Spindle cell oncocytoma, a misdiagnosed rare entity of the pituitary – A case report with review of literature and special emphasis on the morphological differentials

Spindle cell oncocytoma (SCO) of the pituitary is a rare tumor of the adenohypophysis occurring in the sellar/suprasellar region. This tumor has been recognized as a distinct entity by the WHO Classification of CNS tumor in 2007. Spindle cell oncocytoma of the pituitary gland accounts for 0.1–0.4% of all sellar region tumors and is predominantly seen in the older adult population. This rare entity simulates clinical and radiological features of pituitary adenoma and is often misdiagnosed. Though WHO grade 1, the tumor can recur and have invasive properties. Herein, we report a 61-year-old woman with panhypopituitarism and temporal field cut, clinically and radiologically diagnosed as pituitary macroadenoma, while the histomorphological and immunohistochemistry features helped in arriving at a diagnosis of Spindle Cell Oncocytoma. The clinicopathological, histomorphological, immunohistochemical, and molecular properties of the tumor are further discussed.

Transcription for a synth keyboard (the case study of the work of A. Artemiev, V.Martynov, Yu. Bogdanov - the disc “Metamorphoses”)

The author analyzes the experience of transcription of the compositions of J. Bull, C. Monteverdi, J. Bach, C. Debussy and S. Prokofiev for a synth keyboard Synthi 100 done by the Russian composers A. Artemiev, V. Martynov, Yu. Bogdanov in 1980, and released on the disc “Metamorphoses”. The author also considers the composers’ range of artistic tasks and sound solutions and the variants of work with the texture of the original compositions. The electronic interpretations, contained in the “Metamorphoses”, not only demonstrate the examples of transcribing the original text for a synth keyboard, but also illustrate the 4 criteria of electronic music formulated by K. Stockhausen: unified temporal structuring (a common temporal field), the disintegration of sound, a multidimensional spatial composition, and the equality of the tone and the noise.  In spite of the fact that the transcription of classical music pieces for a synth keyboard was carried out by the Russian composers several decades ago, this experience hasn’t been studied yet. Probably, it is explained by the fact that the analysis and description of electronic music using traditional means is complicated, since the material under study is not noted: all transformations carried out by the interpreter are fixed only in the audiorecord.  The analysis of transcriptions is complicated by the fact that electronic instruments are regularly upgraded and transformed, and therefore their artistic capacity is increased. The change of instruments caused the transformation of approach to music art. The article analyzes the transformation of the author’s text, the transformation of a piano texture into the electronic score, and the role of the arranger as a co-author of the composition.  

High-Fidelity Control of Spin Ensemble Dynamics via Artificial Intelligence: From Quantum Computing to Imaging

High-fidelity control of spin ensemble dynamics is essential to many fields, spanning from quantum computing to optical, coherent, and nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI). However, attaining robust and high-fidelity quantum spin operations remains an unmet challenge. Using a combination of an evolutionary algorithm and artificial intelligence, we designed time-optimal, radio frequency (RF) pulses with tunable spatial or temporal field inhomogeneity compensation and fidelity for unitary operations up to 0.9999. As a benchmark, we constructed a spin entanglement operator and a programmable quantum state creator for a weakly-coupled two-spin-1/2 system. We achieved high-fidelity transformations under multiple inhomogeneity sources. The newly designed RF pulses are more robust and less prone to imperfection than the commonly used shapes for basic liquid-state NMR experiments and reduce RF artifacts in MRI. This new strategy will enable the design of efficient quantum computing opera-tors as well as new spectroscopic and imaging techniques.

Integrated structured light architectures

The structural versatility of light underpins an outstanding collection of optical phenomena where both geometrical and topological states of light can dictate how matter will respond or display. Light possesses multiple degrees of freedom such as amplitude, and linear, spin angular, and orbital angular momenta, but the ability to adaptively engineer the spatio-temporal distribution of all these characteristics is primarily curtailed by technologies used to impose any desired structure to light. We demonstrate a laser architecture based on coherent beam combination offering integrated spatio-temporal field control and programmability, thereby presenting unique opportunities for generating light by design to exploit its topology.

Stochastic simulation of the spatio-temporal field of the average daily heat index in Southern Russia

Numerical models of the heat index time series and spatio-temporal fields can be used for a variety of purposes, from the study of the dynamics of heat waves to projections of the influence of future climate on humans. To conduct these studies one must have efficient numerical models that successfully reproduce key features of the real weather processes. In this study, 2 numerical stochastic models of the spatio-temporal non-Gaussian field of the average daily heat index (ADHI) are considered. The field is simulated on an irregular grid determined by the location of weather stations. The first model is based on the method of the inverse distribution function. The second model is constructed using the normalization method. Real data collected at weather stations located in southern Russia are used to both determine the input parameters and to verify the proposed models. It is shown that the first model reproduces the properties of the real field of the ADHI more precisely compared to the second one, but the numerical implementation of the first model is significantly more time consuming. In the future, it is intended to transform the models presented to a numerical model of the conditional spatio-temporal field of the ADHI defined on a dense spatio-temporal grid and to use the model constructed for the stochastic forecasting of the heat index.

Spatial filtration of the field at the interpretation of magnetotelluric data

Using numerical experiments, possibilities of application an analytical model to approximate spatial–temporal field variations on the Earth’s surface at interpretation of magnetotelluric sounding (MTS) data are considered.

Management of arterial injuries in endoscopic endonasal approaches

This is the case of a 76-year-old woman presenting with progressive right vision loss consisting of a right eye temporal field cut and severe visual acuity loss. An MRI was performed showing a suprasellar mass for which she had been referred to our center for an endoscopic endonasal approach. The tumor was found to be densely adherent to adjacent structures, and an ophthalmic artery and A1–A2 junction injury were sustained during resection. The management of intraoperative vascular injuries is described.The video can be found here: https://youtu.be/JJY6nYKTCSg.