A Proposal to Improve the Effectiveness of the Deflection Control Method Provided by Eurocodes for Concrete, Timber, and Composite Slabs

Limited deflection of structural members represents an important requirement to guarantee proper functionality and appearance of building and infrastructures. According to Eurocodes, this requirement is ensured by limiting the maximum deflection of horizontal structural members to a fraction of their span. However, each Eurocode provides different maximum deflection limits, which are independent of the type of superstructures considered. Thus, the respect of these limits may not always guarantee the integrity of certain superstructures. In this paper, the reliability of the Eurocode deflection control methods, in guaranteeing the integrity of the superstructures, is assessed and discussed. First, different types of horizontal member, namely rib and clay (hollow) pot, composite steel–concrete, and timber beam slabs are designed to respect the deflection limit enforced by the Eurocodes. Then, the maximum curvature developed by these members is compared with the ultimate (limit) curvatures of various superstructures (e.g., ceramic and stone tile floorings). The results obtained show that the approach adopted by Eurocode 2 may provide non-conservative results, but also that the rules proposed by Eurocodes 4 and 5, albeit more reliable, do not always guarantee the integrity of the superstructure. Based on these results, an alternative method, based on the curvature control, is proposed and its advantages and limitations critically discussed. This method appears simpler and more reliable than the method currently adopted by the Eurocodes.

Pressure and curvature control of contact inhibition in epithelia growing under spherical confinement

Morphogenesis requires spatiotemporal regulation of cell shape and proliferation, both regulated by biochemical and mechanical cues. In epithelia, this regulation is called contact inhibition, but disentangling biochemical from mechanical cues remains challenging. Here, we show that epithelia growing under confinement accumulate pressure that inhibits proliferation above a threshold value, which depends on the β-catenin pathway. Before inhibition of proliferation, cell aspect ratio abruptly increased upon reaching confluency. This shape transition occurred at low, constant pressure and was mainly controlled by cell density and contractility, correlating with YAP/TAZ pathway inhibition. In our system, epithelia spontaneously buckle: we observed that folding transiently reactivates both the YAP/TAZ pathway and cell proliferation. Altogether, our results support that different mechanical cues part of contact inhibition regulate cell proliferation through different mechanosensing pathways. Proliferation is regulated by sustained, tissue-level pressure through the β-catenin pathway, and by local curvature and pressure changes through the YAP/TAZ pathway.

Retraction: Jang et al. Lateral Handling Improvement with Dynamic Curvature Control for an Independent Rear Wheel Drive EV. World Electr. Veh. J. 2015, 7, 238–243

The journal retracts the article, “Lateral handling improvement with dynamic curvature control for an independent rear wheel drive EV” [...]

Cation Doping Approach for Nanotubular Hydrosilicates Curvature Control and Related Applications

The past two decades have been marked by an increased interest in the synthesis and the properties of geoinspired hydrosilicate nanoscrolls and nanotubes. The present review considers three main representatives of this group: halloysite, imogolite and chrysotile. These hydrosilicates have the ability of spontaneous curling (scrolling) due to a number of crystal structure features, including the size and chemical composition differences between the sheets, (or the void in the gibbsite sheet and SiO2 tetrahedron, in the case of imogolite). Mineral nanoscrolls and nanotubes consist of the most abundant elements, like magnesium, aluminium and silicon, accompanied by uncontrollable amounts of impurities (other elements and phases), which hinder their high technology applications. The development of a synthetic approach makes it possible to not only to overcome the purity issues, but also to enhance the chemical composition of the nanotubular particles by controllable cation doping. The first part of the review covers some principles of the cation doping approach and proposes joint criteria for the semiquantitative prediction of morphological changes that occur. The second part focuses on some doping-related properties and applications, such as morphological control, uptake and release, magnetic and mechanical properties, and catalysis.

Modelling cell guidance and curvature control in evolving biological tissues

Tissue geometry is an important influence on the evolution of many biological tissues. The local curvature of an evolving tissue induces tissue crowding or spreading, which leads to differential tissue growth rates, and to changes in cellular tension, which can influence cell behaviour. Here, we investigate how directed cell motion interacts with curvature control in evolving biological tissues. Directed cell motion is involved in the generation of angled tissue growth and anisotropic tissue material properties, such as tissue fibre orientation. We develop a new cell-based mathematical model of tissue growth that includes both curvature control and cell guidance mechanisms to investigate their interplay. The model is based on conservation principles applied to the density of tissue synthesising cells at or near the tissue’s moving boundary. The resulting mathematical model is a partial differential equation for cell density on a moving boundary, which is solved numerically using a hybrid front-tracking method called the cell-based particle method. The inclusion of directed cell motion allows us to model new types of biological growth, where tangential cell motion is important for the evolution of the interface, or for the generation of anisotropic tissue properties. We illustrate such situations by applying the model to simulate both the resorption and infilling components of the bone remodelling process, and provide user-friendly MATLAB code to implement the algorithms.