Automated Extraction of Cerebral Infarction Region in Head MR Image Using Pseudo Cerebral Infarction Image by CycleGAN

Since recognizing the location and extent of infarction is essential for diagnosis and treatment, many methods using deep learning have been reported. Generally, deep learning requires a large amount of training data. To overcome this problem, we generated pseudo patient images using CycleGAN, which performed image transformation without paired images. Then, we aimed to improve the extraction accuracy by using the generated images for the extraction of cerebral infarction regions. First, we used CycleGAN for data augmentation. Pseudo-cerebral infarction images were generated from healthy images using CycleGAN. Finally, U-Net was used to segment the cerebral infarction region using CycleGAN-generated images. Regarding the extraction accuracy, the Dice index was 0.553 for U-Net with CycleGAN, which was an improvement over U-Net without CycleGAN. Furthermore, the number of false positives per case was 3.75 for U-Net without CycleGAN and 1.23 for U-Net with CycleGAN, respectively. The number of false positives was reduced by approximately 67% by introducing the CycleGAN-generated images to training cases. These results indicate that utilizing CycleGAN-generated images was effective and facilitated the accurate extraction of the infarcted regions while maintaining the detection rate.

Machine learning for financial forecasting, planning and analysis: recent developments and pitfalls

This article is an introduction to machine learning for financial forecasting, planning and analysis (FP&A). Machine learning appears well suited to support FP&A with the highly automated extraction of information from large amounts of data. However, because most traditional machine learning techniques focus on forecasting (prediction), we discuss the particular care that must be taken to avoid the pitfalls of using them for planning and resource allocation (causal inference). While the naive application of machine learning usually fails in this context, the recently developed double machine learning framework can address causal questions of interest. We review the current literature on machine learning in FP&A and illustrate in a simulation study how machine learning can be used for both forecasting and planning. We also investigate how forecasting and planning improve as the number of data points increases.

Automated extraction of revision events from keystroke data

Revision plays an important role in writing, and as revisions break down the linearity of the writing process, they are crucial in describing writing process dynamics. Keystroke logging and analysis have been used to identify revisions made during writing. Previous approaches include the manual annotation of revisions, building nonlinear S-notations, and the automated extraction of backspace keypresses. However, these approaches are time-intensive, vulnerable to construct, or restricted. Therefore, this article presents a computational approach to the automatic extraction of full revision events from keystroke logs, including both insertions and deletions, as well as the characters typed to replace the deleted text. Within this approach, revision candidates are first automatically extracted, which allows for a simplified manual annotation of revision events. Second, machine learning is used to automatically detect revision events. For this, 7120 revision events were manually annotated in a dataset of keystrokes obtained from 65 students conducting a writing task. The results showed that revision events could be automatically predicted with a relatively high accuracy. In addition, a case study proved that this approach could be easily applied to a new dataset. To conclude, computational approaches can be beneficial in providing automated insights into revisions in writing.

NERO: a biomedical named-entity (recognition) ontology with a large, annotated corpus reveals meaningful associations through text embedding

Machine reading (MR) is essential for unlocking valuable knowledge contained in millions of existing biomedical documents. Over the last two decades1,2, the most dramatic advances in MR have followed in the wake of critical corpus development3. Large, well-annotated corpora have been associated with punctuated advances in MR methodology and automated knowledge extraction systems in the same way that ImageNet4 was fundamental for developing machine vision techniques. This study contributes six components to an advanced, named entity analysis tool for biomedicine: (a) a new, Named Entity Recognition Ontology (NERO) developed specifically for describing textual entities in biomedical texts, which accounts for diverse levels of ambiguity, bridging the scientific sublanguages of molecular biology, genetics, biochemistry, and medicine; (b) detailed guidelines for human experts annotating hundreds of named entity classes; (c) pictographs for all named entities, to simplify the burden of annotation for curators; (d) an original, annotated corpus comprising 35,865 sentences, which encapsulate 190,679 named entities and 43,438 events connecting two or more entities; (e) validated, off-the-shelf, named entity recognition (NER) automated extraction, and; (f) embedding models that demonstrate the promise of biomedical associations embedded within this corpus.

More than a biomarker: could language be a biosocial marker of psychosis?

Automated extraction of quantitative linguistic features has the potential to predict objectively the onset and progression of psychosis. These linguistic variables are often considered to be biomarkers, with a large emphasis placed on the pathological aberrations in the biological processes that underwrite the faculty of language in psychosis. This perspective offers a reminder that human language is primarily a social device that is biologically implemented. As such, linguistic aberrations in patients with psychosis reflect both social and biological processes affecting an individual. Failure to consider the sociolinguistic aspects of NLP measures will limit their usefulness as digital tools in clinical settings. In the context of psychosis, considering language as a biosocial marker could lead to less biased and more accessible tools for patient-specific predictions in the clinic.