KnowMore: an automated knowledge discovery tool for the FAIR SPARC datasets

Background: This manuscript provides the methods and outcomes of KnowMore, the Grand Prize winning automated knowledge discovery tool developed by our team during the 2021 NIH SPARC FAIR Data Codeathon. The National Institutes of Health Stimulating Peripheral Activity to Relieve Conditions (NIH SPARC) program generates rich datasets from neuromodulation researches, curated according to the Findable, Accessible, Interoperable, and Reusable (FAIR) SPARC data standards. Currently, the process of simultaneously comparing and analyzing multiple SPARC datasets is tedious because it requires investigating each dataset of interest individually and downloading all of them to conduct cross-analyses. It is crucial to enhance this process to enable rapid discoveries across SPARC datasets. Methods: To fill this need, we created KnowMore, a tool integrated into the SPARC Portal that only requires the user to select their datasets of interest to launch an automated discovery process. KnowMore uses several SPARC resources (Pennsieve, o²S²PARC, SciCrunch, protocols.io, Biolucida), data science methods, and machine learning algorithms in the back end to generate various visualizations in the front end intended to help the user identify potential similarities, differences, and relations across the datasets. These visualizations can lead to a new discovery, new hypothesis, or simply guide the user to the next logical step in their discovery process. Results: The outcome of this project is a SPARC portal-ready code architecture that helps researchers to use SPARC datasets more efficiently and fully leverages their FAIR characteristics. The tool has been built and documented such that more data analysis methods and visualization items could be easily added. Conclusions: The potential for automated discoveries from SPARC datasets is huge given the unique SPARC data ecosystem promoting FAIR data practices, and KnowMore has only demonstrated a small highlight of what could be achieved to speed up discoveries from SPARC datasets.

NERO: a biomedical named-entity (recognition) ontology with a large, annotated corpus reveals meaningful associations through text embedding

Machine reading (MR) is essential for unlocking valuable knowledge contained in millions of existing biomedical documents. Over the last two decades1,2, the most dramatic advances in MR have followed in the wake of critical corpus development3. Large, well-annotated corpora have been associated with punctuated advances in MR methodology and automated knowledge extraction systems in the same way that ImageNet4 was fundamental for developing machine vision techniques. This study contributes six components to an advanced, named entity analysis tool for biomedicine: (a) a new, Named Entity Recognition Ontology (NERO) developed specifically for describing textual entities in biomedical texts, which accounts for diverse levels of ambiguity, bridging the scientific sublanguages of molecular biology, genetics, biochemistry, and medicine; (b) detailed guidelines for human experts annotating hundreds of named entity classes; (c) pictographs for all named entities, to simplify the burden of annotation for curators; (d) an original, annotated corpus comprising 35,865 sentences, which encapsulate 190,679 named entities and 43,438 events connecting two or more entities; (e) validated, off-the-shelf, named entity recognition (NER) automated extraction, and; (f) embedding models that demonstrate the promise of biomedical associations embedded within this corpus.

Literature Mining and Mechanistic Graphical Modelling to Improve mRNA Vaccine Platforms

RNA vaccines represent a milestone in the history of vaccinology. They provide several advantages over more traditional approaches to vaccine development, showing strong immunogenicity and an overall favorable safety profile. While preclinical testing has provided some key insights on how RNA vaccines interact with the innate immune system, their mechanism of action appears to be fragmented amid the literature, making it difficult to formulate new hypotheses to be tested in clinical settings and ultimately improve this technology platform. Here, we propose a systems biology approach, based on the combination of literature mining and mechanistic graphical modeling, to consolidate existing knowledge around mRNA vaccines mode of action and enhance the translatability of preclinical hypotheses into clinical evidence. A Natural Language Processing (NLP) pipeline for automated knowledge extraction retrieved key biological evidences that were joined into an interactive mechanistic graphical model representing the chain of immune events induced by mRNA vaccines administration. The achieved mechanistic graphical model will help the design of future experiments, foster the generation of new hypotheses and set the basis for the development of mathematical models capable of simulating and predicting the immune response to mRNA vaccines.

WisdomModel: convert data into wisdom

PurposeTraditional classification algorithms always have an incorrect prediction. As the misclassification rate increases, the usefulness of the learning model decreases. This paper presents the development of a wisdom framework that reduces the error rate to less than 3% without human intervention.Design/methodology/approachThe proposed WisdomModel consists of four stages: build a classifier, isolate the misclassified instances, construct an automated knowledge base for the misclassified instances and rectify incorrect prediction. This approach will identify misclassified instances by comparing them against the knowledge base. If an instance is close to a rule in the knowledge base by a certain threshold, then this instance is considered misclassified.FindingsThe authors have evaluated the WisdomModel using different measures such as accuracy, recall, precision, f-measure, receiver operating characteristics (ROC) curve, area under the curve (AUC) and error rate with various data sets to prove its ability to generalize without human involvement. The results of the proposed model minimize the number of misclassified instances by at least 70% and increase the accuracy of the model minimally by 7%.Originality/valueThis research focuses on defining wisdom in practical applications. Despite of the development in information system, there is still no framework or algorithm that can be used to extract wisdom from data. This research will build a general wisdom framework that can be used in any domain to reach wisdom.

KnowMore: An Automated Knowledge Discovery Tool for the FAIR SPARC Datasets

This manuscript provides the methods and outcomes of KnowMore, the Grand Prize winning automated knowledge discovery tool developed by our team during the 2021 NIH SPARC FAIR Data Codeathon. The NIH SPARC program generates rich datasets from neuromodulation researches, curated according to the Findable, Accessible, Interoperable, and Reusable (FAIR) SPARC data standards. These datasets are publicly available through the SPARC Data Portal at sparc.science. Currently, the process of simultaneously comparing and analyzing multiple SPARC datasets is tedious because it requires investigating each dataset of interest individually and downloading all of them to conduct cross-analyses. It is crucial to enhance this process to enable rapid discoveries across SPARC datasets. To fill this need, we created KnowMore, a tool integrated into the SPARC Portal that only requires the user to select their datasets of interest to launch an automated discovery process. KnowMore uses several SPARC resources (Pennsieve, o2S2PARC, SciCrunch, protocols.io, Biolucida), data science methods, and Machine Learning algorithms in the back end to generate various visualizations in the front end intended to help the user identify potential similarities, differences, and relations across the datasets. These visualizations can lead to a new discovery, new hypothesis, or simply guide the user to the next logical step in their discovery process. The outcome of this project is a SPARC portal-ready code architecture that helps researchers to use SPARC datasets more efficiently and fully leverages their FAIR characteristics. The tool has been built and documented such that more data analysis methods and visualization items could be easily added. The potential for automated discoveries from SPARC datasets is huge given the unique SPARC data ecosystem promoting FAIR data practices, and KnowMore has only demonstrated a small highlight of what could be achieved to speed up discoveries from SPARC datasets.

A Knowledge Graph of Mechanistic Associations Between COVID-19, Diabetes Mellitus and Kidney Diseases

This paper proposes an automated knowledge synthesis and discovery framework to analyze published literature to identify and represent underlying mechanistic associations that aggravate chronic conditions due to COVID-19. We present a literature-based discovery approach that integrates text mining, knowledge graphs and ontologies to discover semantic associations between COVID-19 and chronic disease concepts that were represented as a complex disease knowledge network that can be queried to extract plausible mechanisms by which COVID-19 may be exacerbated by underlying chronic conditions.

DEVELOPMENT OF PRINCIPLES AND MEANS OF DIAGNOSTICS OF COMPETENCIES FORMED WHEN STUDYING DISCIPLINES OF THE MATHEMATICAL PROFILE IN STUDENTS OF TECHNICAL SPECIALTIES

The state of solving the problem of formation of mathematical competencies in the study of mathematical disciplines in technical students is clarified. Approaches to the diagnosis of mathematical training of students in the process of teaching mathematical disciplines at the university, which provide continuous, objective and timely information about the current level of mathematical training of students, as well as gaps and shortcomings in the formation of mathematical competence. The goals of diagnostics are formulated, which should reflect the structure and content of mathematical competence as a result of mathematical training. In the structure of mathematical competence, in accordance with the content of mathematical activity, it is appropriate to consider: possession of heuristic methods of finding solutions to problems; possession of methods for solving problems; knowledge of methods of mathematical modeling, application of mathematics in other areas. The analysis of prospects of application of automation of process of estimation of knowledge of students on the basis of computer testing is carried out that gives the chance to receive the full information on process and results of mathematical preparation of students, increase of motivation of their cognitive activity, development of reflection and skills of self-diagnostics. The advantages and disadvantages of using automated knowledge control systems are considered. With the help of such systems the differentiation of educational material is carried out, the interrogation providing objectivity of diagnostics of knowledge is carried out, results of training of students are fixed. Automated systems are focused on in-depth assimilation of information individually by each student.