AN UNUSUAL CASE OF POSTPARTUM CHORIOCARCINOMA WITH VAGINAL METASTASIS AND UTERINE PERFORATION

Gestational trophoblastic disease is a heterogenous group of interrelated lesions that arise from abnormal proliferation of placental 1 trophoblasts . Choriocarcinoma differs from any type of villous trophoblast and is the most aggressive GTN and is highly chemosensitive. When a patient reports with irregular bleeding during her postpartum or postabortion, pregnancy related causes should be ruled out. We describe a patient who presented to us after a term pregnancy and was diagnosed to have stage III choriocarcinoma.

Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature

Ovarian malignant germ cell tumors (OMGCT) represent less than 10% of all ovarian tumors. Dysgerminoma is the most common malignant primitive germ cell tumor in young women, known for its curability and low propensity to invade and metastasize when diagnosed early. Herein, we report an unusual type of ovarian dysgerminoma (OD) metastasis with a brief review of the literature, lacking similar reported cases. To our knowledge, although there are several case reports of dysgerminoma metastases with variable anatomic location and presentation, vaginal metastasis has not been previously described. The local or systemic relapse together with local and distant metastasis is considered as an independent predictor of poor survival in patients with OD. In light of the absence of mutations status, our patient successfully responded to therapy. Currently, the patient remains in clinical remission. A specific follow-up plan is ongoing knowing that ovarian dysgerminomas tend to recur most often in the first 2–3 years after treatment.

Synchronous Vaginal Metastasis in Patient with Clear-Cell RCC. A Case Report and Review of the Literature

Background: Vaginal metastasis, despite being rare, are more common than primary tumors and as presentation of the disease is extremely rare. At the time of diagnosis metastasis by hematogenous or lymphatic spread in 20-30% of patients. Case presentation: 68 years old female patient that debuted with haematuria. In the extension study we can objectify a left renal mass treated by laparoscopic radical nephrectomy. During admission the patient presented and episode of metrorragia. A lesion was found in the lower thrid of the vagina, which was biopsed, resulting a vaginal metastasis of clear cell carcinoma. The patient presented a favorable evolution being discharged four days after de surgical intervention. The subsequent extension study revealed progression of the underlying disease with mediastinal nodes and bone metastases.

Vaginal metastasis in solid tumours: our four cases and review of the literature

Background Vaginal metastasis should be kept in mind when evaluating the staging tests of all cancers, especially endometrial cancer. Case presentation We present four patients with vaginal recurrence who recently applied to our clinic. Three cases were of endometrial cancer and one case of rectal cancer. All patients presented with vaginal bleeding. Conclusion Standard treatment for vaginal metastasis has not yet been established. Therapeutic options for vaginal metastasis—separately or in combination—are surgical resection, radiotherapy, and chemotherapy.

Metastatic solitary vaginal nodule from a primary rectal tumor.

Introduction: An isolated vaginal metastasis from a primary colorectal adenocarcinoma is extremely rare. Based on meticulous literature review, only seven cases were reported from 1956 – 2013. Case Presentation: We present a case of a 52-year-old female patient diagnosed with rectal adenocarcinoma, underwent low anterior resection of the primary tumor, and then was found to have an asymptomatic isolated vaginal metastasis that was completely excised. Conclusion: Isolated vaginal metastatic disease is one of the rarest entities in surgical oncology with only limited cases being reported in the literature. A diagnosis can be challenging if the metastatic lesion is small and asymptomatic even with the most advanced radiological assessment tools. A meticulous examination should be done pre-operatively in order to rule out such diagnosis.