scholarly journals Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides

2020 ◽  
Vol 49 (7) ◽  
pp. 2323-2330
Author(s):  
Emilie Mathieu ◽  
Anne-Sophie Bernard ◽  
H. Y. Vincent Ching ◽  
Andrea Somogyi ◽  
Kadda Medjoubi ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Cell Penetrating Peptides ◽  
Inflammatory Activity ◽  
Intestinal Epithelial ◽  
Cell Penetrating ◽  
Anti Inflammatory ◽  
Superoxide Dismutase Mimic ◽  
Superoxide Dismutase Mimics

A superoxide dismutase mimic was functionalized with three peptides: -R9, -RRWWRRWRR or -Fx-r-Fx-K (MPP). They were studied in intestinal epithelial cells in an inorganic cellular chemistry approach: quantification, distribution and bio-activity.

Intestinal anti-inflammatory activity of luteolin: Role of the aglycone in NF-κB inactivation in macrophages co-cultured with intestinal epithelial cells

BioFactors ◽  
2013 ◽  
Vol 39 (5) ◽  
pp. 522-533 ◽  
Author(s):  
Yosuke Nishitani ◽  
Koji Yamamoto ◽  
Masaru Yoshida ◽  
Takeshi Azuma ◽  
Kazuki Kanazawa ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Inflammatory Activity ◽  
Intestinal Epithelial ◽  
Anti Inflammatory

scholarly journals Intestinal Anti-Inflammatory Activity of Lentinan: Influence on IL-8 and TNFR1 Expression in Intestinal Epithelial Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62441 ◽  
Author(s):  
Yosuke Nishitani ◽  
Ling Zhang ◽  
Masaru Yoshida ◽  
Takeshi Azuma ◽  
Kazuki Kanazawa ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Inflammatory Activity ◽  
Intestinal Epithelial ◽  
Anti Inflammatory

scholarly journals Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 328 ◽  
Author(s):  
Claudio Salaris ◽  
Melania Scarpa ◽  
Marina Elli ◽  
Alice Bertolini ◽  
Simone Guglielmetti ◽  
...  
Keyword(s):  
Immune Response ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Plaque Assay ◽  
Immune Response Gene ◽  
Intestinal Epithelial ◽  
Antiviral Immune Response ◽  
Qrt Pcr ◽  
Anti Inflammatory

SARS-CoV-2 is a newly emerging virus that currently lacks curative treatments. Lactoferrin (LF) is a naturally occurring non-toxic glycoprotein with broad-spectrum antiviral, immunomodulatory and anti-inflammatory effects. In this study, we assessed the potential of LF in the prevention of SARS-CoV-2 infection in vitro. Antiviral immune response gene expression was analyzed by qRT-PCR in uninfected Caco-2 intestinal epithelial cells treated with LF. An infection assay for SARS-CoV-2 was performed in Caco-2 cells treated or not with LF. SARS-CoV-2 titer was determined by qRT-PCR, plaque assay and immunostaining. Inflammatory and anti-inflammatory cytokine production was determined by qRT-PCR. LF significantly induced the expression of IFNA1, IFNB1, TLR3, TLR7, IRF3, IRF7 and MAVS genes. Furthermore, LF partially inhibited SARS-CoV-2 infection and replication in Caco-2 intestinal epithelial cells. Our in vitro data support LF as an immune modulator of the antiviral immune response with moderate effects against SARS-CoV-2 infection.

scholarly journals Anti-Inflammatory Properties of High Density Lipoprotein (HDL) on Intestinal Epithelial Cells

2011 ◽  
Vol 140 (5) ◽  
pp. S-838
Author(s):  
Ragam Attinkara ◽  
Lucia Rohrer ◽  
Gerd A. Kullak-Ublick ◽  
Gerhard Rogler ◽  
Jyrki J. Eloranta
Keyword(s):  
Epithelial Cells ◽  
High Density Lipoprotein ◽  
Intestinal Epithelial Cells ◽  
Density Lipoprotein ◽  
High Density ◽  
Intestinal Epithelial ◽  
Anti Inflammatory

scholarly journals Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex

2020 ◽  
Vol 56 (57) ◽  
pp. 7885-7888
Author(s):  
Emilie Mathieu ◽  
Anne-Sophie Bernard ◽  
Elodie Quévrain ◽  
Martha Zoumpoulaki ◽  
Sébastien Iriart ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Inflammatory Activity ◽  
Cellular Model ◽  
Intracellular Location ◽  
Anti Inflammatory ◽  
Superoxide Dismutase Mimic

The study of Mn-based superoxide dismutase mimic conjugated with a multimodal Re-probe in a cellular model of oxidative stress revealed that its bioactivity is associated with its accumulation at the mitochondria.

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