The contribution of galenics to patients’ sensory perception of nasal sprays after nasal surgery – data from a prospective randomized, controlled, double-blind, cross-over, multi-centre study

Introduction:Postoperative care after nasal surgery is commonly achieved with nasal sprays. The current study compared two decongesting, wound healing nasal sprays in patients after nasal surgery in order to investigate their sensoric perception. One of the sprays presented a new galenic formulation (nasic® neo, Cassella-med GmbH & Co. KG).Methods:Using a cross-over design, patients who had undergone nasal surgery applied two different nasal sprays during two treatment periods of 4 days each, interrupted by 3 days wash out period. Sensoric perception of the nasal sprays was assessed with the nasal-spray-sensoric-scale. Throughout the study, nasal obstruction was evaluated by patients, and physical examinations, measurements of vital parameters and rhinoscopic examinations were carried out by investigators. Adverse events were documented during the entire study, and following treatment, patients judged the overall preference, efficacy and tolerability of both products.Results:Overall, no significant differences in sum scores of the assessments of the nasal-spray-sensoric-scale were observed between treatments. Significant periodic effect observed during the cross-over study limited the overall analysis. Nevertheless, it could be shown that significantly more patients preferred the new galenics nasal spray compared to the comparator spray (57.1% vs. 34.7%; p=0.031). Further, 10% more patients rated the efficacy of new galenics as ‘good’ to ‘very good’ compared to the comparator. Importantly, a subgroup population of patients with more pronounced signs of inflammation present at screening evaluated the sensoric perception of new galenics significantly better (p=0.033) compared to the comparator. Within this subgroup, no periodic effect was observed. The application of both nasal sprays was shown to be safe and well-tolerated.Conclusion:The current study showed that the overall sensoric perception of both nasal sprays was evaluated comparably well in patients after nasal surgery and that overall, the application of the new galenics nasal spray was preferred by significantly more patients compared to the comparator nasal spray. Patients with marked nasal abnormalities may have a greater benefit from the contribution of galenics as significant differences in the sensoric evaluation by the nasal-spray-sensoric-scale in favour of the new galenics product were shown for this subgroup.Trial registration: The current study was registered in the EU Clinical Trials Register with the EudraCT No: 2019-004936-52.

A simulation study of processes for mixing non-isothermal flows under dynamic effects

The processes for mixing of non-isothermal streams essentially define the parameters of the heat-carrier on an input in a core in modes with incomplete structure of the working equipment and, as a consequence, - a heat engineering condition of a core. Besides, the task of researching the temperature pulsations accompanying practically all modes of currents for non-isothermal streams is extremely relevant, as these pulsations lead to additional thermocyclic loadings on elements of the equipment and in many cases define its resource. The paper describes the research of mixing processes for non-isothermal water coolant flows in hydraulic model of ship nuclear power plant. In several experiments, attention was paid to the mixing processes when feeding non-isothermal flows through the circulation loops located opposite of each other. To simulate the effect of external dynamic force in the form of periodic effect on the spatial orientation of the model, the ship was tested on a stand "Swinging platform". These vibrations affected the mixing processes occurring within the model. The main impact they had on the transition time, temperature gradient, vertical component of the velocity projection. In the future, these parameters will be clarified and the influence of other factors on the mixing of non-isothermal flows in the ship's nuclear power plant will be studied in more detail.

Structural, electronic, vibrational and optical properties of Bin clusters

The neutral, anionic and cationic bismuth clusters with the size n up to 14 are investigated by using B3LYP functional within the regime of density functional theory and the LAN2DZ basis set. By analysis of the geometries of the Bi[Formula: see text] (n = 2–14) clusters, where cationic and anionic bismuth clusters are largely similar to those of neutral ones, a periodic effect by adding units with one to four atoms into smaller cluster to form larger cluster is drawn for the stable structures of bismuth clusters. An even–odd alteration is shown for the properties of the clusters, such as the calculated binding energies and dissociation energies, as well as frontier orbital energies, electron affinities, ionization energies. All the properties indicate that the Bi4 cluster is the most possible existence in bismuth-containing materials, which supports the most recent experiment. The orbital compositions, infrared and Raman activities and the ultraviolet absorption of the most possible tetramer bismuth cluster are given in detail to reveal the periodic tendency of adding bismuth atoms and the stability of tetramer bismuth cluster.

Periodic solution to general conduction problems

In this paper, we present a modified exp-function method, where hyperbolic cosine and cosine functions are used. The hyperbolic cosine functions are responsible for energy localization while cosine functions reveal the periodic effect. A general conduction problem is used as an example to illustrate the solution process.