THE USE OF ACYCLOVIR, MEDOVIR FOR COMPLEX TREATMENT OF PATIENTS WITH HERPETIC LESIONS OF THE ORAL MUCOSA

2021 ◽  
pp. 4-6
Author(s):  
А.Я. Утепова ◽  
З.Н. Досумбекова
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
The Body ◽  
Control Group ◽  
Rational Treatment ◽  
Herpetic Infection ◽  
Herpes Infection ◽  
Mucous Membranes ◽  
Simplex Virus ◽  
Ig G

Несвоевременная диагностика и отсутствие рациональной терапии герпетической инфекции приводит к хронической сенсибилизации организма, на что указывает увеличение в крови у этих больных титра антител против в ируса простого герпеса в 5-9 раз.Причиной развития герпетической инфекции является вирус простого герпеса, который после попадания в организм человека может вызывать поражения кожи, глаз, слизистых оболочек, нервной системы, сердечнососудистой системы. Поэтому, как могут быть многоликими проявления герпетической инфекции герпеса.Выводы: После аппликации препаратами эрозивные элементы эпителизировались в течение 4 дней, а в контрольной группе эпителий формировался в течение 8 дней. В течение 3 месяцев под наблюдением у этих больных рецидив заболевания не наблюдался, ИФА была выявлена путем обследования титр Ig G снижен в 2,75 раза.Вместе с тем улучшилось общее состояние больных, сократился и период подписки патологических элементов, удлинился период ремиссии и у больных улучшилось настроение, повысилась жизнелюбие, повысилась мотивация к работе. Untimely diagnosis and lack of rational treatment of herpes infection leads to chronic sensitization of the body, as indicated by an increase in the blood titer of antibodies against herpes simplex virus in these patients by 5-9 times.The cause of the development of herpetic infection is the herpes simplex virus, which, after entering the human body, can cause damage to the skin, eyes, mucous membranes, nervous system, and cardiovascular system. Therefore, how can there be many manifestations of herpes infection herpes.Results and conclusions: After application with drugs, erosive elements were epithelized for 4 days, and in the control group, epithelium was formed for 8 days.For 3 months of observation, there was no relapse of the disease in these patients, Elisa was detected by examination it was noted that the IG G titer decreased by 2.75 times.At the same time, the general condition of patients has improved, the period of recovery of pathological elements of the USP has also decreased, the period of remission has been extended, and the mood of patients has improved, their enthusiasm for life has increased, and their motivation to work has increased.

Diseases caused by the herpes simplex virus

2021 ◽  
pp. 8-13
Author(s):  
Nataliya Nikolaevna Sakhno
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Asymptomatic Carrier ◽  
Complete Removal ◽  
The Body ◽  
Herpetic Infection ◽  
Herpes Infection ◽  
Route Of Transmission ◽  
Mucous Membranes ◽  
Simplex Virus

Herpetic infection is a disease caused by herpes simplex virus types 1 and 2; it belongs to the category of TORCH infections along with toxoplasmosis, rubella and cytomegalovirus. Herpetic infection is widespread, and recently there has been an increase in the number of cases of herpetic lesions detected, which is most likely due to the expansion of the range of diagnostic tests. Herpes simplex virus type 1 most often affects the skin and mucous membranes, type 2 leads to damage to the urogenital tract. The source of infection can be either a sick person or an asymptomatic carrier. This disease can be transmitted by household contact, during sexual intercourse; the «vertical» route of transmission from mother to child is also known. Depending on the extent of the lesion, localized, widespread and generalized forms are distinguished; the course of herpes infection can be acute, subacute and chronic; latent course of the disease is often found. In addition to the skin and mucous membranes, the central nervous system and (less often) internal organs can be affected. A typical clinical manifestation of herpes simplex is small blistering eruptions that appear on the face, mucous membrane of the lips, wings of the nose, ears, limbs, gluteal folds. The eruptions are usually preceded by itching and hyperemia at the site of the lesion. Diagnosis of herpes infection is carried out on the basis of clinical data and laboratory tests of blood or vesicle contents. Treatment of the disease involves the prescription of antiviral drugs, symptomatic agents, and immunocorrective therapy. Complete removal of the virus from the body is usually impossible, but strengthening the defenses and normalizing the lifestyle contribute to a significant decrease in the frequency of possible relapses.

scholarly journals Plasma Amyloid-β in Relation to Antibodies Against Herpes Simplex Virus, Cytomegalovirus, and Chlamydophila pneumoniae

2021 ◽  
pp. 1-7
Author(s):  
Karin Lopatko Lindman ◽  
Bodil Weidung ◽  
Jan Olsson ◽  
Maria Josefsson ◽  
Anders Johansson ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Antimicrobial Properties ◽  
Amyloid Β ◽  
Chlamydophila Pneumoniae ◽  
Immunosorbent Assays ◽  
Simplex Virus ◽  
Ig G ◽  
Xmap Technology

Background: Amyloid-β (Aβ), the key constituent of Alzheimer’s disease (AD) plaques, has antimicrobial properties. Objective: To investigate the association between plasma Aβ and antibodies against the AD-related pathogens herpes simplex virus (HSV), cytomegalovirus (CMV), and C. pneumoniae. Methods: Plasma from 339 AD cases, obtained on average 9.4 years (±4.00) before diagnosis, and their matched controls were analyzed for Aβ40 and Aβ42 concentrations with Luminex xMAP technology and INNOBIA plasma Aβ-form assays. Enzyme-linked immunosorbent assays were utilized for analyses of anti-HSV immunoglobulin (Ig) G, anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG. Follow-up samples were available for 163 of the cases. Results: Presence and levels of anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG did not correlate with concentrations of Aβ42 or Aβ40 in cases or controls. Conclusion: Levels of plasma Aβ were not associated with antibodies against different AD-related Spathogens.

scholarly journals Immune Response to Herpes Simplex Virus Infection and Vaccine Development

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 302 ◽  
Author(s):  
Anthony C. Ike ◽  
Chisom J. Onu ◽  
Chukwuebuka M. Ononugbo ◽  
Eleazar E. Reward ◽  
Sophia O. Muo
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Viral Infections ◽  
Recombinant Dna ◽  
Vaccine Development ◽  
The Body ◽  
Effective Vaccine ◽  
Subunit Vaccines ◽  
Simplex Virus ◽  
Hsv Infections

Herpes simplex virus (HSV) infections are among the most common viral infections and usually last for a lifetime. The virus can potentially be controlled with vaccines since humans are the only known host. However, despite the development and trial of many vaccines, this has not yet been possible. This is normally attributed to the high latency potential of the virus. Numerous immune cells, particularly the natural killer cells and interferon gamma and pathways that are used by the body to fight HSV infections have been identified. On the other hand, the virus has developed different mechanisms, including using different microRNAs to inhibit apoptosis and autophagy to avoid clearance and aid latency induction. Both traditional and new methods of vaccine development, including the use of live attenuated vaccines, replication incompetent vaccines, subunit vaccines and recombinant DNA vaccines are now being employed to develop an effective vaccine against the virus. We conclude that this review has contributed to a better understanding of the interplay between the immune system and the virus, which is necessary for the development of an effective vaccine against HSV.

scholarly journals Patterns of accumulation of miRNAs encoded by herpes simplex virus during productive infection, latency, and on reactivation

2014 ◽  
Vol 112 (1) ◽  
pp. E49-E55 ◽  
Author(s):  
Te Du ◽  
Zhiyuan Han ◽  
Guoying Zhou ◽  
Bernard Roizman
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cultured Cells ◽  
Viral Gene Expression ◽  
The Body ◽  
Productive Infection ◽  
Viral Gene ◽  
Infected Cells ◽  
Simplex Virus ◽  
Portal Of Entry

The key events in herpes simplex virus (HSV) infections are (i) replication at a portal of entry into the body modeled by infection of cultured cells; (ii) establishment of a latent state characterized by a sole latency-associated transcript and microRNAs (miRNAs) modeled in murine peripheral ganglia 30 d after inoculation; and (iii) reactivation from the latent state modeled by excision and incubation of ganglia in medium containing anti-NGF antibody for a timespan of a single viral replicative cycle. In this report, we examine the pattern of synthesis and accumulation of 18 HSV-1 miRNAs in the three models. We report the following: (i) H2-3P, H3-3P, H4-3P, H5-3P, H6-3P, and H7-5P accumulated in ganglia harboring latent virus. All but H4-3P were readily detected in productively infected cells, and most likely they originate from three transcriptional units. (ii) H8-5P, H15, H17, H18, H26, and H27 accumulated during reactivation. Of this group, only H26 and H27 could be detected in productively infected cells. (iii) Of the 18 we have examined, only 10 miRNAs were found to accumulate above background levels in productively infected cells. The disparity in the accumulation of miRNAs in cell culture and during reactivation may reflect differences in the patterns of regulation of viral gene expression during productive infection and during reactivation from the latent state.

scholarly journals Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview

Viruses ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 473 ◽  
Author(s):  
Giuseppe Annunziata ◽  
Maria Maisto ◽  
Connie Schisano ◽  
Roberto Ciampaglia ◽  
Viviana Narciso ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Bioactive Compounds ◽  
Antiviral Agents ◽  
Mechanisms Of Action ◽  
The Body ◽  
Human Virus ◽  
Simplex Virus ◽  
Different Parts ◽  
Hsv Infections

The herpes simplex virus (HSV) is a common human virus affecting many people worldwide. HSV infections manifest with lesions that occur in different parts of the body, including oral, ocular, nasal, and genital skin and mucosa. In rare cases, HSV infections can be serious and lethal. Several anti-HSV drugs have been developed, but the existence of mutant viruses resistant to these drugs led to the individuation of novel antiviral agents. Plant-derived bioactive compounds, and more specifically polyphenols, have been demonstrated to exert marked anti-HSV activity and, among these, resveratrol (RSV) would be considered a good candidate. The purpose of this manuscript is to review the available literature elucidating the efficacy of RSV against HSV and the main demonstrated mechanisms of action.

Herpesvirus Infections

2018 ◽  
Author(s):  
Martin S. Hirsch
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Ganglion Cells ◽  
Human Herpesvirus ◽  
Herpes Infection ◽  
Varicella Zoster ◽  
Clinical Syndromes ◽  
Simplex Virus ◽  
Human Herpesviruses

The herpes group of viruses is composed of at least eight human viruses and numerous animal viruses. The human herpesviruses include herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus types 6 (HHV-6), 7 (HHV-7), and 8 (HHV-8, also known as Kaposi sarcoma–associated herpesvirus). Human herpesviruses share the properties of latency and reactivation. Members of the group can cause productive lytic infections, in which infectious virus is produced and cells are killed, or nonproductive lytic infections, in which viral DNA persists but complete replication does not occur and cells survive. After acute lytic infections, herpesviruses often persist in a latent form for years; periodic reactivations are followed by recurrent lytic infections. Sites of latency vary: HSV and VZV persist in neural ganglion cells, EBV persists in B cells, and CMV probably remains latent in many cell types. The sites of latency for HHV-6 and HHV-7 have not been identified, although both herpesviruses have been detected in salivary glands. All human herpesviruses have a worldwide distribution. Considerable efforts are being directed toward the development of vaccines and antiviral agents that will be active against herpesviruses. This chapter discusses the epidemiology, pathogenesis, diagnosis, prevention, and treatment of herpes simplex virus and varicella-zoster virus and their clinical syndromes. The descriptions of the clinical syndromes include complications and clinical features, as well as descriptions of symptoms. Tables provide information on chemotherapy for primary genital and mucocutaneous herpes infection, suppression of severe and recurring genital herpes infection, and varicella-zoster infection. Figures provide photographic illustrations of the various clinical syndromes. A sidebar about herpesvirus information on the Internet provides further detail. This review contains 123 references, 4 tables, and 6 highly rendered figures.

Herpesvirus Infections

2014 ◽  
Author(s):  
Martin S. Hirsch
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Ganglion Cells ◽  
Human Herpesvirus ◽  
Herpes Infection ◽  
Varicella Zoster ◽  
Clinical Syndromes ◽  
Simplex Virus ◽  
Human Herpesviruses

The herpes group of viruses is composed of at least eight human viruses and numerous animal viruses. The human herpesviruses include herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus types 6 (HHV-6), 7 (HHV-7), and 8 (HHV-8, also known as Kaposi sarcoma–associated herpesvirus). Human herpesviruses share the properties of latency and reactivation. Members of the group can cause productive lytic infections, in which infectious virus is produced and cells are killed, or nonproductive lytic infections, in which viral DNA persists but complete replication does not occur and cells survive. After acute lytic infections, herpesviruses often persist in a latent form for years; periodic reactivations are followed by recurrent lytic infections. Sites of latency vary: HSV and VZV persist in neural ganglion cells, EBV persists in B cells, and CMV probably remains latent in many cell types. The sites of latency for HHV-6 and HHV-7 have not been identified, although both herpesviruses have been detected in salivary glands. All human herpesviruses have a worldwide distribution. Considerable efforts are being directed toward the development of vaccines and antiviral agents that will be active against herpesviruses. This chapter discusses the epidemiology, pathogenesis, diagnosis, prevention, and treatment of herpes simplex virus and varicella-zoster virus and their clinical syndromes. The descriptions of the clinical syndromes include complications and clinical features, as well as descriptions of symptoms. Tables provide information on chemotherapy for primary genital and mucocutaneous herpes infection, suppression of severe and recurring genital herpes infection, and varicella-zoster infection. Figures provide photographic illustrations of the various clinical syndromes. A sidebar about herpesvirus information on the Internet provides further detail. This review contains 123 references, 4 tables, and 6 highly rendered figures.

scholarly journals [18F]FHPG Positron Emission Tomography for Detection of Herpes Simplex Virus (HSV) in Experimental HSV Encephalitis

2005 ◽  
Vol 79 (12) ◽  
pp. 7721-7727 ◽  
Author(s):  
A. R. Buursma ◽  
E. F. J. de Vries ◽  
J. Garssen ◽  
D. Kegler ◽  
A. van Waarde ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Infected Group ◽  
Emission Tomography ◽  
Saline Control ◽  
Control Group ◽  
Positron Emission ◽  
Simplex Virus ◽  
Hsv 1

ABSTRACT Herpes simplex virus type 1 (HSV-1) is one of the most common causes of sporadic encephalitis. The initial clinical course of HSV encephalitis (HSE) is highly variable, and the infection may be rapidly fatal. For effective treatment with antiviral medication, an early diagnosis of HSE is crucial. Subtle brain infections with HSV may be causally related to neuropsychiatric disorders such as Alzheimer's dementia. We investigated the feasibility of a noninvasive positron emission tomography (PET) imaging technique using [18F]FHPG as a tracer for the detection of HSE. For this purpose, rats received HSV-1 (infected group) or phosphate-buffered saline (control group) by intranasal application, and dynamic PET scans were acquired. In addition, the distribution of tracer accumulation in specific brain areas was studied with phosphor storage imaging. The PET images revealed that the overall brain uptake of [18F]FHPG was significantly higher for the infected group than for control animals. Phosphor storage images showed an enhanced accumulation of [18F]FHPG in regions known to be affected after intranasal infection with HSV. High-performance liquid chromatography metabolite analysis showed phosphorylated metabolites of [18F]FHPG in infected brains, proving that the increased [18F]FHPG uptake in infected brains was due to HSV thymidine kinase-mediated trapping. Freeze lesion experiments showed that damage to the blood-brain barrier could in principle induce elevated [18F]FHPG uptake, but this nonspecific tracer uptake could easily be discriminated from HSE-derived uptake by differences in the tracer kinetics. Our results show that [18F]FHPG PET is a promising tool for the detection of HSV encephalitis.

scholarly journals ДЕЯКІ ПОКАЗНИКИ ГУМОРАЛЬНОГО ІМУНІТЕТУ ТА СТАН МІКРОБІОЦЕНОЗУ РЕПРОДУКТИВНИХ ШЛЯХІВ ЖІНОК-ВНУТРІШНЬО ПЕРЕМІЩЕНИХ ОСІБ ІЗ ЗАГРОЗОЮ ПЕРЕРИВАННЯ ВАГІТНОСТІ

2021 ◽  
pp. 56-63
Author(s):  
A. V. Boychuk ◽  
I. Yu. Romanenko
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr ◽  
Simplex Virus ◽  
Ig G

Мета дослідження – вивчити стан мікробіоценозу репродуктивних шляхів та показники гуморального імунітету жінок-внутрішньо переміщених осіб (ВПО) із загрозою переривання вагітності (ЗПВ) для вдосконалення лікувально-профілактичних заходів та профілактики акушерських і перинатальних ускладнень. Матеріали та методи. Обстежено 51 вагітну в I і II триместрах, які перебували на стаціонарному лікуванні з приводу ЗПВ у лікарнях Луганської області й мали статус ВПО (група I). Контрольну групу (група II) склали 64 вагітних із необтяженим анамнезом та фізіологічним перебігом вагітності аналогічного гестаційного терміну й місця проживання. Проведено комплексне клініко-лабораторне обстеження, бактеріоскопічне обстеження вмісту піхви і цервікального каналу, визначення імуноглобулінів класу Ig G до Herpes simplex virus I–II типів (HSV), Cytomegalovirus (CMV) та Epstein–Barr virus (EBV). Результати дослідження та їх обговорення. Кількість випадків неспецифічного вагініту і бактеріального вагінозу вірогідно частіше (р<0,05) реєстрували у жінок групи I (23,53 і 9,38 % та 19,61 і 6,25 % відповідно), нормоценоз достовірно частіше (р<0,05) виявлено в групі II (82,81 і 52,94 % відповідно). Анти-Ig G HSV виявлено у 90,32 % жінок групи I та у 95,24 % –  групи II, анти-IgG CMV – в 80,65 і 85,71 %, анти-IgG до капсидного антигену EBV VCA – в 74,19 і 71,43 % випадків відповідно, антитіла до ранніх антигенів EBV (анти-IgG EBV ЕА) у всіх вагітних були відсутні. Поєднання анти-IgG HSV + анти-IgG CMV відмічено в 70,97 і 71,43 %, серопозитивність анти-IgG HSV + анти-IgG CMV + анти-IgG EBV VCA – в 48,39 і 52,38 % випадках відповідно. Висновки. Розповсюдженість порушень мікробіоценозу серед вагітних-ВПО із ЗПВ у I та II триместрі становить 47,06 %. Антенатальна оцінка серологічного статусу та стану вагінального біоценозу на початку вагітності незалежно від клінічної симптоматики дозволить індивідуалізувати підхід до ведення і своєчасно розробити в разі потреби коригувальні заходи, які будуть сприяти благополучному завершенню вагітності і впливати на здоровʼя матері та її потомства.

scholarly journals Bimodal Temporal Distribution of Herpes Explains Resistant Cases to Oral Antiviral Agents

2019 ◽  
Vol 13 (1) ◽  
pp. 1-2
Author(s):  
K.L. Gaishauser ◽  
C.G. Burkhart
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Antiviral Agents ◽  
Temporal Distribution ◽  
Viral Reactivation ◽  
Mucous Membranes ◽  
Simplex Virus ◽  
Secondary Mode

Herpes Simplex Virus (HSV) is a double-stranded virus that affects the skin and mucous membranes. There has been a long-standing dogma stating that the virus remains dormant and is reactivated from the dorsal root ganglia. However, more recent studies have established that there is a secondary mode of viral reactivation from the epidermis itself. These two distinct reactivation patterns help explain why prophylactic antivirals do not consistently prevent herpes outbreaks.

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