of cAMP and/or cyclic GMP. Drotaverine is a novel non-anticholinergic smooth muscle antispasmodic which acts by inhibiting PDE-4. It is now clinically used in smooth muscle spasms (intestinal, biliary and renal colic, irritable bowel syndrome, uterine spasms, etc.) without anticholinergic side effects. Since Drotaverine has PDE4 inhibition property, its role in learning and memory was evaluated in this study and found that it has memory enhancing effect comparable with donepezil in scopolamine-induced CI in rats. Methods: Learning and memory were assessed with two behavioral models, namely, elevated plus maze (EPM) and Y maze. CI was produced by scopolamine. Rats were divided into five groups, Group I treated with normal saline, Group II treated with scopolamine, and Groups III, IV, and V were treated with donepezil, Drotaverine, and both, respectively. Results: The result analysis revealed significant differences in transfer latency in EPM performance between Groups III, IV, V and Group II (***p<0.001). The results of spontaneous alternation in Y maze show that there was a significant difference among all the treatments groups (p<0.001). Conclusion: Drotaverine has promising memory enhancing effect in CI induced by scopolamine in rats. Further clinical trials are needed to prove this finding which has been elicited in animal models.

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