madelung's disease
Recently Published Documents





2022 ◽  
Vol 17 (2) ◽  
pp. 320-325
Jin Wanke ◽  
Fan Yongjing

2021 ◽  
Vol 4 (6) ◽  
pp. 29459-29465
Murilo Campos Silva ◽  
Diego de Souza Trevisan ◽  
Espedito Nobrega Braga Neto ◽  
Letícia Muniz Pereira ◽  
Luis Filipe Nagata Gasparini ◽  

Guilherme Felix Louza ◽  
Gláucia Zanetti ◽  
Edson Marchiori

2021 ◽  
Vol 9 (27) ◽  
pp. 8199-8206
Ling Wu ◽  
Ting Jiang ◽  
Yan Zhang ◽  
An-Qi Tang ◽  
Li-Hua Wu ◽  

2021 ◽  
Vol 14 (9) ◽  
pp. e243669
Shayan Soomro ◽  
Kimia Ziahosseini ◽  
Poonam Sharma

Madelung’s disease is a rare disorder characterised by excessive and symmetrical deposits of adipose tissue, typically in the cervicofacial region. Alcohol is a known cause of the condition, however, there are reports that this condition is genetically inherited. Lipomatosis of the orbit has been described in the alcoholic Madelung’s disease, however, in our case report, we believe this is the first reported instance of proptosis caused by the genetic form of the condition. We present a 69-year-old woman, with a medical history of genetic Madelung’s disease, who presented with bilateral proptosis worse in her right eye. Her ocular examination was normal apart from exophthalmometry, showing bilateral proptosis. This was confirmed by an MRI, which further showed intraorbital fat deposition bilaterally. Due to the stability of her condition, no treatment was deemed necessary. We highlight the importance of monitoring for progressive optic nerve compromise and liposarcomatous malignant transformation.

2021 ◽  
Vol 7 (8) ◽  
pp. 77508-77516
Tayná Carlos Rolim ◽  
Débora Jane Almeida Vianna Lins ◽  
Juliana Brasil De Oliveira ◽  
Ana Luisa Torres Fontes Lima

2021 ◽  
Vol 21 (1) ◽  
Yared Zenebe Zewde

Abstract Background Madelung’s disease (MD) is a rare disorder of fat storage characterized by the presence of diffuse, symmetrical deposition of subcutaneous fat around the neck, shoulder, arm, trunk and thigh. Although its cause is not fully understood, this benign condition is commonly presented among adult males with Mediterranean origin and history of alcohol abuse. Patients often presents with compression of vital structures, cosmetic disfigurement and associated psychosocial problems and systemic comorbidities. It is often under-recognized by physicians, possibly due to obliviousness of the condition and often misdiagnosed as obesity. Case presentation We present a 65-year-old non-alcoholic black Ethiopian man, presented with a slowly growing body fat in his trunk and proximal limbs associated by multiple joint and back pain which got worse recently. He denied any history of chronic alcohol use. On examination, huge, bilateral, non-tender, soft, globular masses in his torso, shoulder, arm and thigh with bilateral breast enlargement. On investigation his biochemical profile was normal except hyperuricemia (10.6 mg/dl). Imaging of the cervical and lumbar vertebrae showed excess subcutaneous fat depositions with degenerative disc disease. Biopsy from the mass revealed non-encapsulated lipoma and he was diagnosed with type II MD. We treated his pain with supportive therapy and discharged in stable condition. The patient deferred surgical treatment. Conclusions Madelung’s disease is often reported among white adult males with chronic alcoholism. However, our case reported a black man without the typical risk factor which was misdiagnosed as obesity. Hence, clinicians should be aware of MD and need to consider it in their differential diagnosis when encountered with a patient having progressive centripetal fat deposition with or without a history of alcoholism and systemic comorbidities. As early detection of this disorder helps to avoid diagnostic delays and prevent complications through timely interventions which will in turn improves patient quality of life.

Fabrizia Elli ◽  
Marco Stacchini ◽  
Alberto Daniele Arosio ◽  
Roberta Priola ◽  

Madelung’s Disease (MD), also known as benign multiple symmetric lipomatosis or Launois-Bensaude syndrome, is a rare condition. The characteristic feature is the presence of numerous diffuse lipomas at the level of the neck or upper limbs. The etiology is unknown, but a close association with ethyl abuse has been observed. The use of radiological examinations such as ultrasound, computed tomography and magnetic resonance imaging is helpful for the differential diagnosis. There are two classifications mainly used: The Enzi classification and the Donhauser classification. In this article we present a case of MD with laryngeal localization. A 50-year-old man was referred to our department complaining of dysphonia for about 6 months. An abnormal and diffuse enlargement of the anterior part of the neck was noticed, compatible with “Madelung’s Collar”. Fiberoptic examination of the larynx revealed the presence of a lipomatous-like neoformation of the left false vocal cord. The patient underwent surgical removal of the laryngeal neoformation with transoral laser microsurgery. With this article we suggest a possible diagnostic and therapeutic procedure for the treatment of laryngeal lipomatosis. Keywords: Lipoma; TML; Larynx; Dysphonia; ENT

Sign in / Sign up

Export Citation Format

Share Document