Systemic toxicity in a child after topical cyclopentolate eye drops application

An 8-year-old girl was seen in our ophthalmology OPD who had come with complaints of mild pain in both eyes for 1 month. Her unaided vision in both eyes was 6/6. Her weight was 20 kg. Cyclopentolate 1% eye drops was administered twice to the child at 5 min interval in both eyes. The child became restless after 30 min of installation of eye drops installation. She started behaving abnormally and was not allowing to do retinoscopic examination. She had altered behavior, visual hallucination, and difficulty in walking. She was disoriented with slurred speech. She had ataxia and frequent tightening of limbs with jerky movements and was plucking her hair. Her pulse rate was 90/min and blood pressure was 120/90 mm of Hg. Her oxygen saturation was 94% in room air. The child was shifted to nearby hospital where a paediatrician and anesthesiologist were available and was kept under observation. Child’s pulse, blood pressure, and oxygen saturation were monitored for the next 5 hours. The child recovered completely over the next 8 hours.

Visual hallucination caused by multiloculated hydrocephalus in the frontal lobe: a case report

A 72-year-old man consulted our hospital for visual hallucination. His non-contrast computed tomography (CT) of head showed multiloculated hydrocephalus in the frontal lobe. Memantine treatment was started and his visual hallucination disappeared. This is a rare case of frontal lobe damage causing visual hallucination.

Intracerebral Hemorrhage, Visual Hallucination and COVID-19: What Is the Connection? A Case-Related Review of the Literature on Peduncular Hallucinosis Following Intracerebral Hemorrhage

Previous publications have discussed the occurrence of intracerebral hemorrhages, hallucinations and psychosis in COVID-19 patients. In this article, we have reviewed the literature on the subject while depicting the case of a 63-year-old female patient who suffered from an intracerebral hemorrhage in the right basal ganglia and thalamus two weeks after a COVID-19 diagnosis and who developed a visual hallucinosis shortly after. We concluded that, while there may be a correlation between COVID-19 and hallucinations according to current literature, more research is yet needed to clarify. In our case, we rather interpreted the hallucinations in the context of a peduncular hallucinosis related to the intracerebral hemorrhage. We compared our patient’s lesion localization to other 15 reported cases of peduncular hallucinations following intracerebral hemorrhages reported on Pubmed. In summary, the lesions were localized in the pons in 52.9% of the cases, 17.7% were in the thalamus and/or the basal ganglia, 17.7% in the mesencephalon and respectively 5.8% in the temporal and occipital lobe. The distribution pattern we found is consistent with the previously proposed mechanism behind peduncular hallucinations.

No specific relationship between hypnotic suggestibility and the rubber hand illusion: a commentary with new and verification analyses

In a recent study, Lush et al. (Nat Commun 11, 4853, 2020) claimed that they found “substantial relationships” between hypnotizability and experimental measures of the rubber hand illusion. The authors proposed that hypnotizable participants control their phenomenology to meet task expectations arising from the experimental paradigm. They further suggest that the rubber hand illusion “may or may not” be entirely explained by hypnotic suggestions driven by task expectancies and therefore could reflect top-down control of perception, instead of multisensory mechanisms. However, in reanalyzing their data, we observe no significant relationships between hypnotic suggestibility and the rubber hand illusion when quantified using a control condition in line with the authors’ preregistered hypothesis. Furthermore, we note that the relationships that the authors describe are weak and observed for a visual “hallucination” control experience and in the control condition, indicating a general influence of hypnotizability on cognition, rather than sensations that specifically relate to the rubber hand illusion. Overall, the results fit well with the view that the rubber hand illusion is a perceptual illusion driven primarily by multisensory mechanisms.