From Neuroethics to Neo-romanticism. Aldous Huxley in Response to Current Proposals for Ethical and Legal Regulation of Neuroscience

The neuroethics field emerged in the early 2000s in an effort to face important philosophical dilemmas and anticipate disruptive social changes linked to the use of neurotechnology (Safire, 2002). From very early on, this field grew out of two core issues, namely inquiries into the ethics of neuroscience –concerning the moral use of knowledge and technology– and inquiries into the neuroscience of ethics –on how new brain function evidence can change human self-understanding (Roskies 2002). Similarly, neurolaw is now on a parallel path with two main pillars as Chandler (2018) suggested, (1) “self-reflexive inquiry” (the neuroscience of law) and (2) “inquiry into the development and use of brain science and technologies” (the law of neuroscience). In this paper, I suggest that these two lines of research are still excessively disconnected from one another and, to support this claim, I analyze the three potential point-of-no-return risks that Aldous Huxley associated with technological challenges, namely centralization of power, bureaucratic alienation, and scientific idealism. In addition, I show how Huxley shifted analysis of technological problems from a focus on the rights of potential victims to the duties of potential aggressors. Finally, I argue that Aldous Huxley’s view on how to build a bridge that brings pillars 1) and 2) closer together also helps prevent the technological point-of-no-return. According to Huxley, the key is found in paying particular attention to understanding contemplative activity, reinforcing its role in the study of reality, and, eventually, returning the romantic gaze updated to academia.

Rigenerazione urbana e produzione di qualità paesaggistica: connessioni possibili fra strategie e strumenti

Urban regeneration and landscape policies have usually been developed on a parallel path. The change of paradigm marked by the ELC in the conception of landscape, that now includes ordinary and degraded landscapes as central to human well-being, implies that the strategies of urban regeneration and those of improving landscape quality can be complementary. Starting with some remarks on the ambiguities of the concept of urban regeneration and the threats it poses to landscape quality, the article focuses on the opportunities offered by landscape planning for inclusive and self-sustaining urban regeneration. The paper refers to practices tested in the Puglia region to point out the role played by the political tools to this end.

Noisy Multipath Parallel Hybrid Model for Remaining Useful Life Estimation (NMPM)

The parallel hybrid models of different deep neural networks architectures are the most promising approaches for remaining useful life (RUL) estimation. In light of that, this paper introduces for the first time in the literature a new parallel hybrid deep neural network (DNN) solution for RUL estimation, named as the Noisy Multipath Parallel Hybrid Model for Remaining Useful Life Estimation (NMPM). The proposed framework comprises of three parallel paths, the first one utilizes a noisy Bidirectional Long-short term memory (BLSTM) that used for extracting temporal features and learning the dependencies of sequence data in two directions, forward and backward, which can benefit completely from the input data. While the second parallel path employs noisy multilayer perceptron (MLP) that consists of three layers to extract different class of features. The third parallel path utilizes noisy convolutional neural networks (CNN) to extract another class of features. The concatenated output of the previous parallel paths is then fed into a noisy fusion center (NFC) to predict the RLU. The NMPM has been trained based on a noisy training to enhance the generalization behavior, as well as strengthen the model accuracy and robustness. The NMPM framework is tested and evaluated by using CMAPSS dataset provided by NASA.

A Parallel Ratchet-Stroke Mechanism Leads to an Optimum Force for Molecular Motor Function

ABSTRACTMolecular motors convert chemical potential energy into mechanical work and perform a great number of critical biological functions. Examples include the polymerization and manipulation of nucleic acids, the generation of cellular motility and contractility, the formation and maintenance of cell shape, and the transport of materials within cells. The mechanisms underlying these molecular machines are routinely divided into two categories: Brownian ratchet and power stroke. While a ratchet uses chemical energy to bias thermally activated motion, a stroke depends on a direct coupling between chemical events and motion. However, the multi-dimensional nature of protein energy landscapes allows for the possibility of multiple reaction paths connecting two states. Here, we investigate the properties of a hypothetical molecular motor able to utilize parallel ratchet and stroke translocation mechanisms. We explore motor velocity and force-dependence as a function of the energy landscape of each path and reveal the potential for such a mechanism to result in an optimum force for motor function. We explore how the presence of this optimum depends on the rates of the individual paths and show that the distribution of stepping times characterized by the randomness parameter may be used to test for parallel path mechanisms. Lastly, we caution that experimental data consisting solely of measurements of velocity as a function of ATP concentration and force cannot be used to eliminate the possibility of such a parallel path mechanism.SIGNIFICANCEMolecular motors perform various mechanical functions in cells allowing them to move, replicate and perform various housekeeping functions required for life. Biophysical studies often aim to determine the molecular mechanism by which these motors convert chemical energy to mechanical work by fitting experimental data with kinetic models that fall into one of two classes: Brownian ratchets or power strokes. However, nothing a priori requires that a motor function via a single mechanism. Here, we consider a theoretical construct where a motor has access to both class of mechanism in parallel. Combining stochastic simulations and analytical solutions we describe unique signatures of such a mechanism that could be observed experimentally. We also show that absence of these signatures does not formally eliminate the existence of such a parallel mechanism. These findings expand our theoretical understanding of the potential motor behaviors with which to interpret experimental results.

Conclusion

This chapter summarizes the book’s central claims and looks at paths for future work on the applied ethics of artistic creation and ethical criticism. It suggests the need for two parallel strands of inquiry: On the one hand, as the term “applied ethics” suggests, there is a need for a finer-grained understanding of both the artistic and ethical contexts of artistic creation—an understanding that will need to be informed by research across a number of fields, including anthropology, art history, and moral psychology. On the other hand, whatever details of that context are revealed by this fine-grained analysis, there will be a more abstract conceptual challenge about how to reconcile the norms of that art-historical and ethical context with those in currency in the art-historical and ethical context from which one is judging the work. So, the parallel path of inquiry is in metaethics.

Taking a Parallel Path

This chapter discusses how Leo Wharton got into the film industry. Leo's earliest documented stage appearance was in 1893, in the play The Fairies' Well. After a few years of itinerant acting, Leo was able to secure steadier employment at the Hopkins Grand Opera in Saint Louis, where his brother Ted was already performing. As part of Colonel Hopkins's theatrical company, Leo assumed various stage roles in the popular daylong “continuous performance” programs that Hopkins pioneered, which combined live drama and between-the-acts vaudeville. Leo's first known (and first credited) film appearance was in the title role of Lincoln in Abraham Lincoln's Clemency (1910), a photoplay produced by Ted Wharton for Pathé. The role not only garnered good reviews for his sympathetic performance and even for his resemblance to the revered figure whom he was portraying; it also led to an offer as a director for Pathé, the studio for which Ted was then working. There, Leo began directing similar shorts, such as the period historical drama The Rival Brothers' Patriotism (1911). Since early movie audiences seemed especially fond of marital comedies, Leo produced several shorts in 1913 that revolved around wedding-day complications. While these and other short pictures that Leo produced for Pathé were often predictable in their plotting and formulaic in their execution, they were nonetheless popular with audiences and profitable for Pathé. Moreover, they established his reputation in the industry.