We prove that the presence of a diagonal assortative degree correlation, even if small, has the effect of dramatically lowering the epidemic threshold of large scale-free networks. The correlation matrix considered is
P
h
|
k
=
1
−
r
P
h
k
U
+
r
δ
h
k
, where
P
U
is uncorrelated and
r
(the Newman assortativity coefficient) can be very small. The effect is uniform in the scale exponent
γ
if the network size is measured by the largest degree
n
. We also prove that it is possible to construct, via the Porto–Weber method, correlation matrices which have the same
k
n
n
as the
P
h
|
k
above, but very different elements and spectra, and thus lead to different epidemic diffusion and threshold. Moreover, we study a subset of the admissible transformations of the form
P
h
|
k
⟶
P
h
|
k
+
Φ
h
,
k
with
Φ
h
,
k
depending on a parameter which leaves
k
n
n
invariant. Such transformations affect in general the epidemic threshold. We find, however, that this does not happen when they act between networks with constant
k
n
n
, i.e., networks in which the average neighbor degree is independent from the degree itself (a wider class than that of strictly uncorrelated networks).