11H-Indeno[1,2-b]quinoxalin-11-one 2-(4-ethylbenzylidene)hydrazone

11H-Indeno[1,2-b]quinoxaline derivatives present an important type of nitrogen-containing heterocyclic compound that are useful intermediate products in organic synthesis and have potential pharmaceutical applications. A new 11H-indeno[1,2-b]quinoxalin-11-one-2-(4-ethylbenzylidene)hydrazone (compound 3) was synthesized. Compound 3 is the first example of an azine derivative based on the 11H-indeno[1,2-b]quinoxaline system. The Z,E-isomerism of compound 3 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME predictions. According to the ADME results, compound 3 is potentially highly bioavailable and has potential to be used for the treatment of neuroinflammation and ischemia–reperfusion injury.

Evaluating the role of a urea-like motif in enhancing the thermal and mechanical strength of supramolecular gels

Enhanced thermal and mechanical strength in semicarbazone gels with a urea-like motif obtained by modifying the hydrogen bonding motif of the hydrazone compound.

(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was characterized by IR, 1D, and 2D NMR analyses. Experimental induction of MI in rats was established by ISO (85 mg/kg/day, s.c) for two consecutive days (6th and 7th days). 7-hyd.HC or sintrom was given for 7 days prior and simultaneous to ISO injection. 7-hyd.HC offered a cardiopreventive effect by preventing heart injury marker leakage (LDH, ALT, AST, CK-MB, and cTn-I) from cardiomyocytes and normalizing cardiac function and ECG pattern, as well as improving lipid profile (TC, TG, LDL-C, and HDL-C), which were altered by ISO administration. Moreover, 7-hyd.HC precotreatment significantly mitigated the oxidative stress biomarkers, as evidenced by the decrease of lipid peroxidation and the increased level of the myocardial GSH level together with the SOD, GSH-Px, and catalase activities. 7-hyd.HC inhibited the cardiac apoptosis by upregulating the expression of Bcl-2 and downregulating the expression of Bax and caspase-3 genes. In addition, 7-hyd.HC reduced the elevated fibrinogen rate and better prevented the myocardial necrosis and improved the interstitial edema and neutrophil infiltration than sintrom. Overall, 7-hyd.HC ameliorated the severity of ISO-induced myocardial infarction through improving the oxidative status, attenuating apoptosis, and reducing fibrinogen production. The 7-hyd.HC actions could be mediated by its antioxidant, antiapoptotic, and anti-inflammatory capacities.

Senyawa Hidrazone dari Vanilin-DNPH Sebagai Sensor Kolorimetri Anion Sianida

<p>Senyawa hidrazon (<em>E</em>)-4-((2-(2,4-<em>dinitrophenyl</em>)<em>hydrazineylidene</em>)<em>methyl</em>)-2-<em>methoxyphenol</em> telah disintesis dari vanilin dan 2,4-dinitrofenilhidrazin (DNPH). Uji sensor anion dilakukan dengan menambahkan anion F^-, Cl^-, Br^-, I^-, CN^-, SO₄^2-, CO₃^2-, CH₃COO^- dan H₂PO₄^- dalam pelarut asetonitril. Uji limit deteksi reseptor (<em>E</em>)-4-((2-(2,4-<em>dinitrophenyl</em>)<em>hydrazineylidene</em>)<em>methyl</em>)-2-<em>methoxyphenol</em> terhadap anion sianida dilakukan dalam pelarut asetonitril. Hasil uji sensor anion menunjukan bahwa reseptor selektif terhadap anion sianida dengan menghasilkan perubahan warna dari kuning ke merah. Hasil analisa dengan spektrofotometer UV-Vis reseptor memberikan perubahan panjang gelombang dari 395 nm menjadi 472 nm pada penambahan anion sianida. Reseptor (<em>E</em>)-4-((2-(2,4-<em>dinitrophenyl</em>)<em>hydrazineylidene</em>)<em>methyl</em>)-2-<em>methoxyphenol</em> dapat mendeteksi anion CN- dengan limit deteksi sebesar 7 mM.</p><p> </p><p><strong>A Hydrazone Compound from Vanillin-DNPH as Colorimetric Sensor of Cyanide Anion</strong><strong>.</strong> A hydrazone compound (<em>E</em>)-4-((2-(2,4-dinitrophenyl)hydrazineylidene)methyl)-2-methoxyphenol has been synthesized from vanillin and 2,4-dinitrophenylhydrazine (DNPH). The anion sensor study were done by adding Br^-_,CN^-, F^-, SO₄^2-_,Cl^-, I^- , CO₃^2-, CH₃COO^- and H₂PO₄^- anion in acetonitrile solvent. The detection limit study of receptor <em>E</em>)-4-((2-(2,4-dinitrophenyl)hydrazineylidene)methyl)-2-methoxyphenol for cyanide anion was carried out in acetonitrile. The result of anion sensor study shows that the receptor was selective to cyanide anion by providing change of color from yellow to red. The analysis result using spectrophotometer ultraviolet-visible of the receptor provided change of maximum wavelength from 395 nm to 472 nm when the cyanide anion was added. Receptor (<em>E</em>)-4-((2-(2,4-dinitrophenyl) hydrazineylidene)methyl)-2-methoxyphenol can detect CN^- with limit of detection 7 mM.</p><div><span><br /></span></div>

Development of a chiral RP-HPLC method for identification of stereomers of newly synthesized xanthine-based hydrazide-hydrazone compound

A reversed phase enantio selective high performance liquid chromatographic method was developed for enantiomeric separation of 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purine-7(6H)-yl)-N'-(3-fluorobenzylidene)-propanehydrazide isomers. The enantiomers of 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purine-7(6H)-yl)-N'-(3-fluorobenzylidene)propanehydra-zide were resolved on a ACEÒEquivalenceTM С18 (250 × 4.6 mm, 5 μm) column using a mobile phase system containing methanol, water, phosphate buffer рН 7.4 (50:46:4 v/v/v). The resolution between enantiomers was found to be more than 2.0. The sample solution and mobile phase were found to be stable for at least 48 h. The final optimized method was successfully applied to separate the (R)- and the (S)-enantiomers of 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purine-7(6H)-yl)-N'-(3-fluorobenzylidene)-propanehydrazide and was proven to be reproducible and accurate.

Supramolecular catalytic synthesis of a novel bis(salicylaldehyde hydrazone) ligand for ratiometric recognition of AT-DNA

A bis-hydrazone compound (2) was synthesized via supramolecular catalysis under physiological conditions and its AT-DNA ratiometric sensing properties were identified.