gene occurrence
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Author(s):  
Yiqing Wang ◽  
Aditi Batra ◽  
Hinrich Schulenburg ◽  
Tal Dagan

The emergence of antibiotic resistant bacteria is a major threat to modern medicine. Rapid adaptation to antibiotics is often mediated by the acquisition of plasmids carrying antibiotic resistance (ABR) genes. Nonetheless, the determinants of plasmid-mediated ABR gene transfer remain debated. Here, we show that the propensity of ABR gene transfer via plasmids is higher for accessory chromosomal ABR genes in comparison with core chromosomal ABR genes, regardless of the resistance mechanism. Analysing the pattern of ABR gene occurrence in the genomes of 2635 Enterobacteriaceae isolates, we find that 33% of the 416 ABR genes are shared between chromosomes and plasmids. Phylogenetic reconstruction of ABR genes occurring on both plasmids and chromosomes supports their evolution by lateral gene transfer. Furthermore, accessory ABR genes (encoded in less than 10% of the chromosomes) occur more abundantly in plasmids in comparison with core ABR genes (encoded in greater than or equal to 90% of the chromosomes). The pattern of ABR gene occurrence in plasmids and chromosomes is similar to that in the total Escherichia genome. Our results thus indicate that the previously recognized barriers for gene acquisition by lateral gene transfer apply also to ABR genes. We propose that the functional complexity of the underlying ABR mechanism is an important determinant of ABR gene transferability. This article is part of the theme issue ‘The secret lives of microbial mobile genetic elements’.





2020 ◽  
Author(s):  
Samah N. Abd ◽  
Najeh H. Kadhum ◽  
Hassan M. Abolmaali


2019 ◽  
Vol 26 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Ömer Akgül ◽  
Yunus Çetin ◽  
Gülhan Bora ◽  
Yaser Çetin ◽  
Müzeyyen Kaya


1999 ◽  
Vol 5 (6) ◽  
pp. 1147-1153
Author(s):  
M. A. El Hazmi ◽  
A. S. Warsy

A comprehensive national survey of the distribution of the sickle-cell [Hb S]gene and thalassaemia genes was initiated in 1982, with more than 30, 055 blood samples collected. The Hb S, alpha- and beta-thalassaemia gene frequency range was 0.005-0.145, 0.01-0.40 and 0.01-0.15 respectively in various areas of Saudi Arabia. We present here an appraisal of sickle-cell and thalassaemia gene occurrence in the Saudi population, based on our studies conducted over 10 years in different regions of Saudi Arabia



1990 ◽  
Vol 265 (8) ◽  
pp. 4600-4606 ◽  
Author(s):  
M Hijikata ◽  
J K Wen ◽  
T Osumi ◽  
T Hashimoto
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