Prevalence of overweight among Dutch primary school children living in JOGG and non-JOGG areas

Background One of the most influential integrated approaches towards reducing childhood obesity is EPODE, a program that has been translated to over 20 different countries worldwide. Aim The goal of this study was to explore how JOGG–the Dutch EPODE adaptation–might reduce overweight prevalence among children. Methods To compare whether overweight prevalence was different in JOGG areas vs. non-JOGG areas, in long-term JOGG areas vs. short-term JOGG areas, and in low SES JOGG areas vs. middle/high SES JOGG areas, secondary anthropometric and personal data of 209,565 Dutch children were mapped onto publicly available JOGG data. Results Findings showed that overweight prevalence decreased from 25.17% to 16.08% in JOGG-areas, and from 32.31% to 18.43% in long-term JOGG areas. However, when taking into account SES, the decrease in prevalence was mainly visible in low SES long-term JOGG areas. Conclusion JOGG appeared to be successful in targeting areas where overweight was most prevalent. Low SES areas that had implemented JOGG for a longer period of time, i.e., six years, appeared to be successful in decreasing overweight prevalence.

Islandscapes and Sustainable Creative Tourism: A Conceptual Framework and Guidelines for Best Practices

As strategies for the development of creative tourism multiply in contexts ranging from global cities to small communities, the need for a clearer conceptual framework, capable of better differentiating existing approaches, has become more evident. Building upon existing knowledge on cultural and creative tourism, and on a prior review of the literature on creative tourism on islands, this paper proposes a typology of creative tourism initiatives, and after examining this new categorization, develops the concept of sustainable creative tourism. Through highlighting the need for creative tourism developers, policymakers, and practitioners to deepen their engagement with more holistic and integrated approaches oriented towards sustainable development in all its dimensions (economic, environmental, social, and cultural), the authors systematize a set of international principles and policy recommendations meant to promote sustainable creative tourism development strategies, duly adjusted to different places and realities, with an emphasis on vulnerable islandscapes.

Determining the architecture of nuclear ring of Xenopus laevis nuclear pore complex using integrated approaches

The nuclear pore complexes (NPCs) are large protein assemblies as a physical gate to regulate nucleocytoplasmic transport. Here, using integrated approaches including cryo-electron microscopy, hybrid homology modeling and cell experiment, we determined the architecture of the nuclear ring (NR) from Xenopus laevis oocytes NPC at subnanometer resolution. In addition to the improvement of the Y complex model, eight copies of Nup205 and ELYS were assigned in NR. Nup205 connects the inner and outer Y complexes and contributes to the assembly and stability of the NR. By interacting with both the inner Nup160 and the nuclear envelope (NE), the N-terminal β-propeller and α-solenoid domains of ELYS were found to be essential for accurate assembly of the NPC on the NE.