Design and 3D-model of a dynamic bubble trap for cardiopulmonary bypass

The use of extracorporeal circulation systems (cardiopulmonary bypass pumps, ECMO) can lead to brain and coronary artery microembolism, which significantly reduces postoperative rehabilitation and often leads to severe complications. Microembolism occurs when oxygen or air microbubbles (MBs) enter the arterial system of patients. Existing CPB pumps come with built-in bubble trap systems but cannot remove bubbles in the circuit. ECMO devices have arterial filters but cannot reliably filter out <40 μm bubbles in a wide flow range. We have proposed an alternative method that involves the use of an efficient dynamic bubble trap (DBT) for both large and small bubbles. The design includes development of two DBT variants for hemodynamic conditions of adult and pediatric patients. The device is installed in the CPB pump and ECMO outlet lines. It provides sufficient bubble separation from the lines in a blood flow of 3.0–5.0 L/min for adults and 0.5–2.0 L/min for children. The developed computer models have shown that MBs smaller than 10 μm can be filtered. The use of this device will greatly reduce the likelihood of air embolism and provide the opportunity to reconsider the concept of expensive arterial filters.

Mapping the Bubble Trap Feeding Eruptions of Strokkur Geyser, Iceland

&lt;p&gt;Geysers are characterized by regular eruptions of hot water fountains. Their internal system consists of a heat source at depth, an often complex crack system and a conduit linking it to the surface. The conduit and crack system is filled with water, steam and gases similar to a volcano. Bubble traps are sometimes and rarely mapped and alternative heat-driven models for geyser eruptions exist.&lt;/p&gt;&lt;p&gt;Using a multidisciplinary, dense and close network of video cameras, seismometers, water pressure sensors and a tiltmeter we studied pool geyser Strokkur in June 2018. These multidisciplinary observations and particle-motion based tremor locations enabled us to derive a schematic cross section describing the driving mechanisms and the fluid dynamic processes within the bubble trap, crack system and conduit. We imaged a bubble trap at 23.7+-4.4 m depth, 13 to 23 m west of the conduit. We divide the eruptive cycle into eruption, refilling of the conduit, gas accumulation in the bubble trap and a trail of bubbles from the bubble trap into the conduit where they collapse at depth and have gained novel insights in understanding the gas accumulation, migration and collapse in such hot geyser systems in different phases of the eruptive cycle.&lt;/p&gt;&lt;p&gt;The dataset of this experiment can be accessed here:&lt;/p&gt;&lt;p&gt;&lt;strong&gt;- Eibl, E. P. S.&lt;/strong&gt;,&amp;#160;M&amp;#252;ller, D., Allahbakhshi, M., Walter, T. R., Jousset, P., Hersir, G. P., Dahm, T., (2020) ' Multidisciplinary dataset at the Strokkur Geyser, Iceland, allows to study internal processes and to image a bubble trap.' GFZ Data Services. DOI: 10.5880/GFZ.2.1.2020.007&lt;/p&gt;&lt;p&gt;- &lt;strong&gt;Eibl, E. P. S.&lt;/strong&gt;; Walter, T.; Jousset, P.; Dahm, T.; Allahbakhshi, M.; M&amp;#252;ller, D.; Hersir, G.P. (2020): 1 year seismological experiment at Strokkur in 2017/18. GFZ Data Services. Other/Seismic Network. DOI:10.14470/2Y7562610816&lt;/p&gt;

Development of a valve type semi-closed extracorporeal circulation system

In Japan, perfusionists who work on other clinical tasks are involved in cardiopulmonary bypass. Moreover, the number of cases they can perform is limited. In view of this situation, valve type semi-closed extracorporeal circulation (VACC) was developed as a system that enables extracorporeal circulation (ECC) regardless of perfusionists’ experience. The VACC circuit is based on a conventional open-type ECC circuit. A safety valve is installed at the outlet of the reservoir. It is closed by lowering the reservoir pressure below the venous circuit pressure (Pv), thereby providing a closed-type ECC in which the reservoir is separated from the venous circuit (V-circuit). A closed-type ECC needs means to cope with negative pressure generated in the V-circuit and to remove air mixed in the V-circuit. Water experiments to verify the safety of the VACC were conducted. In experiments simulating low venous return, when the Pv dropped, the safety valve opened so that the V-circuit was connected to the reservoir, and the excessive negative pressure was relieved. In the VACC circuit, a bubble trap is installed in the V-circuit, and the air is degassed to the reservoir by a roller pump (D-pump). A water experiment was conducted to verify the principle of the constant degassing method using the D-pump. It verified that the blood storage volume could be maintained constant even if the D-pump is continuously driven. The VACC system provides handling of air mixed in the V-circuit and safety in the case of low venous return.

Optimization of online particle counting with a 3D-printed bubble trap

Particulate evaluation is needed for the approval of cardiovascular devices. Air bubbles lead to higher particle counts when light obscuration method (LOM) is used. The aim of the study was to test a custom made bubble trap that removes air bubbles (2 - 100 μm) from a flow circuit prior to online particle counting. Artificially generated air bubbles were counted with an online particle counter with and without the bubble trap. Air bubbles were reduced by about 71 % to 91 % by using the bubble trap.