Importance of herpes simplex virus in development of infertility in married couples

The article considers the role of herpes simplex viruses of 1st, 2nd types in the development of reproductive disorders in married couples. The clinical example shows the difficulties of diagnosis, possible errors in treatment approaches, and the lack of results from the use of artificial insemination methods in the presence of persistent herpetic infection. Prolonged antiviral therapy led to the onset of pregnancy and the birth of a child.

Congenital herpes simpleх: modern approach to prevention, diagnosis, and treatment

Among the classic pathogens of congenital infection, herpes simplex viruses type 1 and type 2 play important role. Neonatal herpes develops as a result of antenatal transmission of HSV. The greatest risk occurs with the primary infection of a woman in the late stages of pregnancy. In 85% of cases, genital and neonatal herpes is associated with HSV-2.The purpose of study: to identify the relationship between early manifestations of neonatal herpes and genital herpes during pregnancy for early diagnosis and etiological therapy of the newborn.Materials and methods. The analysis of current clinical recommendations and international consensuses of professional communities in Russia, the USA, and a number of European countries in the management of pregnant women was carried out. The five medical histories of newborn infants with a diagnosis of congenital herpetic infection were analyzed. In the clinical guidelines for the management of normal pregnancy, routine screening of pregnant women for HSV is omitted, however, examination is recommended for symptoms of genital herpes. For the prevention of neonatal herpes, antiviral drugs and caesarean section are used. Congenital herpes develops rarely, proceeds severely with significant residual manifestations in children. Antiviral therapy (Acyclovir) is used for herpetic infection in newborns: with systemic and local infection (eye damage). The analysis showed: despite the recurrent course of genital herpes in 4 out of 5 women during pregnancy, none of the pregnant women had a laboratory examination for HSV, pregnant women did not receive systemic etiological therapy and all deliveries were natural. The absence of preventive measures contributed to the early, during the first three days of life, the development of severe forms of neonatal herpes. In respect that the lack of significant clinical specificity and delayed manifestation, an antenatal anamnesis is important diagnostic criterion for neonatal herpes.

Ophthalmic manifestations of herpes virus infection in dogs

This article describes the main aspects of the epizootology and pathogenesis of Cahv-1 (canine herpesvirus), also, the clinical forms of manifestations of pathology in dogs of different ages and physiological status are described. Particular attention is paid to ocular pathologies developing at Cahv-1, such as herpetic conjunctivitis, blepharitis, ulcerative and stromal keratitis. The features of the diagnosis and differentiation of these pathologies are described. The systematic and local medicines used by us in the practice of treating dogs with herpetic eye, the principles and algorithms of their prescription are presented. The difficulties of diagnostics Cahv-1 are described, and the reasons for frequent false-negative results during PCR explained in the article. Besides additional laboratory verification methods for Cahv-1 as well as methods of prevention of herpetic infection of dogs are indicated.

THE USE OF ACYCLOVIR, MEDOVIR FOR COMPLEX TREATMENT OF PATIENTS WITH HERPETIC LESIONS OF THE ORAL MUCOSA

Несвоевременная диагностика и отсутствие рациональной терапии герпетической инфекции приводит к хронической сенсибилизации организма, на что указывает увеличение в крови у этих больных титра антител против в ируса простого герпеса в 5-9 раз.Причиной развития герпетической инфекции является вирус простого герпеса, который после попадания в организм человека может вызывать поражения кожи, глаз, слизистых оболочек, нервной системы, сердечнососудистой системы. Поэтому, как могут быть многоликими проявления герпетической инфекции герпеса.Выводы: После аппликации препаратами эрозивные элементы эпителизировались в течение 4 дней, а в контрольной группе эпителий формировался в течение 8 дней. В течение 3 месяцев под наблюдением у этих больных рецидив заболевания не наблюдался, ИФА была выявлена путем обследования титр Ig G снижен в 2,75 раза.Вместе с тем улучшилось общее состояние больных, сократился и период подписки патологических элементов, удлинился период ремиссии и у больных улучшилось настроение, повысилась жизнелюбие, повысилась мотивация к работе. Untimely diagnosis and lack of rational treatment of herpes infection leads to chronic sensitization of the body, as indicated by an increase in the blood titer of antibodies against herpes simplex virus in these patients by 5-9 times.The cause of the development of herpetic infection is the herpes simplex virus, which, after entering the human body, can cause damage to the skin, eyes, mucous membranes, nervous system, and cardiovascular system. Therefore, how can there be many manifestations of herpes infection herpes.Results and conclusions: After application with drugs, erosive elements were epithelized for 4 days, and in the control group, epithelium was formed for 8 days.For 3 months of observation, there was no relapse of the disease in these patients, Elisa was detected by examination it was noted that the IG G titer decreased by 2.75 times.At the same time, the general condition of patients has improved, the period of recovery of pathological elements of the USP has also decreased, the period of remission has been extended, and the mood of patients has improved, their enthusiasm for life has increased, and their motivation to work has increased.

Diseases caused by the herpes simplex virus

Herpetic infection is a disease caused by herpes simplex virus types 1 and 2; it belongs to the category of TORCH infections along with toxoplasmosis, rubella and cytomegalovirus. Herpetic infection is widespread, and recently there has been an increase in the number of cases of herpetic lesions detected, which is most likely due to the expansion of the range of diagnostic tests. Herpes simplex virus type 1 most often affects the skin and mucous membranes, type 2 leads to damage to the urogenital tract. The source of infection can be either a sick person or an asymptomatic carrier. This disease can be transmitted by household contact, during sexual intercourse; the «vertical» route of transmission from mother to child is also known. Depending on the extent of the lesion, localized, widespread and generalized forms are distinguished; the course of herpes infection can be acute, subacute and chronic; latent course of the disease is often found. In addition to the skin and mucous membranes, the central nervous system and (less often) internal organs can be affected. A typical clinical manifestation of herpes simplex is small blistering eruptions that appear on the face, mucous membrane of the lips, wings of the nose, ears, limbs, gluteal folds. The eruptions are usually preceded by itching and hyperemia at the site of the lesion. Diagnosis of herpes infection is carried out on the basis of clinical data and laboratory tests of blood or vesicle contents. Treatment of the disease involves the prescription of antiviral drugs, symptomatic agents, and immunocorrective therapy. Complete removal of the virus from the body is usually impossible, but strengthening the defenses and normalizing the lifestyle contribute to a significant decrease in the frequency of possible relapses.

Prevalence of HSV, Varicella-Zoster, CMV, EBV and HPV in the oral cavity and the larynx carcinoma in Iran

Introduction: Viral diseases can have roles in oral cavity and larynx carcinoma. However, the relationship between HPV, herpetic infection and these cancers is not clear. Materials & methods: DNA of tissues from oral and larynx carcinoma was extracted and the presence of HPV, HSV-1, HSV-2, EBV, CMV and Varicella Zoster virus was detected. Results: We detected five HSV-1 in oral cavity cancer and two HSV-1 in larynx carcinoma. Also, four and two HPV-positive in oral cavity and larynx carcinoma were found, respectively. There were five HPV type 18 and one HPV type 31. None of our samples were infected with EBV, CMV, HSV-2 and Varicella Zoster virus. Conclusion: A higher prevalence of HPV and HSV-1 in cancerous tissues in comparison with normal ones was detected.