Self-Protection as an Adaptive Female Strategy

Many male traits are well explained by sexual selection theory as adaptations to mating competition and mate choice, whereas no unifying theory explains traits expressed more in females. Anne Campbell's “staying alive” theory proposed that human females produce stronger self-protective reactions than males to aggressive threats because self-protection tends to have higher fitness value for females than males. We examined whether Campbell's theory has more general applicability by considering whether human females respond with greater self-protectiveness than males to other threats beyond aggression. We searched the literature for physiological, behavioral, and emotional responses to major physical and social threats, and found consistent support for females’ responding with greater self-protectiveness than males. Females mount stronger immune responses to many pathogens; experience a lower threshold to detect, and lesser tolerance of, pain; awaken more frequently at night; express greater concern about physically dangerous stimuli; exert more effort to avoid social conflicts; exhibit a personality style more focused on life's dangers; react to threats with greater fear, disgust and sadness; and develop more threat-based clinical conditions than males. Our findings suggest that in relation to threat human females have relatively heightened protective reactions compared to males. The pervasiveness of this result across multiple domains suggests that general mechanisms might exist underlying females’ unique adaptations. An understanding of such processes would enhance knowledge of female health and well-being.

Gender Muddle: Reply to Dembroff

Robin Dembroff’s “Escaping the natural attitude about gender” replies to my “Are women adult human females?”. This paper responds to Dembroff’s many criticisms of my arguments, as well as to the charge that “Are women...?” “fundamentally is an unscholarly attempt to vindicate a political slogan that is currently being used to undermine civic rights and respect for trans persons”. I argue that Dembroff’s criticisms fail without exception, and explain why the claims about my motives are baseless.

Deflating Byrne’s “Are Women Adult Human Females?”

The primary aim of this paper is to show that Alex Byrne’s arguments in “Are Women Adult Human Females?” provide no reason to doubt the truth of the proposition that trans women are women. Byrne’s conclusion is that women are adult human females. However, it is safe to say that much of the interest in his article is driven by the assumption that it is a short step from that conclusion to the further conclusion that trans women are not women. If Byrne is understood to be defending that further conclusion, however, then some of his arguments are dialectically ineffective. The others commit an evidential fallacy or rest on a false premise.

Then, we were wolves, again: the mutable lycanthropy mythos and its challenge to anthropocentrism and androcentric thought

In literature and film, werewolves have gone through an incredibly varied series of portrayals, but, throughout all of their changes (cycling largely between being antagonists and protagonists), werewolves have always interacted with the essentialist concept of the human-animal binary. Mutable at their core, werewolves reflect the people, places, and times of their various manifestations; the werewolf is whatever we need it to be. The fact that werewolves are inherently liminal creatures means that, for the purposes of my thesis' discussion, werewolves can serve as a tool for addressing preconceived notions of human exceptionalism (i.e., anthropocentrism). I question the assumptions of boundaries and socalled human traits with a story about embracing the uncertainty that our classifications and labels seek to efface. Simultaneously, I draw attention to female werewolves to level a concurrent challenge against patriarchal scripts that denigrate the association of human females with non-human animals. Just as many historical portrayals of werewolves reinforce the negative connotations of a woman-animal alignment, so too do contemporary representations of female werewolves become subject to portrayals that reinforce patriarchal values, rather than challenge them. Therefore, my focus is two-fold: to present an alternative narrative (in the form of a theory piece married to a novel) that draws attention to the artificial nature of both anthropocentrism and androcentrism. These two ways of thinking—that humans are inherently more important than animals and that the perspectives of male humans, in particular, trump all other points of view—are inextricably linked in their ideological othering of alternative experiences of being. The female werewolf, an embodiment of both inferior entities, is a well-suited symbol to decentralize dominant patriarchal narratives. Presented herein is my theory piece and the first fifteen chapters of my novel, Then, We Were Wolves, Again. It is a story about a woman who becomes the wolf she was all along and a man who undergoes a transformation but does not change. As a human, the protagonist, Harley, drifted through life like a lone wolf, but now, as an actual werewolf, she struggles to reconcile her instinctual need for her pack with her growing sense of disenchantment with her fellow lycanthropes. Indoctrinated by their leader, Arden, they're convinced of their sovereignty as a superior species to humans, but this new werewolf picks away at the cracks of hypocrisy, revealing the same species-centric thinking the wolves claim to transcend.

Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor against Pathophysiological Decline of Lung Function

The oxidant/antioxidant imbalance plays a pivotal role in the lung. Uric acid (UA), an endogenous antioxidant, is highly present in lung tissue, however, its impact on lung function under pathophysiological conditions remains unknown. In this work, pharmacological and genetic inhibition of UA metabolism in experimental mouse models of acute and chronic obstructive pulmonary disease (COPD) revealed that increased plasma UA levels improved emphysematous phenotype and lung dysfunction in accordance with reduced oxidative stress specifically in female but not in male mice, despite no impact of plasma UA induction on the pulmonary phenotypes in nondiseased mice. In vitro experiments determined that UA significantly suppressed hydrogen peroxide (H2O2)-induced oxidative stress in female donor-derived primary human bronchial epithelial (NHBE) cells in the absence of estrogen, implying that the benefit of UA is limited to the female airway in postmenopausal conditions. Consistently, our clinical observational analyses confirmed that higher blood UA levels, as well as the SLC2A9/GLUT9 rs11722228 T/T genotype, were associated with higher lung function in elderly human females. Together, our findings provide the first unique evidence that higher blood UA is a protective factor against the pathological decline of lung function in female mice, and possibly against aging-associated physiological decline in human females.

rape

Only the rape of citizens was taken seriously by law. Sexual assaults on non-citizens were lesser matters. Rape of enslaved persons, a daily reality, was a crime only if committed by someone other than their owner. Rape of citizen males damaged their reputations; rape of citizen females could render them ineligible for marriage. Ancient myth features almost countless stories of rape, usually of human females by divine males. These tales were common subjects in ancient art and literature. Overwhelmingly, the victims are unmarried girls, who may suffer brutal treatment afterward and frequently bear miraculous offspring, some of whom establish cities (e.g., Romulus and Remus). Rape by human men is rarer in myth; rape of a wife causes massive militarized response (e.g., Helen of Troy, Lucretia). War-rape and post-war rape were standard practice around the Mediterranean.