scholarly journals Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex

2020 ◽  
Vol 56 (57) ◽  
pp. 7885-7888
Author(s):  
Emilie Mathieu ◽  
Anne-Sophie Bernard ◽  
Elodie Quévrain ◽  
Martha Zoumpoulaki ◽  
Sébastien Iriart ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Inflammatory Activity ◽  
Cellular Model ◽  
Intracellular Location ◽  
Anti Inflammatory ◽  
Superoxide Dismutase Mimic

The study of Mn-based superoxide dismutase mimic conjugated with a multimodal Re-probe in a cellular model of oxidative stress revealed that its bioactivity is associated with its accumulation at the mitochondria.

scholarly journals Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides

2020 ◽  
Vol 49 (7) ◽  
pp. 2323-2330
Author(s):  
Emilie Mathieu ◽  
Anne-Sophie Bernard ◽  
H. Y. Vincent Ching ◽  
Andrea Somogyi ◽  
Kadda Medjoubi ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Cell Penetrating Peptides ◽  
Inflammatory Activity ◽  
Intestinal Epithelial ◽  
Cell Penetrating ◽  
Anti Inflammatory ◽  
Superoxide Dismutase Mimic ◽  
Superoxide Dismutase Mimics

A superoxide dismutase mimic was functionalized with three peptides: -R9, -RRWWRRWRR or -Fx-r-Fx-K (MPP). They were studied in intestinal epithelial cells in an inorganic cellular chemistry approach: quantification, distribution and bio-activity.

scholarly journals Anti-inflammatory activity and modulate oxidative stress of Bucida buceras in lipopolysaccharide-stimulated RAW 264.7 macrophages and Carrageenan-induced acute paw edema in rats

2017 ◽  
Vol 11 (12) ◽  
pp. 239-252 ◽  
Author(s):  
B. Iloki Assanga Simon ◽  
M. Lewis Luján Lidianys ◽  
A. Gil-Salido Armida ◽  
L. Lara Espinoza Claudia ◽  
Fernandez Angulo Daniela ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Activity ◽  
Raw 264.7 ◽  
Paw Edema ◽  
Raw 264.7 Macrophages ◽  
Anti Inflammatory

scholarly journals Significant In Vivo Anti-Inflammatory Activity of Pytren4Q-Mn a Superoxide Dismutase 2 (SOD2) Mimetic Scorpiand-Like Mn (II) Complex

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119102 ◽  
Author(s):  
Carolina Serena ◽  
Enrique Calvo ◽  
Mari Paz Clares ◽  
María Luisa Diaz ◽  
Javier U. Chicote ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Superoxide Dismutase 2

scholarly journals In Vivo Evaluation of the Anti-Inflammatory Effect ofPistacia lentiscusFruit Oil and Its Effects on Oxidative Stress

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Sameh Ben Khedir ◽  
Masarra Mzid ◽  
Sana Bardaa ◽  
Dorsaf Moalla ◽  
Zouheir Sahnoun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
New Drugs ◽  
Inflammatory Activity ◽  
Natural Health Products ◽  
Paw Edema ◽  
In Vivo Evaluation ◽  
Anti Inflammatory ◽  
Fruit Oil ◽  
Inflammatory Effect

In order to find new topical anti-inflammatory agents, we had recourse to a medicinal plant. This work was designed to determine the topical anti-inflammatory effect ofPistacia lentiscusfruit oil (PLFO), using carrageenan-induced paw edema rat model, and to evaluate its effects on oxidative stress. The topical anti-inflammatory activity of PLFO was compared to Inflocine® and estimated by measuring the diameter of paw edema, for 5 hours at a 1-hour interval. After that the rats were scarified and the inflamed paw tissue was removed for the exploration of some parameters of oxidative stress and histopathology. PLFO showed a significant anti-inflammatory activity in comparison with the Inflocine. The percentages of edema inhibition were 70% and % 51.5% (p<0.01), respectively, after five hours. The treatment with PLFO and Inflocine led to significant increases (p≤0.05) in the activities of CAT, SOD, and GPX and significant decreases in the MDA level and AOPP activity in the paw tissue after Carr injection, in comparison with the Carr group. Therefore, our findings demonstrate that PLFO might accelerate the development of new drugs which could be used scientifically as a source for natural health products in the treatment of topical inflammation.

scholarly journals Anti-inflammatory activity of 3-cinnamoyltribuloside and its metabolomic analysis in LPS-activated RAW 264.7 cells

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhennan Wang ◽  
Ying Guan ◽  
Rui Yang ◽  
Junjian Li ◽  
Junsong Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Energy Metabolism ◽  
Inflammatory Activity ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
H Nmr ◽  
Stress Energy ◽  
Metabolic Mechanism ◽  
Anti Inflammatory

Abstract Background Inflammation is a response to tissue injuries, which is indispensable and important for human health, but excessive inflammation can potentially cause damage to the host organisms. Camellia nitidissima Chi, one traditional medicinal and edible plant in China, was reported to exhibit anti-inflammation capability. Hence, this study was conducted to isolate the bioactive compounds from the flowers of C. nitidissima Chi and evaluate their anti-inflammatory activity. Methods The phytochemicals from the flowers of C. nitidissima Chi were isolated and purified by silica gel, Sephadex LH-20 gel, C18 reversed silica gel, semi-preparative HPLC, and identified by the spectrum technologies. The anti-inflammatory activity of isolated compounds was evaluated using cultured macrophage RAW 264.7 cells. Whereafter the potential metabolic mechanism of the anti-inflammatory activity of the bioactive compound was investigated by a 1H-NMR based metabolomics approach. The metabolites in 1H-NMR spectra were identified by querying the Human Metabolome Database and Madison Metabolomics Consortium Database online. And the multivariate statistical analysis was performed to evaluate the variability of metabolites among samples and between sample classes. Results The compound isolated from the flowers of C. nitidissima Chi was identified as 3-cinnamoyltribuloside (3-CT). 3-CT could inhibit the NO production and the mRNA expression of iNOS involved in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Moreover, 3-CT could inhibit the expression of a series of inflammatory cytokines, including TNF-α, IL-1β, and IL-6, both at the mRNA level and protein level. The 1H-NMR based metabolomics approach was applied to investigate the potential metabolic mechanism of the anti-inflammatory activity of 3-CT. Thirty-five metabolites were identified and assigned. Orthogonal signal correction partial least-squares discriminant analysis (OSC-PLS-DA) of the 1H-NMR data showed 3-CT could balance the significant changes in many endogenous metabolites (e.g., choline, glucose, phenylalanine) induced by LPS in RAW 264.7 cells, which related to cholinergic anti-inflammatory pathway, oxidative stress, energy metabolism, and amino acids metabolism. Conclusion 3-CT, isolated from the flowers of C. nitidissima Chi, had potent anti-inflammatory activity in LPS-activated RAW 264.7 cells. Furthermore, our results indicated that 3-CT had effects on the cholinergic anti-inflammatory pathway, oxidative stress, energy metabolism, and amino acids metabolism in LPS-activated RAW 264.7 cells.

scholarly journals Thermal stability of the prototypical Mn porphyrin-based superoxide dismutase mimic and potent oxidative-stress redox modulator Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride, MnTE-2-PyP5+

2013 ◽  
Vol 73 ◽  
pp. 29-34 ◽  
Author(s):  
Victor H.A. Pinto ◽  
Dayse CarvalhoDa-Silva ◽  
Jonas L.M.S. Santos ◽  
Tin Weitner ◽  
Maria Gardênnia Fonseca ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Thermal Stability ◽  
Superoxide Dismutase ◽  
Superoxide Dismutase Mimic ◽  
Thermal Stability Of

scholarly journals Skin protective effects of RM191A, a novel superoxide dismutase mimetic

2020 ◽  
Author(s):  
Artur Shariev ◽  
Alistair J. Laos ◽  
Donna Lai ◽  
Sheng Hua ◽  
Anna Zinger ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Wound Healing ◽  
Superoxide Dismutase ◽  
Human Skin ◽  
Skin Inflammation ◽  
Coordination Complex ◽  
Topical Gel ◽  
Anti Inflammatory

AbstractSuperoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin. RM191A is a water soluble, dimeric copper (Cu2+-Cu3+)-centred polyglycine coordination complex. It displays 10-fold higher superoxide quenching activity compared to SOD as well as significant anti-inflammatory activity through beneficial modulation of several significant inflammatory pathways in cells.We tested the therapeutic potential of RM191A in a topical gel using a human skin explant model and observed that it significantly inhibits UV-induced DNA damage in the epidermis and dermis, including cyclobutane pyrimidine dimers (CPD), 8-oxo-guanine (8-oxoG) and 8-nitroguanine (8NGO). RM191A topical gel is found to be safe and non-toxic in mice following month-long daily dosing at 0.19 mL/kg body weight. Moreover, it significantly accelerates excisional wound healing, and reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice.HighlightsSuperoxide dismutase mimetic RM191A is a highly stable copper (Cu2+-Cu3+)-polyglycine coordination complexRM191A exhibits potent antioxidant (10-fold more than that of superoxide dismutase) properties in vitroRM191A exhibits potent anti-inflammatory properties in vitro and in vivoRM191A protects human skin explants against UV-induced oxidative stress and DNA damageRM191A is non-toxic and readily bioavailable in miceRM191A attenuates TPA-induced skin inflammation and improves wound healing in mice

Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis

2016 ◽  
Vol 55 (1) ◽  
pp. 421-434 ◽  
Author(s):  
Chongshan Dai ◽  
Giuseppe D. Ciccotosto ◽  
Roberto Cappai ◽  
Shusheng Tang ◽  
Daowen Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Activity ◽  
N2a Cells ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory activity of berry fruits in mice model of inflammation is based on oxidative stress modulation

2016 ◽  
Vol 8 (5) ◽  
pp. 42 ◽  
Author(s):  
Claudriana Locatelli ◽  
GeissonMarcos Nardi ◽  
AdrianaGraziele de Farias anuário ◽  
CassioGeremia Freire ◽  
Fernanda Megiolaro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Activity ◽  
Mice Model ◽  
Anti Inflammatory ◽  
Berry Fruits
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