Cerebral venous sinus thrombosis (CVST) associated with SARS-CoV-2 vaccines: clues for an immunopathogenesis common to CVST observed in COVID-19

Severe acute respiratory syndrome coronavirus type 2 has been responsible for an unprecedented pandemic, and nowadays, several vaccines proved to be effective and safe, representing the only available strategy to stop the pandemic. While millions of people have safely received vaccine, rare and unusual thrombotic events have been reported and are undergoing investigations to elucidate their nature. Understanding initial trigger, underlying pathophysiology and the reasons for specific site localization of thrombotic events are a matter of debate.We here propose that rare cases of cerebral venous sinus thrombosis, a clinical event that may rapidly evolve to brain death, reported after COVID-19 vaccine, might be consequent to an immune response resulting in inflamed/damaged endothelium, an event similar to that described for cases of cerebral venous sinus thrombosis reported during COVID-19 and not necessarily related to anti-Platelets Factor 4 antibodies, as recently described. Remarkably, in the two patients presenting at our hospital with cerebral venous sinus thrombosis and evolved to brain death, proper tissue perfusion and function maintenance allowed organ donation despite extensive thrombosis in the organ donors, with favorable outcome at 6 months.Increased vigilance, close multidisciplinary collaboration, and further prospective research will help to better elucidate a very rare and still not fully understood pathophysiological event associated with vaccines for severe acute respiratory syndrome coronavirus 2.

Inter in Iran: Theory and Practice of Web Site Localization

<p>In an increasingly globalized world, web site localization has rapidly become an important form of cross-cultural and multimodal translation. The current pandemic has poignantly demonstrated how crucial multilingual web sites are to all aspects of life – from healthcare to education, from business to sport. The localization of football clubs’ web sites, however, has received very little attention in terms of academic research. As any other brands with local and global markets, football clubs rely on multilingual and multimodal communications to reach wider audience and increase their profile as well as their revenue. Most of the internet users in the world are non-native English speakers. The relevance of this data also applies to the most popular game in the world, football, and ought to be taken into serious consideration by football clubs in shaping their profile and priorities in terms of identity and outreach. The aim of this interdisciplinary thesis – one of the first academic studies worldwide devoted to the theory and practice of football club web site localization, especially in the context of Iran, where interest in national and international football is constantly growing – was thus to investigate how accurate and cross-culturally appropriate the translation of leading football clubs’ web site content actually is. This research project was conceptualized and conducted as a mixed-method case study to generate and combine quantitative and qualitative data in order to analyse and assess the translation and intercultural communication strategies adopted by some of the top football to produce multilingual web site content. Gathered data has been used to establish a set of theoretical principles and practical guidelines to help not only web site localizers and translation scholars but also media consultants and marketing analysts acquire a deeper understanding of how crucial translation quality and cross-cultural competence are – all the more so when localizing into a such a unique language as culture that is far-removed from the source language and culture. The theoretical and practical rubric I have devised has then been tested by translating into Persian selected pages from the web site of Football Club Internazionale Milano, one of the most international (as its name attests) and globally-minded as well as successful football clubs in the world. The findings of this study demonstrate that football clubs ought to consider linguistic and cultural accuracy, alongside up-to-date technology and appealing content, as key factors in achieving not only effective communication but also short-term and long-term success on and off the field.</p>

Inter in Iran: Theory and Practice of Web Site Localization

<p>In an increasingly globalized world, web site localization has rapidly become an important form of cross-cultural and multimodal translation. The current pandemic has poignantly demonstrated how crucial multilingual web sites are to all aspects of life – from healthcare to education, from business to sport. The localization of football clubs’ web sites, however, has received very little attention in terms of academic research. As any other brands with local and global markets, football clubs rely on multilingual and multimodal communications to reach wider audience and increase their profile as well as their revenue. Most of the internet users in the world are non-native English speakers. The relevance of this data also applies to the most popular game in the world, football, and ought to be taken into serious consideration by football clubs in shaping their profile and priorities in terms of identity and outreach. The aim of this interdisciplinary thesis – one of the first academic studies worldwide devoted to the theory and practice of football club web site localization, especially in the context of Iran, where interest in national and international football is constantly growing – was thus to investigate how accurate and cross-culturally appropriate the translation of leading football clubs’ web site content actually is. This research project was conceptualized and conducted as a mixed-method case study to generate and combine quantitative and qualitative data in order to analyse and assess the translation and intercultural communication strategies adopted by some of the top football to produce multilingual web site content. Gathered data has been used to establish a set of theoretical principles and practical guidelines to help not only web site localizers and translation scholars but also media consultants and marketing analysts acquire a deeper understanding of how crucial translation quality and cross-cultural competence are – all the more so when localizing into a such a unique language as culture that is far-removed from the source language and culture. The theoretical and practical rubric I have devised has then been tested by translating into Persian selected pages from the web site of Football Club Internazionale Milano, one of the most international (as its name attests) and globally-minded as well as successful football clubs in the world. The findings of this study demonstrate that football clubs ought to consider linguistic and cultural accuracy, alongside up-to-date technology and appealing content, as key factors in achieving not only effective communication but also short-term and long-term success on and off the field.</p>

Mid-Holocene Palaeoenvironment, Plant Resources and Human Interaction in Northeast Iberia: An Archaeobotanical Approach

The role of the adoption of farming economies in the transformation of mid-Holocene landscapes in Northeast Iberia is under discussion given that the Neolithization coincides with the cold climatic phase dated ca. 7500–7000 cal BP. The main aim of this paper is to assess whether human activities or climate were the main driver of vegetation changes during the Middle Holocene through the study of the archaeobotanical data from three case studies: Cova del Sardo, La Draga, and Coves del Fem. The application of diverse archaeobotanical techniques to the different plant remains provides a complete picture of the vegetation composition and plant uses. During the early Neolithic, settlement surroundings were intensively exploited for firewood, wood raw material, timber, and plant fibers. The resources were obtained mainly from deciduous and pine forests, depending on the site localization, but also from riparian zones. The diversity of plants exploited was high, not only trees but shrubs and herbs. Evidence of deforestation has been identified in the settlement surroundings in La Draga and Cova del Sardo. The combination of plant exploitation with other agropastoral activities favored the expansion of colonizing species and enhanced biodiversity at a local scale.

Functional characterization of TANGLED1 interaction with PHRAGMOPLAST ORIENTING KINESIN1 during mitosis in Arabidopsis

Cell division requires spatial coordination to properly position the division plane. How division plane positioning contributes to plant growth remains unknown. Two unrelated microtubule binding proteins, TANGLED1 (TAN1) and AUXIN-INDUCED-IN-ROOT-CULTURES9 (AIR9), are together required for normal Arabidopsis growth and division. tan1 air9 double mutants have synthetic growth and division plane orientation defects while single mutants lack obvious defects. We show that the first 132 amino acids of TAN1 (TAN1(1-132)) rescue the tan1 air9 double mutant and localize to the division site during telophase. Loss of both rescue and division-site localization occurred when interaction between TAN1 and PHRAGMOPLAST ORIENTING KINESIN1 (POK1) was disrupted by replacing six amino acid residues with alanines in TAN1(1-132). However, full-length TAN1 with the same alanine substitutions significantly rescued the tan1 air9 double mutant and remained at the division site throughout mitosis, although its accumulation was reduced and phragmoplast positioning defects occurred. POK1 often fails to accumulate at the division site in tan1 air9 mutants, suggesting that both TAN1 and AIR9 stabilize POK1 there. Finally, a mitosis specific promoter driving TAN1 rescued the tan1 air9 double mutant phenotypes indicating that defects seen in the root differentiation zone reflect the loss of mitotic-specific TAN1 activity.

Qualidade da Água e Hidrodinâmica como Parâmetros Ambientais na Piscicultura de Tanques-Rede no Estuário do Rio Amazonas

The cultivation of fish in net cages is an activity sensitive to environmental pollution, but also has the ability to cause environmental impact. The aim of study was to investigate spatial-temporal variations of physico-chemical and microbiological parameters of water quality (WQ) in a stretch of the Matapi River, State of Amapá/Brazil. This study presents an environmental analysis of fish culture on net cages systems, specially hydrodynamic and WQ condictions. Three sampling sites were distributed in ≈15 km of river to quantify variations of the WQ and hydrodynamic parameters. We notice a significant hydrodynamic seasonal influence of the WQ (p <0.05), which presented reduced spatial influence (p>0.05). We observed that both the hydrological-seasonal condictions, tide phase and site localization, explain the variation of WQ in these floodplans area (p<0.05, ANCOVA). We conclude that net cage system presented low environmental impact but local viability, both dependent on hydrodynamic conditions and scale studied.

Binding site localization on non-homogeneous cell surfaces using topological image averaging

Antibody binding to cell surface proteins plays a crucial role in immunity and the location of an epitope can altogether determine the immunological outcome of a host-target interaction. Techniques available today for epitope identification are costly, time-consuming, and unsuited for high-throughput analysis. Fast and efficient screening of epitope location can be useful for the development of therapeutic monoclonal antibodies and vaccines. In the present work, we have developed a method for imaging-based localization of binding sites on cellular surface proteins. The cellular morphology typically varies, and antibodies often bind in a non-homogenous manner, making traditional particle-averaging strategies challenging for accurate native antibody localization. Nanometer-scale resolution is achieved through localization in one dimension, namely the distance from a bound ligand to a reference surface, by using topological image averaging. Our results show that this method is well suited for antibody binding site measurements on native cell surface morphology.