Subcortical Volume Changes in Early Menopausal Women and Correlation With Neuropsychological Tests

Background: The aging process and declining estradiol levels are two important factors that cause structural brain alterations. Many prior studies have investigated these two elements and revealed controversial results in menopausal women. Here, a cross-sectional study was designed to individually evaluate estradiol-related structural changes in the brain.Methods: A total of 45 early menopausal women and 54 age-matched premenopausal controls were enrolled and subjected to magnetic resonance imaging (MRI) scans, blood biochemistry tests, and neuropsychological tests. MRI structural images were analyzed using FreeSurfer to detect changes in subcortical and cortical volumes as well as cortical thickness. Finally, structural brain data as well as clinical and neuropsychological data were used for Pearson’s correlation analyses to individually determine estradiol-related structural and functional changes in the brains of early menopausal women.Results: Compared with the premenopausal controls, the early menopausal women showed significant subcortical volumetric loss in the left amygdala and right amygdala, higher serum follicle-stimulating hormone (FSH) levels, more recognizable climacteric and depressive symptoms, decreased quality of sleep, and decreased working memory and executive functions. Simultaneously, FSH levels were related to lower working memory accuracy and longer working memory reaction time. Decreased subcortical volume in the bilateral amygdala was also related to lower working memory accuracy and longer executive reaction time in early menopausal women.Conclusion: The data suggest that estradiol deficiency in early menopausal women can lead to subcortical volume and functional brain changes, which may contribute to further understanding the neurobiological role of declined estradiol levels in early menopausal women.

Memory Accuracy After 20 Years for Interviews About Child Maltreatment

When adults allege childhood victimization, their long-term memory comes under scrutiny. This scrutiny can extend to the adults’ memory of childhood interviews. The concerns raise important theoretical and applied issues regarding memory for long-past discussions of child maltreatment and trauma. In this longitudinal study, 104 adults, who as children (ages 3–15 years) were interviewed in child maltreatment investigations (Time 1), were questioned 20 years later (Time 2) about the Time 1 interviews. Verbatim documentation from Time 1 permitted scoring of memory accuracy. A subset of the participants (36%) reported no memory for the Time 1 interviews. Of the 64% who remembered being interviewed at Time 1, those who had been adolescents at Time 1 remembered the forensic interview discussion about abuse incidents better than discussion about general psychological issues. Adult trauma symptoms were associated with more accurate memory for interview content that directly concerned abuse experiences but not for non–abuse-specific information. Findings indicate that the veracity of adults’ long-term memory for clinical/forensic conversations about childhood maltreatment depends on age at interview, interview content, and traumatization factors. Implications are discussed.

Long Retention Intervals Impair the Confidence-Accuracy Relationship for Eyewitness Recall

A growing body of research suggests that confidence judgements can provide a useful indicator of memory accuracy under some conditions. One factor known to affect eyewitness accuracy, yet rarely examined in the confidence-accuracy literature, is retention interval. Using calibration analyses, we investigated how retention interval affects the confidence-accuracy relationship for eyewitness recall. In total, 611 adults watched a mock crime video and completed a cued-recall test either immediately, after 1 week, or after 1 month. Long (1 month) delays led to lower memory accuracy, lower confidence judgements, and impaired the confidence-accuracy relationship compared to shorter (immediate and 1 week) delays. Long-delay participants who reported very high levels of confidence tended to be over-confident in the accuracy of their memories compared to other participants. Self-rated memory ability, however, did not predict eyewitness confidence or the confidence-accuracy relationship. We discuss the findings in relation to cue-utilization theory and a retrieval-fluency account.

EXPRESS: Drawing Individual Images Benefits Recognition Accuracy in the DRM Paradigm

We examined the effects of drawing on correct and false recognition within the Deese/Roediger-McDermott (DRM) false memory paradigm. In Experiment 1, we compared drawing of a word’s referent using either a standard black pencil or colored pencils relative to a read-only control group. Relative to reading, drawing in either black or colored pencil similarly boosted correct recognition and reduced false recognition. Signal-detection analyses indicated that drawing reduced the amount of encoded memory information for critical lures and increased monitoring, indicating that both processes contributed to the false recognition reduction. Experiment 2 compared drawing of individual images of DRM list items relative to drawing integrated images using sets of DRM list items. False recognition was lower for drawing of individual images relative to integrated images—a pattern that reflected a decrease in encoded memory information but not monitoring. Therefore, drawing individual images improves memory accuracy in the DRM paradigm relative to a standard read-control task and an integrated drawing task, which we argue is due to the recruitment of item-specific processing.

Intact context memory performance in adults with autism spectrum disorder

Research on memory in autism spectrum disorder (ASD) finds increased difficulty encoding contextual associations in episodic memory and suggests executive dysfunction (e.g., selective attention, cognitive flexibility) and deficient metacognitive monitoring as potential contributing factors. Findings from our lab suggest that age-related impairments in selective attention contribute to those in context memory accuracy and older adults tended to show dependence in context memory accuracy between relevant and irrelevant context details (i.e., hyper-binding). Using an aging framework, we tested the effects of selective attention on context memory in a sample of 23 adults with ASD and 23 typically developed adults. Participants studied grayscale objects flanked by two types of contexts (color, scene) on opposing sides and were told to attend to only one object-context relationship, ignoring the other context. At test, participants made object and context recognition decisions and judgment of confidence decisions allowing for an evaluation of context memory performance, hyper-binding, and metacognitive performance for context judgments in a single task. Results showed that adults with ASD performed similarly to typically developed adults on all measures. These findings suggest that context memory performance is not always disrupted in adults with ASD, even when demands on selective attention are high. We discuss the need for continued research to evaluate episodic memory in a wider variety of adults with ASD.