scholarly journals Development and Characterization of Nanoemulsion-based Buccal Films of Atorvastatin Calcium for Enhancement of Hypolipidemic Effect

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Moetaza Soliman ◽  
Fatma Bakr ◽  
Hassan Elsabbagh
Keyword(s):  
Hypolipidemic Effect ◽  
Atorvastatin Calcium ◽  
Buccal Films

scholarly journals Isolation, Identification and Characterization of Degradation Impurity of Atorvastatin in Fixed Dose Combination of Atorvastatin and Ezetimibe

2019 ◽  
Vol 11 (05) ◽  
Author(s):  
Rajesh Desai ◽  
Suresh Koradia
Keyword(s):  
Reversed Phase ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Forced Degradation ◽  
Preparative Hplc ◽  
Atorvastatin Calcium ◽  
Isolation And Characterization ◽  
Dose Combination ◽  
Liquid Chromatographic

The objective of this study is to isolation and characterization of unknown degradation product of Atorvastatin calcium in combination formulation product with Ezetimibe by using modern techniques of separation and aracterization. An unknown impurity is generating during a forced degradation study of Atorvastatin and Ezetimibe fixed-dose combination tablets. By using the gradient reversed-phase high-pressure liquid chromatographic method, unknown degradation impurity was detected and quantified in the range of 0.05% to 0.2% of Atorvastatin. The impurity was enriched by extreme oxidation degradation of Atorvastatin and isolated through preparative HPLC. The structure of the impurity was characterized by mass and NMR spectrum.

Development and characterization of floating spheroids of atorvastatin calcium loaded NLC for enhancement of oral bioavailability

2015 ◽  
Vol 44 (6) ◽  
pp. 1448-1456 ◽  
Author(s):  
Kritika Sharma ◽  
Supandeep Singh Hallan ◽  
Bharat Lal ◽  
Ankur Bhardwaj ◽  
Neeraj Mishra
Keyword(s):  
Oral Bioavailability ◽  
Atorvastatin Calcium

Physicochemical characterization of atorvastatin calcium/ezetimibe amorphous nano-solid dispersions prepared by electrospraying method

2016 ◽  
Vol 45 (6) ◽  
pp. 1138-1145 ◽  
Author(s):  
Azin Jahangiri ◽  
Mohammad Barzegar-Jalali ◽  
Yousef Javadzadeh ◽  
Hamed Hamishehkar ◽  
Khosro Adibkia
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Atorvastatin Calcium

scholarly journals In vitro and in vivo characterization of domperidone-loaded fast dissolving buccal films

2020 ◽  
Vol 28 (3) ◽  
pp. 266-273 ◽  
Author(s):  
Gamal M. Zayed ◽  
Saleh Abd-El Rasoul ◽  
Mohamed A. Ibrahim ◽  
Mohammed S. Saddik ◽  
Doaa H. Alshora
Keyword(s):  
In Vivo Characterization ◽  
Buccal Films

scholarly journals Characterization of two new degradation products of atorvastatin calcium formed upon treatment with strong acids

2019 ◽  
Vol 15 ◽  
pp. 2085-2091
Author(s):  
Jürgen Krauß ◽  
Monika Klimt ◽  
Markus Luber ◽  
Peter Mayer ◽  
Franz Bracher
Keyword(s):  
Degradation Products ◽  
Crystal Structure Analysis ◽  
Side Chain ◽  
The Novel ◽  
Isopropyl Group ◽  
X Ray ◽  
Atorvastatin Calcium ◽  
Acidic Conditions ◽  
Strong Acids

Atorvastatin calcium (Lipitor®, Sortis®) is a well-established cholesterol synthesis enzyme (CSE) inhibitor commonly used in the therapy of hypercholesterolemia. This drug is known to be sensitive to acid treatment, but only little data has been published on the structures of the degradation products. Here we report the identification of two novel degradation products of atorvastatin, which are formed only under drastic acidic conditions. While treatment with conc. sulfuric acid led to a loss of the carboxanilide residue (accompanied by an expectable lactonization/dehydration process in the side chain), treatment with conc. aqueous hydrochloric acid gave a complex, bridged molecule under C–C-bond formation of the lactone moiety with the pyrrole, migration of the isopropyl group and loss of the carboxanilide residue. The novel degradation products were characterized by NMR spectroscopy, HRMS data and X-ray crystal structure analysis.

Manufacture and characterization of mucoadhesive buccal films

2011 ◽  
Vol 77 (2) ◽  
pp. 187-199 ◽  
Author(s):  
Javier O. Morales ◽  
Jason T. McConville
Keyword(s):  
Buccal Films

scholarly journals Preparation and Characterization of a Novel Cocrystal of Atorvastatin Calcium with Succinic Acid Coformer

2019 ◽  
Vol 19 (3) ◽  
pp. 660
Author(s):  
Yudi Wicaksono ◽  
Dwi Setyawan ◽  
Siswandono Siswandono ◽  
Tri Agus Siswoyo
Keyword(s):  
Succinic Acid ◽  
Dissolution Rate ◽  
Intermolecular Hydrogen Bond ◽  
Acid Amide ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Atorvastatin Calcium ◽  
Hydrogen Bond Interactions

Preparation and characterization of a novel cocrystal of atorvastatin calcium with succinic acid coformer were successfully performed. This research aims to modify the crystalline form of atorvastatin calcium through cocrystallization with succinic acid coformer. The cocrystal was prepared by a solvent evaporation method and characterized by Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The atorvastatin calcium-succinic acid cocrystal has new crystalline peaks at 2θ of 12.9, 18.2 and 26.7° indicating the formation of a new crystalline phase. The cocrystal showed the melting point at 205.7 °C with an enthalpy of fusion 30.2 J/g which is different from the initial components. The FTIR spectra of cocrystal showed the shifting of absorption peaks of groups of initial components indicating of formation of atorvastatin calcium-succinic acid cocrystal through acid–amide intermolecular hydrogen bond interactions. The solubility and dissolution test showed that the cocrystal has solubility and dissolution rate significantly higher than the solubility and dissolution rate of pure atorvastatin calcium.

scholarly journals Characterization of Insulin Mucoadhesive Buccal Films: Spectroscopic Analysis and In Vivo Evaluation

Symmetry ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 88
Author(s):  
Maram Diab ◽  
Al-Sayed Sallam ◽  
Imad Hamdan ◽  
Randa Mansour ◽  
Rohanah Hussain ◽  
...  
Keyword(s):  
Delivery System ◽  
Protective Action ◽  
Enzyme Linked Immunosorbent Assay ◽  
In Vivo Evaluation ◽  
In Vivo Testing ◽  
Glucose Lowering Effect ◽  
Unit Dose ◽  
Buccal Films

Insulin mucoadhesive buccal films (MBF) are a noninvasive insulin delivery system that offers an advantageous alternative route of administration to subcutaneous injection. One major concern in the formulation of insulin MBF is the preservation of an insulin secondary structure in the presence of the other film components. Buccal films were formulated using chitosan, glycerin, and L-arginine. The MBF-forming solutions (MBF-FS) and the films (MBF) were examined for their chemical and structural stability and for their in vivo activity. Enzyme-Linked Immunosorbent Assay (ELISA) of the insulin-loaded MBF showed that each individualized unit dose was at least loaded with 80% of the insulin theoretical dose. Results of Synchrotron Radiation Circular Dichroism (SRCD) measurements revealed that MBF-FS retained the α-helices and β–sheets conformations of insulin. Fourier transform infrared (FTIR)-microspectroscopy (FTIR-MS) examination of insulin MBF revealed the protective action of L-arginine on insulin structure by interacting with chitosan and minimizing the formation of an unordered structure and β-strand. A blood glucose-lowering effect of insulin MBF was observed in comparison with subcutaneous (S.C) injection using a rat model. As a result; chitosan-based MBFs were formulated and characterized using SRCD and FTIR-MS techniques. Furthermore, the results of in vivo testing suggested the MBFs as a promising delivery system for insulin.

Sign in / Sign up

Export Citation Format

Share Document