Rhenium Carbonyl Complexes Conjugated with Methylated Triphenylphosphonium Cations as Sensitive Mitochondria Trackers for X-Ray Fluorescence Imaging

<div>Synchrotron Radiation X-ray Fluorescence (SXRF) imaging is a powerful technique for the visualization of metal complexes in biological systems. However, due to the lack of an endogenous elemental signature for mitochondria, probes for the localization of this organelle are required for colocalization studies. In this work, we designed and synthesized rhenium pyta tricarbonyl complexes conjugated to methylated triphenylphosphonium TP*P+ cations as multimodal probes for the visualization of mitochondria, suitable for fluorescence and SXRF imaging and quantification. Accumulation of the methylated triphenylphosphonium TP*P+-based conjugates in cells was observed in fixed A549 cells, and the amount of mitochondrial uptake was linked to the lipophilicity of the TPP+ vector. Our work highlights a convenient rhenium-based multimodal mitochondrial-targeted probe compatible with SXRF nano-imaging.</div>

Rhenium Carbonyl Complexes Conjugated with Methylated Triphenylphosphonium Cations as Sensitive Mitochondria Trackers for X-Ray Fluorescence Imaging

<div>Synchrotron Radiation X-ray Fluorescence (SXRF) imaging is a powerful technique for the visualization of metal complexes in biological systems. However, due to the lack of an endogenous elemental signature for mitochondria, probes for the localization of this organelle are required for colocalization studies. In this work, we designed and synthesized rhenium pyta tricarbonyl complexes conjugated to methylated triphenylphosphonium TP*P+ cations as multimodal probes for the visualization of mitochondria, suitable for fluorescence and SXRF imaging and quantification. Accumulation of the methylated triphenylphosphonium TP*P+-based conjugates in cells was observed in fixed A549 cells, and the amount of mitochondrial uptake was linked to the lipophilicity of the TPP+ vector. Our work highlights a convenient rhenium-based multimodal mitochondrial-targeted probe compatible with SXRF nano-imaging.</div>

Rhenium carbonyl complexes bearing methylated triphenylphosphonium cations as antibody-free mitochondria trackers for X-ray fluorescence imaging

Synchrotron Radiation X-ray Fluorescence (SXRF) imaging is a powerful technique for the visualization of metal complexes in biological systems. However, due to the lack of an endogenous elemental signature for...

Correction: A new phosphotungstate-supported rhenium carbonyl derivative: synthesis, characterization and catalytic selective oxidation of thiophenes

Correction for ‘A new phosphotungstate-supported rhenium carbonyl derivative: synthesis, characterization and catalytic selective oxidation of thiophenes’ by Jingkun Lu et al., CrystEngComm, 2019, 21, 7322–7328.

A new phosphotungstate-supported rhenium carbonyl derivative: synthesis, characterization and catalytic selective oxidation of thiophenes

We synthesized a new phosphotungstate-supported rhenium carbonyl derivative, [N(CH3)4]6H4[P2W17O62{Re(CO)3}2]·25H2O, existing the first {Re2} fragment. Moreover, it also exhibits high efficiency for the selective oxidation of thiophenes.

Synthesis, characterization and catalytic epoxidation properties of a new tellurotungstate(iv)-supported rhenium carbonyl derivative

We synthesized a new tellurotungstate(iv)-supported rhenium carbonyl derivative, Na2H2[(CH3)4N]6[Te2W20O70{Re(CO)3}2]·20H2O (1). Additionally, compound 1 showed excellent catalytic activity in the selective epoxidation of alkenes under comparatively mild reaction conditions.