Scar Prevention With Prolonged Use of Tissue Adhesive Zipper Immediately After Facial Surgery: A Randomized Controlled Trial

Background Postsurgical scar management significantly affects patient satisfaction. However, reliable skin support options are limited. Objectives The present study aimed to determine the efficacy and safety of using tissue adhesive zippers in postsurgical scar prevention among patients undergoing surgical excision of the face. The primary outcome was a reduction in scar width, which was evaluated 1, 3, 6, and 12 months postoperatively. Scar width at month 12 was considered the final outcome. Methods This was a prospective, randomized, controlled, rater-blinded trial. Sixty-four patients were randomly assigned to two groups (zip group, defined as those using a tissue adhesive zipper for 3 months after surgery, and the control group). Outcomes were evaluated based on scar width and scale at 1, 3, 6, and 12 months postoperatively. Skin irritation was monitored during the first 3 months after surgery. The incidence of hypertrophic scar formation was recorded at a 12-month follow-up. Results Scar width differed significantly between the zip (1.68±0.45 mm) and control groups (2.15±0.64 mm). The scars spread rapidly in the first month after surgery but slowed down and stabilized after 6 months. The scale scores of the zip group were significantly lower than those of the control group. Neither group experienced significant complications. Conclusions Prolonged use of tissue adhesive zippers immediately after surgery reduced scar width and improved scar appearance without obvious side effects.