Deleuze’s philosophy is an empiricism because like Epicurus and Locke he begins with sensibility as a response to shock from outside, and because like James and Dewey, relations are empirical and discovered by affect. Deleuze proposes to establish empiricism “transcendentally,” that is, immanently, without introducing anything beyond experience and what can be deduced of its empirical genesis. Transcendental empiricism is a more consistently empirical empiricism. It is also James’s radical empiricism reinterpreted through the eyes of a uniquely acute student of European philosophy. He presents an alternative to classical ideas of identity and difference. Reversing Plato, difference is original, positive, and aboriginally multiple, a virtual pre-individuality from which empirical distinctions emerge. Overcoming original identity is a boon to a more consistent empiricism because all experience arises from relational features of milieus, where the tenor of experience is difference and relation, not the same and self-identical.