After concisely highlighting the book’s main themes, this chapter explains why it is important to think about responses to radical skepticism, and provides an overview of the book and its key concepts. First, it identifies three reasons it is worthwhile to devote time to thinking about how best to respond to radical skepticism. These reasons are that it enables us to consider (in a more informed way) our options for dealing with less radical forms of skepticism (e.g. moral or religious skepticism), it affects our stance on a multitude of other positions in epistemology and other subfields in philosophy, and it is intrinsically interesting. Second, this chapter provides a detailed overview of the book’s contents, noting that Part I objects to argument-based resistance to radical skepticism, Part II defends noninferential commonsense epistemic-intuition-based resistance to radical skepticism, and Part III responds to objections to epistemic intuition (on which the approach to skepticism, developed in Part II, heavily relies). Third, it clarifies three key concepts that play an important role in the book—skepticism, justification, and evidence—by distinguishing a variety of understandings of each concept and highlighting the ones that are relevant to the book’s content.