Considerations for Potential Global Expansion of Serum Institute of India

In a time of global vaccine shortages, especially for COVID-19 products, Serum Institute of India (SII) is straining to meet demand for vaccines in India. While this organization is not known worldwide, they entered into a recent alliance with AstraZeneca, who is partnered with Oxford University for Covid-19 vaccine, to manufacture their supply of vaccines for distribution in India. Several other such partnerships are also underway. And, SII is considering plans to become a much larger player, not only in India, but globally. This commentary is focused on if, when, where, why, and how global expansion could proceed. Our work was carried out as a class project to identify options and strategies appropriate for expansion and has been expanded subsequently as events continued to develop.

Dynamics and Trends in Vaccine Procurement and Distribution in Zimbabwe

The subject of COVID-19 vaccines has generated debate across the globe as it has created a fecund ground for a plethora of dynamics such as vaccine diplomacy, misinformation, and struggle for dominance among global powers to mention but a few. Thus, the vaccine subject has taken-center stage in global discourses, resulting in developing and developed nations experiencing challenges in respect to purchase, transparency, and accountability in the administration of vaccines. The subject of vaccines in Zimbabwe has provoked public skepticism indicative of the existing trust deficit between government and the citizens. This emanates from strong evidence of abuse of public resources and hence questions of transparency and accountability especially in relation to disaster situations. To this end, this paper seeks to bring to light the trends and dynamics in vaccine procurement and distribution in Zimbabwe. The study examines the correlation between vaccine diplomacy (donation-trap diplomacy) and vaccine purchases. A chronological analysis of the approved vaccines, rejection of Johnson and Johnson and sudden acceptance, natural resource implications of the donations from ALROSA, poor public resource management, vaccine shortages, vaccine misinformation and vaccine cheating. Possible ways of enhancing vaccine intake through quality information are also discussed and Zimbabwe`s performance against other African nations is examined. The research ends by proposing a series of questions which should be embraced to fully comprehend the trends and dynamics of vaccine procurement and distribution.

Previous COVID-19 Infection and Antibody Levels After Vaccination

Background: The emergence of new COVID-19 variants of concern coupled with a global inequity in vaccine access and distribution has prompted many public health authorities to circumvent the vaccine shortages by altering vaccination protocols and prioritizing persons at high risk. Individuals with previous COVID-19 infection may not have been prioritized due to existing humoral immunity.Objective: We aimed to study the association between previous COVID-19 infection and antibody levels after COVID-19 vaccination.Methods: A serological analysis to measure SARS-CoV-2 immunoglobulin (Ig)G, IgA, and neutralizing antibodies was performed on individuals who received one or two doses of either BNT162b2 or ChAdOx1 vaccines in Kuwait. A Student t-test was performed and followed by generalized linear regression models adjusted for individual characteristics and comorbidities were fitted to compare the average levels of IgG and neutralizing antibodies between vaccinated individuals with and without previous COVID-19 infection.Results: A total of 1,025 individuals were recruited. The mean levels of IgG, IgA, and neutralizing antibodies were higher in vaccinated subjects with previous COVID-19 infections than in those without previous infection. Regression analysis showed a steeper slope of decline for IgG and neutralizing antibodies in vaccinated individuals without previous COVID-19 infection compared to those with previous COVID-19 infection.Conclusion: Previous COVID-19 infection appeared to elicit robust and sustained levels of SARS-CoV-2 antibodies in vaccinated individuals. Given the inconsistent supply of COVID-19 vaccines in many countries due to inequities in global distribution, our results suggest that even greater efforts should be made to vaccinate more people, especially individuals without previous COVID-19 infection.

Immunogenicity of heterologous prime/boost inactivated and mRNA COVID-19 vaccine

Introduction: In August 2021, Thailand imported the BNT162b2 mRNA COVID-19 vaccine. The prioritised group to receive the BNT162b2 vaccine were health professionals. The BNT162b2 vaccine scheduled for healthcare workers were two-dose regimen administered three weeks apart, the third dose booster in two-dose inactivated CoronaVac vaccine recipients or as a second dose in health professionals who had received the CoronaVac or adenoviral-vectored (ChAdOx1-S) vaccine as the first dose regardless of the interval between the first and second dose. Methods: This study aims to evaluate the immunogenicity of the heterologous prime boost CoronaVac followed by BNT162b2 in health professionals. Results: The CoronaVac/BNT162b2 vaccine recipients elicited higher neutralizing activity against the original Wuhan and all variants of concern than in the recipients of the two-dose CoronaVac. Conclusions: The heterologous CoronaVac/BNT162b2 could be used as an alternative regimen in countries experiencing the vaccine shortages and in individuals experiencing the adverse events following CoronaVac.

Examining Factors Influencing COVID-19 Vaccine Tourism for International Tourists

Since early 2020, the COVID-19 pandemic has had a devastating impact on global tourism. Vaccine tourism is a novel health tourism concept, which provides an opportunity for countries with a vaccine surplus to offer medical tourism packages to entice international tourists from countries with vaccine shortages to visit for sightseeing and receive vaccine inoculations. Understanding the factors that influence people to adopt vaccine tourism is one of the strategies that could boost a country’s tourism sector and help to revive the local economy. This study aims to examine the factors influencing the intention to adopt and recommend COVID-19 vaccine tourism among young travelers. A total of 179 questionnaire surveys were collected from traveling-related social media outlets. Partial least squares structural equation modeling (PLS-SEM) was performed to analyze the data. The results indicate that young tourists in Thailand are inclined to promote vaccine tourism to others. Price value appears to be the most significant influencing factor on intentions to both adopt and recommend vaccine tourism. Additionally, trust in the foreign healthcare system was positively associated with young travelers’ intention to recommend vaccine tourism to others. Theoretically, this research adds to the medical tourism literature, suggesting that, while trust is an important factor influencing the medical tourism decision, it appears to be insignificant in the context of vaccine tourism.

Previous COVID-19 infection and antibody levels after vaccination

BackgroundThe emergence of new COVID-19 variants of concern coupled with a global inequity in vaccine access and distribution, prompted many public health authorities to circumvent the vaccine shortages by altering vaccination protocols and prioritizing high-risk individuals. Those with previous COVID-19 infection may have not been prioritized due to existing humoral immunity.ObjectiveWe aim to study the association between previous COVID-19 infection and antibody levels after COVID-19 vaccination.MethodsA serological analysis to measure SARS-CoV-2 IgG, IgA and neutralizing antibodies was performed on individuals who received one or two doses of either BNT162b2 or ChAdOx1 vaccines in Kuwait. Generalized linear regression models adjusted for individual characteristics and comorbidities were fitted to study the average levels of IgG and neutralizing antibodies in vaccinated individuals based who had previous COVID-19 infection compared to those who had not.ResultsA total of 1025 individuals were recruited. The mean levels of IgG, IgA and neutralizing antibodies were higher in vaccinated subjects with previous COVID-19 infection when compared with those vaccinated without previous COVID-19 infection. Regression analysis showed a steeper slope of decline for IgG in vaccinated individuals without previous COVID-19 infection in comparison with vaccinated individuals with previous COVID-19 infection.ConclusionPrevious COVID-19 infection appears to elicit robust and sustained levels of SARS-CoV-2 antibodies in vaccinated individuals. Given the inconsistent supply of COVID-19 vaccines in many countries due to the global inequity, our results point towards wider vaccination plans to especially cover individuals without previous COVID-19 infection.

Physical activities, nutrition, and mental health of people in the community during the outbreak of coronavirus disease 2019: A review study

Background: At the end of December 2019, the spread of a new infectious disease was reported in Wuhan, China, which was officially named coronavirus disease 2019 (COVID-19) by the World Health Organization. The epidemic not only causes high rates of death due to viral infections but also has led to psychological catastrophe worldwide. Uncertainty and unpredictability of this disease have created a high potential for psychological fear of disease transmission. To prevent further outbreaks of COVID-19, it may be necessary to adopt such measures as non-pharmacological interventions, quarantine, and social distancing due to vaccine shortages. However, the implementation of these health policies, despite the positive consequences, has created negative psychological effects on society. Fear of disease, fear of death, spread of false news and rumors, and reduction of social relations threaten the health of people in society. It is not yet clear that how much and to what extent this issue will affect mental health in such long-term social isolation. It is supposed that the post-COVID-19 era will be coincided with the emergence of a large number of individuals with such problems as anxiety, obsession, hypochondriasis, depression, and mental disorders. Therefore, the adoption of appropriate solutions to prevent these consequences would contribute people to be encouraged to move from a loneliness and introversion state to an active and energetic one. Regular physical activity and exercise and proper nutrition can be among the ways to prevent such mental disorders.

Organised crime will gain from world vaccine shortages

Significance However, it is vast global demand for the restricted supply of COVID-19 vaccines that offers the most alluring prize for criminal gangs. Black markets thrive in situations where demand outstrips supply, and there has long been an illicit trade in medicines. Impacts Countries with underdeveloped pharmaceutical supply chains will be vulnerable to theft and diversion of vaccine supplies. Government vaccine strategies could be undermined by high-profile black market vaccine scandals that damage public trust. Pharmaceutical companies are vulnerable to reputational damage if their supply chains are found to be tampered with. Criminal profits will fund other illegal activities such as trafficking of people, drugs and arms.