Glanzmann Thrombasthenia: A Case Report of a Rare Inherited Coagulation Disorder Presenting with Traumatic Head Injury

This case study deals with a 32-year-old Indian male patient who presented with a traumatic head injury in the hospital, experienced uncontrolled bleeding after conducting surgery, and was eventually diagnosed with Glanzmann thrombasthenia. Glanzmann thrombasthenia is a rare hereditary blood clotting disorder characterised by a lack of platelet aggregation due to the absence of platelet glycoprotein IIb/IIIa. This occurrence is generally triggered by consanguineous marriages and is apparent in approximately one in one million people. Education and raising awareness about consanguinity in communities may help to reduce challenging, unusual genetic diseases.

Hypercoagulability in COVID-19: A review of the potential mechanisms underlying clotting disorders

Severe acute respiratory syndrome coronavirus-2 has emerged as a new viral pandemic, causing Coronavirus disease 2019 (COVID-19) leading to a wide array of symptoms ranging from asymptomatic to severe respiratory failure. However, coagulation disorders have been found in some patients infected with SARS-CoV-2, leading to either a clotting disorder or hemorrhage. Several mechanisms attempt to explain the mechanism behind the pro-coagulant state seen with COVID-19 patients, including different receptor binding, cytokine storm, and direct viral endothelial damage. SARS-CoV-2 has also been recently found to bind to CLEC4M receptor, a receptor that participates in the clearance of von Willebrand Factor and Factor VIII. The competitive binding of SARS-CoV-2 to CLEC4M could lead to decreased clearance, and therefore a promotion of a pro-coagulative state; however, an experimental study needs to be done to prove such an association.

Bleeding complication after surgical removal of impacted teeth in a patient with undiagnosed clotting disorder

ABSTRACT To report one case of bleeding episodes after impacted teeth extractions had been performed in a patient with undiagnosed clotting disorder, describing a sequence of approaches for hemostasis up to the appropriated diagnosis and effective resolution. A male 16-year old patient with surgical indication to remove eight impacted teeth. After the surgery, there were bleeding episodes, being needed for hospital admission to keep on his physiological functions, blood pressure and heartbeat frequency regularly, to carry out laboratory blood tests, and to achieve hemostasis by using antifibrinolytics and blood products. After 24 hours, 11% of IX clotting factor was verified into bloodstream by specific blood test, being diagnosed with mild Hemophilia B. From the diagnosis, infusions of IX clotting factor were performed to the adequate resolution and recovery of the patient. The clinical conducts were efficient to keep on stable vital signs and achieving appropriate diagnosis. However, preventive behaviors should be applied in hemophilic patients in pre- or intra-operative, avoiding circumstances that can compromise health condition of the patient.

Trends in obstetric care statistics in the Russian Federation

An analysis of obstetric care statistics, which are considered as an indicator of the population’s health both now and in the future, seems relevant.Aim. To assess the dynamics of obstetric care data in Russia from 2006 to 2015 according to official statistics.Material and methods. The official statistics were analyzed using the descriptive statistic methods.Results. During the study period, the number of births in Russia increased by 30,1% and since 2012 has exceeded the level of 1991. We also revealed an increase in the prevalence of ectopic pregnancy (1,62-2,6% of all recorded pregnancies). A high level (~80%) of maternal morbidity over the past 6 years has remained. At the same time, there was a decrease in the incidence of maternal anemia, extragenital diseases, and gestosis. The prevalence of abnormal labor decreased over 10 years by 27,5% and amounted to 88,4 per 1,000 births in 2015, which is lower than in the 1991 (96,5‰). The incidence of labor bleeding decreased during the observation period by 11,4%. It is important that there was a decrease in the number of bleedings in the postpartum and postpartum period, and hemorrhages due to placenta previa and clotting disorder became more frequent. The number of caesarean sections has doubled over 10 years.Conclusion. The analysis shows the favorable trends in reproductive statistics in Russia — a decrease in reproductive losses, certain complications of pregnancy and labor. At the same time, decrease in the number of vaginal delivery and a high incidence of bleeding and sepsis specifies ways to improve the obstetric care service.