Hydroxyl-containing bis(sulfonates). Reaction of 1,4-dibromo-2,3-butanedione with water, methanol and sodium sulfite

Sulfonates are well-known substances with a variety of applications, e.g. as surfactants. On the other hand, bis(sulfonates) bearing hydroxyl or keto group(s) in between the sulfonate groups can be used with or without further modification as starting materials for the preparation of new type of molecules capable to form either complexes or in general supramolecular structures. The synthesis of three hydroxyl-bearing bis(sulfonates), 2-hydroxypropane-1,3-bis(sodium sulfonate) 4, DL-2,3-dihydroxybutane-1,4-bis(sodium sulfonate) 8, and sodium 2,3,4-trihydroxy-1-sulfonate 7 (as by-product) via the Strecker sulfonation are described. Interestingly, under similar conditions, sulfonation of 1,4-dibromo-2,3-butanedione 9 was found to be very complicated and no pure product could be isolated, despite previously reported results on sulfonation of α-halogenated ketones in high yields. There are indications that SO3 2 - attacks at the carbonyl carbon of 9 followed by rearrangement and expulsion of SO4 2 - . 1,4-dibromo-2,3-butanedione 9, bearing two keto groups next to methylene groups, can potentially exist as enols or in the case of its solution in hydroxylic solvents in the form of hemiketals or geminal diols. This behavior of 9 when is dissolved in CDCl3, CD3OD and D2O was studied by means of UV-Vis, 1H and 13C NMR and the nature of the adducts formed was elucidated.

Effect of carbazochrome sodium sulfonate combined with tranexamic acid on blood loss and inflammatory response in patients undergoing total hip arthroplasty

Aims The purpose of this study was to examine the efficacy and safety of carbazochrome sodium sulfonate (CSS) combined with tranexamic acid (TXA) on blood loss and inflammatory responses after primary total hip arthroplasty (THA), and to investigate the influence of different administration methods of CSS on perioperative blood loss during THA. Methods This study is a randomized controlled trial involving 200 patients undergoing primary unilateral THA. A total of 200 patients treated with intravenous TXA were randomly assigned to group A (combined intravenous and topical CSS), group B (topical CSS), group C (intravenous CSS), or group D (placebo). Results Mean total blood loss (TBL) in groups A (605.0 ml (SD 235.9)), B (790.9 ml (SD 280.7)), and C (844.8 ml (SD 248.1)) were lower than in group D (1,064.9 ml (SD 318.3), p < 0.001). We also found that compared with group D, biomarker level of inflammation, transfusion rate, pain score, and hip range of motion at discharge in groups A, B, and C were significantly improved. There were no differences among the four groups in terms of intraoperative blood loss (IBL), intramuscular venous thrombosis (IMVT), and length of hospital stay (LOS). Conclusion The combined application of CSS and TXA is more effective than TXA alone in reducing perioperative blood loss and transfusion rates, inflammatory response, and postoperative hip pain, results in better early hip flexion following THA, and did not increase the associated venous thromboembolism (VTE) events. Intravenous combined with topical injection of CSS was superior to intravenous or topical injection of CSS alone in reducing perioperative blood loss. Cite this article: Bone Joint Res 2021;10(6):354–362.

The Impact of AN Contribution on the Thermal Characteristics and Molecular Dynamics of Novel Acrylonitrile–Styrene–Styrene Sodium Sulfonate Terpolymers

We performed a free radical solution polymerization of new acrylonitrile (AN), styrene (St) and styrene sodium sulfonate (SSS) acceptor–donor acceptor monomer systems. The compositions and structures of the produced terpolymers were elucidated using CHNS elemental analysis, and Fourier transform infrared (FTIR) spectroscopies. Three terpolymers candidates were chosen for detailed thermal investigations, where the AN molar ratio varied almost threefold (from ~6.9% to ~17.4%) while the molar ratios of St and SSS varied slightly, at average values around 76.0% and 12.9%, respectively. The glass transition (Tg) values of the terpolymers were measured calorimetrically. In addition, thermal gravimetric analyses (TGA) of the samples were conducted in the temperature range from room temperature to 800 °C. All terpolymers exhibited a single Tg value, indicating random copolymerization of the monomeric species. TGA results revealed that variation of the AN molar ratio had a significant influence on the thermal stabilities of the terpolymers. The impact of AN contribution on the molecular dynamics of the glass transition in the terpolymers was explained quantitatively in a framework of a molecular model.

Comparison of Flow and Solubility Properties of Mineral Trioxide Aggregate Cement with Two Additive Plasticizing Agents: An In Vitro Study

Proposition: To evaluate the physical properties of flow and solubility of pure and improved mineral trioxide aggregate (MTA) cement with the addition of two plasticizing agents: sodium ether polycarboxylate and sodium naphthalene sulfonate at three different concentrations. Material and Methods: Flow and solubility tests were carried out using the established methodology recommended by the 57 ANSI/ADA and ISO 6876:2012 standards. Pure MTA was used as control group and was compared to the MTA containing sodium ether polycarboxylate and sodium naphthalene sulfonate at concentrations of 0.5%, 1.0% and 1.5%. Data were analyzed by one-way analysis of variance followed by a post-hoc Tukey test at a 5% significance level. Results: Sodium ether polycarboxylate increased the MTA flow at the three concentrations. The flow increased with increasing concentration (P<0.05). Sodium sulfonate naphthalene also facilitated flow, though it was inferior to sodium ether polycarboxylate. Sodium naphthalene sulfonate promoted a significant increase in the solubility of MTA (p=0.000). Conclusions: The additives improved the physical properties of MTA. Sodium ether polycarboxylate was found to be superior to sodium naphthalene sulfonate at all concentrations.