The dangers of recreational inhalation of nitrous oxide

Nitrous oxide, also known as ‘laughing gas’, is one of the most widely used recreational drugs among teenagers in the UK. Copious inhalation of nitrous oxide may increase intra-alveolar pressure, resulting in barotrauma secondary to alveolar rupture. Pneumomediastinum and subcutaneous emphysema are common clinical findings in nitrous oxide-associated barotrauma. Prolonged nitrous oxide misuse may inactivate vitamin B12 through the alteration of its metabolism, causing demyelination of the central and peripheral nervous system. A spectrum of neurological manifestations has been reported, including peripheral neuropathy, myelopathy and subacute combined degeneration of the spinal cord. Medical therapies and psychosocial interventions aiming at nitrous oxide cessation are important treatment steps to achieve partial or complete recovery from the adverse effects associated with inhalation of nitrous oxide.

Current experimental developments in 48 V-based CI-driven SUVs in response to expected future EU7 legislation

In this paper, we describe experimental developments in an Exhaust Aftertreatment System (EAS) used in a four-cylinder Compression Ignition (CI) engine. To meet the carbon dioxide (CO$$_\mathrm {2}$$ 2 ) fleet limit values and to demonstrate a clean emission concept, the CI engine needs to be further developed in a hybridized, modern form before it can be included in the future fleet. In this work, the existing EAS was replaced by an Electrically Heated Catalyst (EHC) and a Selective Catalytic Reduction (SCR) double-dosing system. We focused specifically on calibrating the heating modes in tandem with the electric exhaust heating, which enabled us to develop an ultra-fast light-off concept. The paper first outlines the development steps, which were subsequently validated using the Worldwide harmonized Light-duty vehicles Test Cycle (WLTC). Then, based on the defined calibration, a sensitivity analysis was conducted by performing various dynamic driving cycles. In particular, we identified emission species that may be limited in the future, such as laughing gas (N$$_\mathrm {2}$$ 2 O), ammonia (NH$$_\mathrm {3}$$ 3 ), or formaldehyde (HCHO), and examined the effects of a general, additional decrease in the limit values, which may occur in the near future. This advanced emission concept can be applied when considering overall internal engine and external exhaust system measures. In our study, we demonstrate impressively low tailpipe (TP) emissions, but also clarify the system limits and the necessary framework conditions that ensure the applicability of this drivetrain concept in this sector.

The action of laughing gas in the treatment of the mountain sun

The physiological effects produced by the artificial mountain sun include, among other things, lowering blood pressure. Kestner attributes this to the effect of inhalation of nitrous oxide (N2O), which is produced by electrical discharge. Pollitzer and Stolz (Mnch, m. Woch, 1924, no. 29) set themselves the goal of resolving the following questions:

July 25 — the Day of the Dental Technician

Healthy teeth are the key to the normal functioning of the whole organism; people should start taking care of the condition of their teeth from early childhood. It is the teeth that are the only organ of the human body that is incapable of regeneration, so they need special care and the most careful attitude. Not everyone regularly visits dentists, and very few are closely familiar with the work of their right-hand people — dental technicians. At the beginning of the 18th century, serious changes took place in the field of dentistry, i.e. the transition from conservative tooth extraction to the desire for their maximum preservation and restoration. Pierre Fauchard is considered the ideological inspirer of scientific dentistry. By the way, it is dentists who are most directly related to the formation of another scientific discipline — anesthesiology. The first experiments with anesthetics — nitrous oxide (laughing gas) and sulfuric ether — began to be used by dentists as early as the 19th century. It was then that the English naturalist H. Davy experienced the pain-dulling effect of nitrous oxide fumes, and in the 40s of the same century, another dentist had a tooth removed for the first time under the influence of «laughing gas». Many people are used to calling stomatologists dentists, but this broad concept unites not only dentists and surgeons, but also feldshers and technicians. Each individual direction requires a highly qualified specialist, serious practical experience and excellent work skills.

Nitrous Oxide-Induced Neuropathy among Recreational Users in Vietnam

Nitrous oxide (N2O) commonly referred to as laughing gas, has significant medical uses. This study aims to describe the neurological disorders associated with N2O. We conducted across-sectional study that enrolled patients with nitrous oxide toxicity admitted to Vietnam Poison Control Center, Bach Mai Hospital, Hanoi, Vietnam from June 2018 to July 2019. The questionnaire included demographic characteristics, characteristics of using N2O, signs and clinical symptoms, neuroimaging findings, injury on electromyography (EMG) and the Total Neuropathy Score clinical version (TNSc) criteria. A total of 47 participants were included with mean age: 24.38 ± 6.20 years. The number of balloons used per week was 130.59 ± 117.43. The mean duration of N2O exposure was 8.79 ± 7.1 months. Multivariate linear logistic regression revealed that the number of N2O balloons used per week was significantly associated with TNSc point (Beta: 0.315; 95% CI: 0.001–0.022). We found that myeloneuropathy and peripheral neuropathy were the main neurological disorders related to N2O abuse, which should improve the awareness of the appearance of neurological disorders associated with N2O abuse.

Problematic Use of Nitrous Oxide by Young Moroccan–Dutch Adults

The recreational use of nitrous oxide (N2O; laughing gas) has largely expanded in recent years. Although incidental use of nitrous oxide hardly causes any health damage, problematic or heavy use of nitrous oxide can lead to serious adverse effects. Amsterdam care centres noticed that Moroccan–Dutch young adults reported neurological symptoms, including severe paralysis, as a result of problematic nitrous oxide use. In this qualitative exploratory study, thirteen young adult Moroccan–Dutch excessive nitrous oxide users were interviewed. The determinants of problematic nitrous oxide use in this ethnic group are discussed, including their low treatment demand with respect to nitrous oxide abuse related medical–psychological problems. Motives for using nitrous oxide are to relieve boredom, to seek out relaxation with friends and to suppress psychosocial stress and negative thoughts. Other motives are depression, discrimination and conflict with friends or parents. The taboo culture surrounding substance use—mistrust, shame and macho culture—frustrates timely medical/psychological treatment of Moroccan–Dutch problematic nitrous oxide users. It is recommended to use influencers in media campaigns with the aim to decrease the risks of heavy nitrous oxide use and improve treatment access. Outreach youth workers can also play an important role in motivating socially isolated users to seek medical and or psychological help.