Primary Large B Cell Lymphoma of the Cervix: A Case Report and review of literature

The primary diffuse large B cell lymphoma (DLBCL) of the uterine cervix is extremely rare. In the present study, we described two cases of DLBCL of the uterine cervix in reproductive-aged women complaining of postcoital bleeding, recurrent vaginal discharge, and abnormal uterine bleeding.

INCIDENCE OF CERVICAL ADENOCARCINOMA: A RETROSPECTIVE CASE STUDY AT RIMS RANCHI

BACKGROUND:Cervical cancer remains one of the most common causes of death for women globally and ranks 4th of all cancers.Currently,every 2 minutes a life is lost to this disease.Endocervical adenocarcinomas are a heterogeneous group of neoplasms. Screening strategies designed for and effective in detecting squamous cell carcinoma precursors are less effective in detecting endocervical glandular precursor lesions.Because of this and possible other reasons,the real and relative incidence of endocervical adenocarcinoma has increased in recent years from 5% to up to 20-25%, particularly in patients 30yr of age or older.MATERIAL AND METHOD: It was a retrospective record based study, performed in the Department of pathology, RIMS Ranchi. Study population included all cases who were clinically suspected of any cervical pathology, with common clinical presentation of abnormal vaginal bleeding, intermenstrual heavy bleeding,postmenopausal bleeding,postcoital bleeding,whitish discharge per vagina,pain in lower abdomen, from January 2020- july 2021.RESULT:In our study incidence of SCC of cervix is 91.97% and second most common type is adenocarcinoma of cervix with incidence of 8.02%.Striking feature of adenocarcinoma of cervix is its preponderance in younger female as compared to SCC

Evaluation of efficacy and safety of cryotherapy in benign and premalignant cervical lesion

Background: Cervical cancer ranks 3rd leading cause of cancer in the world. Cervical erosion is mostly asymptomatic in women but when symptoms like postcoital bleeding and vaginal discharge occur in the presence of cervical erosion, it becomes important to identify whether the erosion is a benign lesion or CIN or cancer by means of PAP smear and Biopsy. Treatment for benign and precancerous lesion can be provided by ablative or excisional methods. Cryotherapy was reliably used to treat cervical lesions.Methods: Women among 18 to 60 years of age attending outpatient department who had history of chronic discharge per vaginum, postcoital bleeding, dyspareunia, chronic pelvic pain. Patients were divided in two by PAP smear in erosion with inflammatory changes and presence of low grade squamous intraepithelial lesion. Cryotherapy was performed using double-freeze single session procedure. Each patient was followed up at 2, 6 and at 12 weeks. Complications and patients’ satisfaction were recorded and compared to calculate cure rate of symptoms, healing of lesion.Results: The healing efficacy of cryotherapy at 6th and 12th week was 87.8% and 91.1% respectively. Cryotherapy had high satisfaction rate. The cure rate was not affected by location of lesion and size of lesion in both inflammation and LSIL.Conclusions: Cryotherapy is an effective method for treatment of cervical erosion and effectively eliminates symptoms. Patients were highly satisfied. Cryotherapy is cheap, easy, and safe treatment. It is suitable for both hospital and office-based practice.

The outcome of colposcopy in women attending with persistent postcoital bleeding and negative HPV-DNA test

Objective: Women with postcoital bleeding (PCB) are recommended to be evaluated by colposcopy even if cytology is negative. Human papillomavirus (HPV) testing increases the detection of cervical intraepithelial neoplasia or worse compared to the Pap smear test. We aimed to determine the incidence of cervical pathology among women with persistent PCB with a negative Pap smear or HPV-DNA test. Our study, therefore, questions the place of HPV DNA test in women with PCB. Material and Methods: The clinical data of 212 women with persistent PCB and negative cytology or negative HPV DNA test referred to colposcopy, between January 2010 and June 2019, were retrospectively evaluated. Results: Among the 212 PCB patients, 161 (75.9%) were cytology negative and 51 (24.1%) were HPV DNA test (n=40) or co-test (n=11) (negative for HPV DNA test and cytology) negative. There were no cases of invasive cancer. The women referred with negative cytology were more likely than those with negative HPV DNA to have CIN (21/161 (13%), 1/51 (1.9%) p=0.042. Seven women (4.3%) were diagnosed with high-grade cervical dysplasia in the negative cytology group. None of the patients in the HPV DNA negative group was diagnosed with high-grade cervical dysplasia. Conclusion: Our data show that a normal Pap smear cytology in women with PCB does not rule out the possibility of HSIL. HPV DNA testing is a useful triage test to determine if colposcopy referral is required in the context of post-coital bleeding with negative smear test.

Post coital bleeding is a risk for cervical cell abnormality

Postcoital bleeding is a worrying, for both women and health care provider. This study aimed to evaluate the prevalence of abnormal cervical cytology among patient with PCB in the private outpatient care setting, and to identify risk-factors for cervical pathology among these patients. A cross sectional study of 90 patients presented to the privet clinic, during the period 1st feb-1st Des. 2019. Inclusion criteria include married women presented with post coital bleeding, non-pregnant, all patients undergo Pap Smear Cytology. The commonest age presented with PCB was 40-44 years old 22(24.4%), followed by (45-49) years and (25-29) years 18(20%). Those aged ≥40 years 44(48.9%), and those aged ≤34 34(37.8%). The mean parity was 4.7±2.8, hormonal contraception was commonly used by those with PCB followed by intra uterine contraceptive device (IUCD), 30(33.3%), 18(20) respectively. Most of the patient were House wives 78(86.7%), The physical examination show that most patient had cervical erosion 68(75.5%), followed by healthy cervix in 12(13.3%), while suspicious features was found among 6(6.7%), Moderate and sever dysplasia was found more among those aged ≥40 years 10(22.7%), while it was 4(8.7%) among those aged < 40 years. there is higher prevalence of High-grade squamous intraepithelial lesions among females with PCB, and non- significant difference among those aged less or more than 40 years. Therefore it’s important to examine any patient complaining of PCB with PAP smear cytology and colposcopy examination.