Ethnopharmacological Relevance: Cortex Phellodendri Chinensis (CPC), a traditional Chinese medicine
known as “HuangBai” in China, are being widely employed as its health benefits. CPC has the function of
clearing heat and expelling dampness, purging fire and removing toxin, detumescencing and removing
necrotic tissue, which have the treatment for a variety of diseases.
Aim of The Study: The present review is intended to summarize the current researches on the
phytochemistry, pharmacological significances and medicinal uses of CPC, hoping to provide reference and
scientific basis for the research of bioactive ingredients, quality markers of CPC, as well as further
development and utilization in treatment of human diseases with CPC.
Materials and Methods: Extensive search of various documents and electronic databases such as Pubmed,
Royal Society of Chemistry, Science Direct, Springer, Web of Science, and Wiley, etc., were done to obtain
data. Other online academic libraries, e.g. Google Scholars, Scopus and national pharmacology literature
were also been employed to learn more information about CPC. Additional information was derived from
herbal classic books, Chinese pharmacopoeia, Postgraduate theses, China national knowledge internet, etc.
Results: The comprehensive analysis of the electronic database and literatures demonstrated that CPC is a
valuable herbal medicine with multiple pharmacological effects. Phytochemical and pharmacological
analysis indicated alkaloids are the major bioactive ingredients in CPC. However, there are no reports on
the research of quality markers of CPC, which means in a short time, there will emerge many studies to fill
this gap. Under the guidance of traditional Chinese medicines theory, CPC is usually combined with other
traditional Chinese medicines into prescriptions for various clinical use.
Conclusions: This review summarized the results from current researches about the basic characteristics of
CPC, such as bioactive constituents, pharmacological effect and mechanism of action, which are still being
studied and explored in order to realize the optimal medical practice. Meanwhile, it points out the existed
problems of the current researches of CPC and puts forward some suggestions for the future research of
CPC.