Mechanisms and substances involved in clastic activity of root resorptions – literature review

Aim: to research through literature review, the mechanisms involved in the establishment of root resorptions. Mediators such as interleukins, prostaglandins, nitric oxide and systemic calcium available were studied in this review. Methods: On line searches were accomplished by scrutinizing the database available from PUBMED Central, BVS/BIREME. Web of Science, Science Direct, Periodic Portal from CAPES, as well as The Cochrane Library and PROSPERO were also used. The inclusion criteria were articles that described osteoclastic activity involving the hard dental tissues (cement, dentin and enamel). The search acquired 35 articles and excluded other 30. The articles acquired ranged from 1976 up to 2017. Results: the results showed that the combination of the immunologic mediators researched above will be the determinant factors on the establishment of root resorptions. Conclusions: Prostaglandins, Interleukins as well as the systemic calcium available are some of the most important factors for the establishment of root resorptions. Their final outcome, however, depends directly on the quality of injury inflicted over the group of teeth, or single tooth, involved.

New scaled algorithm for non-linear conjugate gradients in unconstrained optimization

<p>A new scaled conjugate gradient (SCG) method is proposed throughout this paper, the SCG technique may be a special important generalization conjugate gradient (CG) method, and it is an efficient numerical method for solving nonlinear large scale unconstrained optimization. As a result, we proposed the new SCG method with a strong Wolfe condition (SWC) line search is proposed. The proposed technique's descent property, as well as its global convergence property, are satisfied without the use of any line searches under some suitable assumptions. The proposed technique's efficiency and feasibility are backed up by numerical experiments comparing them to traditional CG techniques.</p>

Drug Candidates for Covid-19 Treatment in Brazil

Background: COVID-19 has emerged worldwide in less than 6 months, leaving millions of deaths behind. While scientist search for new drugs, an old arsenal has been proposed as a form of treatment. Objective: This article was designed as a literature review, scrutinizing antiparasitic chloroquine, ivermectin, nitazoxanide; and also glucocorticoids, as candidates to be applied in patients with COVID-19 in some Brazilian hospitals. Methodology: clinical evidence of COVID-infected patients and literature consultation have been accomplished for the construction of this article. On line searches and gray literature have also been consulted, whose database include PUBMED Central, BVS/BIREME, Web of Science, Science Direct, Higher Level Personnel Improvement Coordinator (CAPES), Periodic Door (Portal de Periódicos da CAPES, The Cochrane Library and PROSPERO). Results: chloroquine, ivermectin and nitazoxanide do present antiviral characteristics to support their usage in phase 1 of COVID-19 symptoms. Glucocorticoids, especially methylprednisolone and dexamethasone, seem to be efficient in patients with pulmonary symptoms, such as those present in phase 2B and 3 of the disease. Conclusion: After analyzing the literature, antiparasitic agents constitute a promising approach for patients with COVID-19. However, their usage seems to be efficient in the very beginning of the symptoms. Methylprednisolone and dexamethasone are best indicated for hospitalized patients with pulmonary commitment.

Antimalarial chloroquine indicated for viral infections: myth ou hope?

Aim: this article describes the use of chloroquine as an antimalarial agent with potential antivirotic indications for COVID-19 infections. Methods: On line searches and gray literature have been used in the construction of this articles, whose database include PUBMED Central, BVS/BIREME, Web of Science, Science Direct, Higher Level Personnel Improvement Coordinator (CAPES), Periodic Door (Portal de Periódicos da CAPES, The Cochrane Library and PROSPERO). Results: chloroquine and hydroxychloroquine has shown appropriate clinical reports when associated with the antibiotic Azithromycin. It has been authorized for the clinical treatment of grave acute forms of COVID infections by countries like Brazil and USA. Conclusions: Chloroquine seems to have potential antivirotic properties that may be useful in the treatment of the grave acute forms of COVID-19 associated with Azithromycin. Nevertheless, Its indication must include ECG monitoring due to the risk of cardiac QT prolongation able to cause sudden deaths.

Apice closure in Pulp Revascularization Therapy. Case report and literature review

Background: Endodontic Regenerative Procedures, especially pulp revascularization therapy, have become a real option for the treatment for immature permanent teeth with open apices. This sort of approach has saved many teeth that otherwise would have been extracted. The technique is simple and effective, and can be accomplished by any odontologist. Objective: This article aimed to make a literature review to give support for a case report of an Endodontic Regenerative Procedure of a twelve-year-old male patient with immature open apice of tooth 21. Methodology: Articles were researched concerning pulp revascularization to reach root end formation. On line searches were accomplished, whose database include BVS/BIREME, Web of Science, PUBMED Central, Science Direct, Higher Level Personnel Improvement Coordinator (CAPES), The Cochrane Library, and PROSPERO). Results: the articles researched showed that Endodontic Regenerative Procedures are efficient in stimulating root end formation. The case report described matched the results offered by the articles, showing an immature open apice tooth that had its root end completely formed after pulp revascularization therapy. Conclusion: Pulp revascularization therapy is an efficient and practical treatment for immature teeth with open apices.

The role of antiparasitc drugs and steroids in Covid-19 treatment

Background: COVID-19 has emerged as a pandemic that spread throughout the world in less than 6 months, leaving hundred thousand deaths behind. Surprisingly, old drug arsenal has now been applied as an option of treatment. Objective: The aim of this article was to accomplish a literature review concerning the antiparasitic chloroquine, ivermectin, nitazoxanide; as well as glucocorticoids as possible therapeutic agents to be applied in patients with COVID-19 in Brazilian hospitals. Methodology: clinical evidence of COVID-infected patients and literature consultation have been used for the construction of this article. On line searches and gray literature have also been consulted, whose database include PUBMED Central, BVS/BIREME, Web of Science, Science Direct, Higher Level Personnel Improvement Coordinator (CAPES), Periodic Door (Portal de Periódicos da CAPES, The Cochrane Library and PROSPERO). Results: chloroquine, ivermectin and nitazoxanide present antiviral characteristics to support their usage in phase 1 of COVID-19 symptoms. Glucocorticoids such as methylprednisolone and dexamethasone seem to be more efficient in patients with pulmonary symptoms such as those in phase 2B and 3. Conclusion: According to the articles raised in this review, antiparasitic agents are promising for patients with COVID-19 in the very beginning of the symptoms. Methylprednisolone and dexamethasone are best indicated for hospitalized patients with pulmonary commitment.

Convergent Inexact Penalty Decomposition Methods for Cardinality-Constrained Problems

In this manuscript, we consider the problem of minimizing a smooth function with cardinality constraint, i.e., the constraint requiring that the "Equation missing"-norm of the vector of variables cannot exceed a given threshold value. A well-known approach of the literature is represented by the class of penalty decomposition methods, where a sequence of penalty subproblems, depending on the original variables and new variables, are inexactly solved by a two-block decomposition method. The inner iterates of the decomposition method require to perform exact minimizations with respect to the two blocks of variables. The computation of the global minimum with respect to the original variables may be prohibitive in the case of nonconvex objective function. In order to overcome this nontrivial issue, we propose a modified penalty decomposition method, where the exact minimizations with respect to the original variables are replaced by suitable line searches along gradient-related directions. We also present a derivative-free penalty decomposition algorithm for black-box optimization. We state convergence results of the proposed methods, and we report the results of preliminary computational experiments.