Suicide is a serious public health problem surrounded by stigma, myths, and taboos. With an annual average of 81,746 suicide deaths in the period 2010–2014 and an age-adjusted suicide rate of 9.3 per 100,000 population (age-unadjusted rate of 9.6), suicide continues to be a public health problem of great relevance in the Region of the Americas. Contrary to common belief, suicides are preventable with timely, evidence-based, and often low-cost interventions. It is estimated that for each suicide that occurs, there are more than 20 attempts. Suicide can occur at any age and it is the third highest cause of death among young people between the ages of 20 and 24 in the Region of the Americas. This report corresponds to the five-year period between 2010 and 2014. It provides a general description of suicide mortality in the Americas, by subregions and countries. It analyzes the distribution of suicide according to age, sex, and methods used, along with the changes in suicide from 2010 to 2014. This report is limited to the study of mortality as, in most countries, no record of self-harm exists, due to lack of appropriate surveillance systems. In the period 2010–2014, 55.8% of suicide deaths in the Region occurred in North America. The age-adjusted suicide rate was also highest in North America (12.8 per 100,000 population), which along with the non-Hispanic Caribbean (9.8) was higher than the regional rate, while the other two subregions had rates lower than the regional rate (6.7 in Central America, the Hispanic Caribbean, and Mexico; 6.9 in South America). In Latin America and the Caribbean, it is essential that national suicide prevention programs be developed, especially in those countries with higher suicide rates. This report identifies 12 countries in the Region of the Americas with high suicide rates compared with the regional average and where two-thirds of the suicide deaths are concentrated. Strengthening information systems and surveillance of suicidal behavior is required. Improving mortality registries alone is not enough. It is also necessary to develop registries of suicidal behavior and implement follow-up mechanisms in high-risk cases. This report identifies the most frequent suicide methods. The availability of firearms is an important risk factor, particularly in North America. Access to pesticides in rural areas is another risk factor, especially in the non-Hispanic