major intrinsic proteins
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2018 ◽  
Author(s):  
Abul Kalam Azad ◽  
Jahed Ahmed ◽  
Al Hakim ◽  
Md. Mahbub Hasan ◽  
Md. Asraful Alum ◽  
...  

ABSTRACTMajor intrinsic proteins (MIPs), commonly known as aquaporins, facilitate the membrane diffusion of water and some other non- polar solutes. MIPs might be involved in host-pathogen interactions. Herein, we identified 17, 24, 27, 19, 19, and 22 full-length MIPs, respectively, in the genomes of six Phytophthora species, P. infestans, P. parasitica, P. sojae, P. ramorum, P. capsici, and P. cinnamomi. These Phytophthora species are devastating plant pathogens and members of oomycetes, a distinct lineage of fungus-like eukaryotic microbes. Phylogenetic analysis showed that the Phytophthora MIPs (PMIPs) formed a completely distinct clade from their counterparts in other taxa and were clustered into nine subgroups. Sequence and structural properties indicated that the primary selectivity-related constrictions, including aromatic arginine (ar/R) selectivity filter and Froger’s positions in PMIPs were distinct from those in other taxa. The substitutions in the conserved Asn-Pro-Ala motifs in loops B and E of many PMIPs were also divergent from those in plants. We further deciphered group-specific consensus sequences/motifs in different loops and transmembrane helices of PMIPs, which were distinct from those in plants, animals, and microbes. The data collectively supported the notion that PMIPs might have novel functions.


2018 ◽  
Vol 107 ◽  
pp. 2630-2642 ◽  
Author(s):  
Abul Kalam Azad ◽  
Jahed Ahmed ◽  
Md. Asraful Alum ◽  
Md. Mahbub Hasan ◽  
Takahiro Ishikawa ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157735 ◽  
Author(s):  
Abul Kalam Azad ◽  
Jahed Ahmed ◽  
Md. Asraful Alum ◽  
Md. Mahbub Hasan ◽  
Takahiro Ishikawa ◽  
...  

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0138786 ◽  
Author(s):  
Cristina de Paula Santos Martins ◽  
Andresa Muniz Pedrosa ◽  
Dongliang Du ◽  
Luana Pereira Gonçalves ◽  
Qibin Yu ◽  
...  

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