ex vivo tissue
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2021 ◽  
Author(s):  
Yoshiaki Yasuno ◽  
Ibrahim Abd El-Sadek ◽  
Arata Miyazawa ◽  
Larina Tzu-Wei Shen ◽  
Thitiya Seesan ◽  
...  

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2103
Author(s):  
Barbara Gyuricza ◽  
Judit P. Szabó ◽  
Viktória Arató ◽  
Noémi Dénes ◽  
Ágnes Szűcs ◽  
...  

Tumor hypoxia induces angiogenesis, which is required for tumor cell survival. The aminopeptidase N receptor (APN/CD13) is an excellent marker of angiogenesis since it is overexpressed in angiogenic blood vessels and in tumor cells. Asparagine-glycine-arginine (NGR) peptide analogs bind selectively to the APN/CD13 recepto, therefore, they are important vector molecules in the development of a PET radiotracer which is capable of detecting APN-rich tumors. To investigate the effect of glycosylation and pegylation on in-vivo efficacy of an NGR-based radiotracer, two 68Ga-labeled radioglycopeptides were synthesized. A lactosamine derivative was applied to glycosylation of the NGR derivative and PEG4 moiety was used for pegylation. The receptor targeting potential and biodistribution of the radiopeptides were evaluated with in vivo PET imaging studies and ex vivo tissue distribution studies using B16-F10 melanoma tumor-bearing mice. According to these studies, all synthesized radiopeptides were capable of detecting APN expression in B16-F10 melanoma tumor. In addition, lower hepatic uptake, higher tumor-to background (T/M) ratio and prolonged circulation time were observed for the novel [68Ga]-10 radiotracer due to pegylation and glycosylation, resulting in more contrasting PET imaging. These in vivo PET imaging results correlated well with the ex vivo tissue distribution data.


Author(s):  
Mariya S. Kopyeva ◽  
Serafima A. Filatova ◽  
Vladimir A. Kamynin ◽  
Tamara K. Chekhlova ◽  
Vladimir B. Tsvetkov

2021 ◽  
Vol 79 ◽  
pp. S604
Author(s):  
L.A.M.J.G. Van Riel ◽  
R.A.A. Van Kollenburg ◽  
T.M. De Reijke ◽  
C.D. Savci - Heijink ◽  
R. Zweije ◽  
...  

2021 ◽  
Vol 20 (4) ◽  
pp. 23s-28s
Author(s):  
Rebecca Barresi ◽  
Emily Chen ◽  
I-Chien Liao ◽  
Xue Liu ◽  
Nada Baalbaki ◽  
...  

Author(s):  
Aiming Lu ◽  
Christopher P. Favazza ◽  
Joel P. Felmlee ◽  
Brian T. Welch ◽  
Lance A. Mynderse ◽  
...  

BIO-PROTOCOL ◽  
2021 ◽  
Vol 11 (10) ◽  
Author(s):  
Takashi Namba ◽  
Christiane Haffner ◽  
Wieland Huttner

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