Application of the optoacoustic effect to measure glucose concentration

Currently, there are only two invasive methods available for measuring blood glucose: the first, the most common method, requires blood to be drawn, which is then transported and analyzed to a clinical laboratory, applying the blood to a glucometer test strip. Sampling blood, especially in children, is a rather complicated process, in addition, the results of clinical trials take time. Therefore, non-invasive, continuous monitoring of glucose by optoacoustic method is quite promising. We used an optoacoustic method with a high spatial resolution, which makes it possible to measure the concentration of glucose in the blood. Experimental measurements were carried out in porcine blood at various glucose concentrations

Biomedical Photoacoustic Imaging and Sensing Using Affordable Resources

The photoacoustic (PA) effect, also called the optoacoustic effect, was discovered in the 1880s by Alexander Graham Bell and has been utilized for biomedical imaging and sensing applications since the early 1990s [...]

THE VISUAL MANIFESTATION OF THE OPTOACOUSTIC EFFECT IN FILMS ON WATER

Recently, in the laboratory experiments we have presented effect of sound generation in air seems like «crackling» when a film on the water surface was irradiated by IR- laser radiation with a wavelength of 10.5 μm. For clean water surface, no crackling was detected. It means, that film presence significantly changed the conditions for the formation of local heating areas in water and acoustic waves emission. The sound characteristics were preliminarily investigated depending on the water temperature, the film thickness and its substance, as well as the radiation intensity. However, the effect insufficient repeatability in some experiments stimulated additional studies of the observed optoacoustic effect in order to obtain visual information about the processes occurring in the irradiated area using video recording. This study results are presented in this paper on the example of a laboratory and field experiments.

Experimental studies of optoacoustic effect on the model of erythrocytes in the presence of carbon nanoparticles

Experimental model has been developed to study optoacoustic signal from model blood cells presented by polystyrene microspheres with nanoparticles. It was found out that nanoparticles due to their strong absorption of light significantly affect the coefficient of cellular optical absorption, while the thermophysical parameters, namely the coefficient of thermal expansion, compressibility and isobaric specific heat of cells remain unchanged, since nanoparticles occupy a small intracellular volume compared to the cell volume. Optoacoustic signals were obtained using model solutions at various concentrations of cells and nanoparticles using 1064 nm laser. The results of experimental measurements using LIMO 100–532/1064-U system based on Nd:YAG showed that the amplitude of the optoacoustic signal increased without increasing the temperature in the laser area.