Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media

Pharmaceuticals wastes have been recognized as emerging pollutants to the environment. Among those, antibiotics in the aquatic environment are one of the major sources of concern, as chronic, low-dose exposure can lead to antibiotic resistance. Herein, we report on molecularly imprinted polymers (MIP) to recognize penicillin V potassium salt (PenV-K), penicillin G potassium salt (PenG-K), and amoxicillin sodium salt (Amo-Na), which belong to the most widespread group of antibiotics worldwide. Characterization and optimization led to two MIPs comprising methacrylic acid as the monomer and roughly 55% ethylene glycol dimethacrylate as the crosslinker. The obtained layers led to sensitive, selective, repeatable, and reusable sensor responses on quartz crystal microbalances (QCM). The LoD for PenV-K, PenG-K, and Amo-Na sensors are 0.25 mM, 0.30 mM, and 0.28 mM, respectively; imprinting factors reach at least around three. Furthermore, the sensors displayed relative selectivity factors of up to 50% among the three penicillins, which is appreciable given their structural similarity.

Insight into amoxicillin sodium heterosolvates and non-solvated form: crystal structures, phase transformation behaviors, and desolvation mechanism

Amoxicillin sodium heterosolvates, including SM-M (methanol–methyl acetate solvate), SE-M (ethanol–methyl acetate solvate), and SM-E (methanol–ethyl acetate solvate), were obtained for the first time in this work. The single crystal of...

Application of HPLC-DAD and spectrophotometric continuous wavelet transform methods for simultaneous determination of amoxicillin and diclofenac in their pure and capsule dosage forms

Two methods have been developed and validated for simultaneous determination of amoxicillin sodium and diclofenac sodium in their pure and combined pharmaceutical dosage forms.