The Spatiotemporal Coupling: Regional Energy Failure and Aberrant Proteins in Neurodegenerative Diseases

The spatial and temporal coordination of each element is a pivotal characteristic of systems, and the central nervous system (CNS) is not an exception. Glial elements and the vascular interface have been considered more recently, together with the extracellular matrix and the immune system. However, the knowledge of the single-element configuration is not sufficient to predict physiological or pathological long-lasting changes. Ionic currents, complex molecular cascades, genomic rearrangement, and the regional energy demand can be different even in neighboring cells of the same phenotype, and their differential expression could explain the region-specific progression of the most studied neurodegenerative diseases. We here reviewed the main nodes and edges of the system, which could be studied to develop a comprehensive knowledge of CNS plasticity from the neurovascular unit to the synaptic cleft. The future goal is to redefine the modeling of synaptic plasticity and achieve a better understanding of neurological diseases, pointing out cellular, subcellular, and molecular components that couple in specific neuroanatomical and functional regions.

Modeling transition paths towards decentralized regional energy autonomy: the role of legislation, technology adoption, and resource availability

Decentralized energy systems are increasingly seen as a key factor for a transition towards a low-carbon, renewable energy based society. Within the transition process, regional demand and supply of renewable energy carriers have to be aligned, while considering the environmental conditions of the region. This paper focuses on the energy demand from buildings, which makes up 35% of the total energy demand. It presents an approach for aligning the regional supply potential of renewable energy carriers with the dynamics of regional energy demand from buildings. The approach consists of two components. First, a dynamic model simulates regional energy demand from buildings taking into consideration envelope renovation, legislative standards, and adoption of heating technologies. Second, the regional supply is estimated based on the technical maximum possible, taking into consideration competing uses and spatial limitations. We show a first application in the case of the energy region Weiz-Gleisdorf, Austria, which aims to achieve CO2 neutrality and energy self-sufficiency by the year 2050. Our results show that in the year 2050 (i) energy demand from buildings will decrease by 40–55%, depending on envelope renovation rates and legislative standards; (ii) demand for the different renewable energy carriers will be determined by the choice of heating technology; (iii) the demand for wood could be met from regional forest resources, as long as there are no additional demands for other purposes; (iv) the demand for biomass for district heating would require 5–10% of the agricultural area to be used for the production of energy plants rather than food; and (v) in contrast to other forms of energy, the demand for electricity will remain constant or increase slightly over time. This demand could only be regionally met if significant areas of façades or gardens are used for photovoltaic electricity production in addition to roofs. Overall we identified several issues related to spatial planning and a need for further research regarding the transition towards decentralized energy systems. First, if biomass for central district heating systems is to come from regional production, areas should be allocated for cultivating energy crops used specifically to produce fuel. Second, if wood is used for district heating purposes, the extent to which the import of wood from neighboring regions would be a useful ecological solution must be evaluated; this would involve extending regional energy planning beyond the typical jurisdictional boundaries while considering ecological issues.