Religion assumes a conclusive role in vast parts of life, including creating inspiration and motivation in learning and constituting certain knowledge. Obviously, mathematics is a delicate subject for numerous students in any education level. By examining a religious role in term of mathematics and the obligation to learn about, religion may convey its importance in present-day, an era that requests high aptitude in mathematics. This study, utilizing library research method to exhibit relevant elements of religion, as inspiration and motivation, that can support the scholarly activities, particularly learning and developing mathematics idea in classroom. The notion of 'sacred science' from Seyyed Hossein Nasr was utilized to uncover the significant function of religion, particularly Islam, in looking for knowledge. Nasr considered that God, extraordinary preeminent entity, radiates in a profane world. Based on this idea, a motivation to embrace the ultimate reality and its numerical structure in nature is a type of intimacy to God. This writing demonstrates that religion still has its relevance in everyday scholastic exercises, including mathematics education. The teaching-learning process of mathematics will be increasingly meaningful for students by embeddings religion values as inspiration and motivation and considering its activities as a worship to .