Tissue distribution and cellular localization of gold nanocarriers with bound oligonucleotides

Aim: The aim of the study was to determine how the addition of a DNA oligonucleotide cargo to 3-nm gold glyconanoparticles would affect tissue distribution. Methods: Gold glyconanoparticles with 1–6 covalently bound oligonucleotides (40 nt dsDNA) were injected into rats and allowed to circulate for 10 min. Organs were harvested and gold quantitated by inductively coupled plasma mass spectrometry. Cellular localization of the nanocarriers was determined by electron microscopy. Results & conclusion: Addition of DNA cargo to the nanocarriers prevented localization in the kidney but increased localization in liver hepatocytes and splenic macrophages. There was no significant change in heart, lung or brain. DNA increases the size and adds a strong negative charge to the nanoparticles, which radically affects tissue distribution.

Facile in situ synthesis of ultrasmall near-infrared-emitting gold glyconanoparticles with enhanced cellular uptake and tumor targeting

Ultrasmall gold glyconanoparticles with enhanced tumor-targeting efficiency and efficient clearance through both renal and hepatobiliary pathways.

Multimerization of DAB-1 onto Au GNPs affords new potent and selective N-acetylgalactosamine-6-sulfatase (GALNS) inhibitors

Gold glyconanoparticles (Au GNPs) decorated with the natural iminosugar DAB-1 at different densities are reported.

Gold glyconanoparticles coupled to listeriolysin O 91–99 peptide serve as adjuvant therapy against melanoma

Dendritic cell-based (DC-based) vaccines are promising immunotherapies for cancer.

N-Oxyamide-linked glycoglycerolipid coated AuNPs for receptor-targeting imaging and drug delivery

We report the construction of gold glyconanoparticles coated by N-oxyamide-linked glycoglycerolipids for receptor-targeting imaging and drug delivery.