In living sistems synthesis of nitric oxide occurs during metabolism from
Larginin, nitrite and ascorbate. Being very significant carrier of
information within numerous both physiological and pathological proceses in
mammals' organisms, nitric oxid could possibly be useful as well as harmful.
Nitric oxide synthesis is adjuvant in a healthy organism because it
represents the basic molecule for understanding numerous processes in
neurology, psychology, immunology and varios related fields. In other words,
nitric oxide participate in number of physiological processes, such as:
transmission of nerve signals (neurotransmitter role), regulation of smooth
muscle tissue relaxation (eg. vasodilatation), peristaltic movements,
immunomodulation, mastocyte activation, development of inflammatory response,
apoptosis regulation, angiogenesis and glucose metabolism, normal heart
functioning and antioxidation role. Besides being useful, nitric oxide can be
harmful as well, because it has one unpaired electron, so consequently it is
susceptible to oxidation becoming a stable free radical. Being such, it
reacts quickly with superoxide-anion radical, givind at first an extremely
reactive peroxinitrite anion, and subsequently peroxidnitrite acid. This acid
is very dangerous causing thiol groups oxidation, tyrosine and phenylalanine
nitrosylation, lipid oxidation, DNK chain splitting, nitrification and
nucleic bases deamination. These damages of macromolecules can cause a series
of undesirable changes which subsequently distub functions of molecules, and
thus of cells, tissues and even organs.