scholarly journals Mucinous Adenocarcinoma Transformation in Ovarian Mature Cystic Teratoma Complicating Pregnancy: A Case Report

2021 ◽  
Author(s):  
Hajar Abbasi ◽  
Saloomeh Mohammadi ◽  
Atefeh Moridi ◽  
Athena Behforouz
Keyword(s):  
Mature Teratoma ◽  
Cystic Teratoma ◽  
Expectant Management ◽  
Mucinous Cystadenocarcinoma ◽  
Adnexal Masses ◽  
Secondary Neoplasm ◽  
One Year ◽  
Stage 1 ◽  
Disease Free

Most adnexal masses found in pregnancy are simple benign cysts less than 5 cm in diameter. On the other hand, the majority of persistent adnexal masses 5 cm or greater in diameter are mature teratomas. Malignant transformation occurs in 0.2 to 2 percent of mature teratomas, and squamous cell carcinoma arising from ectoderm is the most common secondary neoplasm. The mucinous cystadenocarcinoma transformation is very rare. We presented a 38-year-old G2Ab1 woman at 32 weeks of gestation with a huge, rapid growth adnexal mass who came to our emergency department due to severe preeclampsia, stage 1 of IUGR, and borderline AFI. After 48 hours of expectant management, a cesarean section associated with unilateral salpingooophorectomy was done, and the histopathology of the cyst revealed mature teratoma that was focally involved with mucinous cystadenocarcinoma. The complete surgical staging was done, and due to the stage of disease (1C1), she received adjuvant chemotherapy, and she has remained disease-free in her last follow up after one year.

Intensive Fostering: An Independent Evaluation of MTFC in an English Setting

2012 ◽  
Vol 36 (1) ◽  
pp. 13-26 ◽  
Author(s):  
Nina Biehal ◽  
Sarah Ellison ◽  
Ian Sinclair
Keyword(s):  
Young People ◽  
Total Sample ◽  
High Risk Group ◽  
Eligibility Criteria ◽  
Independent Evaluation ◽  
Quasi Experimental ◽  
One Year ◽  
Stage 1 ◽  
Official Data

Nina Biehal, Sarah Ellison and Ian Sinclair present the results of an independent evaluation of the Multidimensional Treatment Foster Care (MTFC) programme for young offenders in England, where it is known as Intensive Fostering (IF). A quasi-experimental, mixed-methods study was carried out at the three pilot sites, with a total sample of 47 at follow-up. Young people sentenced to IF were compared to a similar group, matched on the eligibility criteria for IF, the majority of whom were sentenced to custody. The groups were well matched in terms of their characteristics and criminal histories. Official data on reconviction were collected at baseline and one year after entry to the IF placement or release from custody (Stage 1), and further data on programme completion and secondary outcomes were collected via interviews with young people and parents, and questionnaires to professionals at baseline and follow-up. Official data on reconviction were also collected one year after exit from the IF placements (Stage 2). At Stage 1 the IF group were less likely to be reconvicted, had committed fewer and less-serious recorded offences, on average, and took longer to commit their first recorded offence. At this point the IF group were more likely to be living with their families and less likely to be in custody than the comparison group. However, by Stage 2 no significant differences in patterns of reconviction remained. IF successfully contained a high-risk group in the community, but the effects of the intervention diminished once they left their foster placements. Environmental effects on entry to and exit from the IF placements may help to explain the results at both stages.

Mucinous appendiceal tumors of uncertain malignant potential (UMP): Prognostic factors and implications for treatment and follow-up.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 372-372 ◽  
Author(s):  
K. F. Fournier ◽  
R. Royal ◽  
L. A. Lambert ◽  
M. Taggart ◽  
S. Rafeeq ◽  
...  
Keyword(s):  
Overall Survival ◽  
Elevated Serum ◽  
Disease Free Survival ◽  
Expectant Management ◽  
Ca 125 ◽  
Free Survival ◽  
Clinicopathologic Factors ◽  
Operative Findings ◽  
Disease Free

372 Background: The diagnosis of UMP is used for dysplastic mucinous tumors that are difficult to classify as clearly benign or malignant. Given the rarity of this tumor, management of these patients is unclear. Methods: All patients with a pathologic diagnosis of an appendiceal mucinous UMP who underwent evaluation at a single institution between September 1993 and July 2009 were retrospectively reviewed. Patient demographics, operative findings, pathology, tumor markers, procedures performed, recurrence, overall survival, and disease-free survival were determined. Results: Of 688 patients with appendiceal neoplasms, 62 (9%) patients (pts) were identified as having UMP. Initial procedures included: appendectomy - 45, colectomy - 11, cytoreduction - 2, and other - 4. Median follow-up was 43.2 months (range 2-184 mos). Median overall survival (OS) was 11.5 years (range 2-184 mos). Median disease-free survival (DFS) has not been reached. There was a trend towards improved DFS in patients who are: female, < 65 years of age, or have mucin confined to the appendix or its serosal surface. Clinicopathologic factors associated with a significantly worse overall DFS included elevated serum CEA (3.6 years, p = 0.0129) and CA-125 (4.16 years, p = 0.0288). DFS at 8 years follow-up in patients with a normal CEA was as follows: 100% if mucin confined to lumen of the appendix, 90% if mucin confined to serosa, and 69% if mucin was in an extra-appendiceal location. 15 patients developed recurrent disease and had an OS of 4.6 years after recurrence. Conclusions: Mucinous UMP tumors of the appendix have an overall favorable prognosis. In patients with a negative margin and mucin confined to the appendix or serosa, expectant management may be sufficient. Elevation of CEA or CA-125 may warrant closer monitoring or intervention. If confirmed in a larger cohort, these findings may have substantial implications for management of these patients. No significant financial relationships to disclose.

Utility of neutrophil to lymphocyte ratio in predicting colorectal cancer prognosis at a VA hospital: Do stage and sidedness matter?

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16110-e16110
Author(s):  
Kee-Hwan Michael Kim ◽  
Darren Gemoets ◽  
Maithao N. Le
Keyword(s):  
Colorectal Cancer ◽  
Recurrent Disease ◽  
Disease Free Survival ◽  
Free Survival ◽  
Lymphocyte Ratio ◽  
One Year ◽  
Stage 1 ◽  
Disease Free ◽  
Worse Prognosis ◽  
Time Of Collection

e16110 Background: Pretreatment neutrophil-lymphocyte ratio (pNLR) has been shown to associate with prognosis in patients with colorectal cancer (CRC). We asked if pNLR equally predicted prognosis in CRC regardless of stage and tumor location. We also asked if pNLR changed with time, especially within one year of diagnosis. Methods: Retrospective clinical data including age at diagnosis, pathological stage, location of tumors, treatments, disease free survival, NLR at one week, three months, and one year (if available) pretreatment of 934 veterans treated for CRC at one Veteran Affair Medical Center between July 1995 and December 2011 were collected. Disease-free survival (DFS) were analyzed using Kaplan-Meier analysis and compared using the log-rank test. pNLRs were grouped into three categories: less than or equal to three, greater than three and less than or equal to five, and greater than five. Univariate and multivariate Cox regression analyses were used to identify the prognostic value of pNLR. Boxplot analysis was used to evaluate the changes in pNLR over time. Results: In patients with stage 1 or stage 4 CRC, pNLRs of more than 5 and not between 3 and 5 predicted worse prognosis. In patients with stage 2 or 3 CRC, pNLRs did not correlate with prognosis. Interestingly, for patients with recurrent CRC after curative treatment, NLRs obtained prior to treatment of recurrent disease of more than 3 associated with worse prognosis. In subgroup analysis, we found that in patients with stage 1 or 4 left side colon or rectal cancer (LCRC), pNLRs of more than 5 but not between 3 and 5 predicted worse prognosis. In patients with stage 2 or 3 LCRC, NLRs obtained prior to treatment of recurrent disease did not correlate with prognosis. Similarly, for patients with recurrent LCRC after curative treatment, NLRs obtained prior to treatment of recurrent disease of more than 3 associated with worse prognosis. pNLRs did not correlate with prognosis in patients with right side colon cancer (RCC) regardless of stage. When comparing NLRs obtained at 1 year, 3 months, and 1-week pretreatment, boxplots showed a gradual increase leading up to the time of treatment suggesting that NLR changes according to the time of collection. Conclusions: In our large retrospective study, the role of pNLR in predicting oncologic prognosis differed according to the stage and the sidedness of the CRC. In addition, the value of pNLR varied depending on the time of collection. These findings suggested a complex relationship between immunologic parameters and oncologic survival.

scholarly journals Hysterectomy optimization technology in patients with overweight

2020 ◽  
Vol 3 (13) ◽  
pp. 22-26
Author(s):  
B. Khabrat ◽  
O. Lytvak ◽  
B. Lysenko ◽  
A. Khabrat ◽  
V. Pasko
Keyword(s):  
High Frequency ◽  
Uterine Fibroids ◽  
Control Group ◽  
Proximal Point ◽  
Testing Method ◽  
Inflammatory Processes ◽  
Serious Injury ◽  
One Year ◽  
Stage 1

Aim. The aim of our work was the development and testing method of hysterectomy, which would greatly facilitate radical hysterectomy in patients who are overweight. Materials and methods. In the main group of supervision were included 76 women who had 0 and stage 1 prolapse by POP-Q classification and were operated under minimally invasive surgery of RPCPCM in the period from 2019 to 2020because of uterine fibroids by the method developed by us.The control group consisted of 50 women whom was performed intrafascial hysterectomy by the method of Oldridge. To study the vaginal profile marked by two indicators: the length of the vagina and the range of displacement of the proximal point of the vagina (apex), which were determined before surgery and 24 months after surgery at intervals of one year. Determining the length of the vagina was performed in the supine position, immediately determine the most proximal point of the vagina. Results and discussion Conclusions. Methods of intrafascial hysterectomy using high-frequency diathermy are effective in preventing prolapse stump and shortening of the vagina. Shortening of the vagina in patients in the control group may have been caused by the degenerative processes due to serious injury of support structures and vessels of proximal vagina with the emergence in this context of inflammatory processes in the stump. Shortening of the vagina in patients operated on the proposed method was observed. Trends shortening of the vagina or prolapse at follow-up were found.

scholarly journals One-Year Progression and Risk Factors for the Development of Chronic Kidney Disease in Septic Shock Patients with Acute Kidney Injury: A Single-Centre Retrospective Cohort Study

2018 ◽  
Vol 7 (12) ◽  
pp. 554 ◽  
Author(s):  
June-sung Kim ◽  
Youn-Jung Kim ◽  
Seung Ryoo ◽  
Chang Sohn ◽  
Dong Seo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Septic Shock ◽  
Acute Kidney Injury ◽  
Cohort Study ◽  
Retrospective Cohort ◽  
Kidney Injury ◽  
One Year ◽  
Stage 1

(1) Background: Sepsis-associated acute kidney injury (AKI) can lead to permanent kidney damage, although the long-term prognosis in patients with septic shock remains unclear. This study aimed to identify risk factors for the development of chronic kidney disease (CKD) in septic shock patients with AKI. (2) Methods: A single-site, retrospective cohort study was conducted using a registry of adult septic shock patients. Data from patients who had developed AKI between January 2011 and April 2017 were extracted, and 1-year follow-up data were analysed to identify patients who developed CKD. (3) Results: Among 2208 patients with septic shock, 839 (38%) had AKI on admission (stage 1: 163 (19%), stage 2: 339 (40%), stage 3: 337 (40%)). After one year, kidney function had recovered in 27% of patients, and 6% had progressed to CKD. In patients with stage 1 AKI, 10% developed CKD, and mortality was 13% at one year; in patients with stage 2 and 3 AKI, the CKD rate was 6%, and the mortality rate was 42% and 47%, respectively. Old age, female, diabetes, low haemoglobin levels and a high creatinine level at discharge were seen to be risk factors for the development of CKD. (4) Conclusions: AKI severity correlated with mortality, but it did not correlate with the development of CKD, and patients progressed to CKD, even when initial AKI stage was not severe. Physicians should focus on the recovery of renal function, and ensure the careful follow-up of patients with risk factors for the development of CKD.

scholarly journals Effectiveness of a Global Multidisciplinary Supportive and Educational Intervention in Thermal Resort on Anthropometric and Biological Parameters, and the Disease-Free Survival after Breast Cancer Treatment Completion (PACThe)

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Marie-Paule Vasson ◽  
Fabrice Kwiatkowski ◽  
Adrien Rossary ◽  
Sylvie Jouvency ◽  
Marie-Ange Mouret-Reynier ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Disease Free Survival ◽  
Recurrence Risk ◽  
Breast Cancer Treatment ◽  
Biological Parameters ◽  
Free Survival ◽  
One Year ◽  
Disease Free

A growing knowledge highlights the strong benefit of regular physical activity in the management of breast cancer patients, but few studies have considered biological parameters in their outcomes. In the prospective randomised trial after breast cancer treatment completion “PACThe,” we determined the effects of physical activity and nutritional intervention on the biological and anthropometric status of patients after one year of follow-up, and clarified the link between biomarkers at allocation and disease-free survival. 113 patients from the population of the “PACThe” study (n = 251) were analysed for biological parameters. Patients were randomized after chemotherapy in two arms: the intervention “SPA” receiving a 2-week session of physical training, dietary education, and physiotherapy (n = 57), and the control “CTR” (n = 56). Diet questionnaire, anthropometric measures, and blood parameters were determined at allocation and one year later. Survival and recurrence were checked over 7 years. Data were considered as a function of BMI, i.e., ≤25 for normal, 25–30 for overweight, and >30 for obese patients. At allocation, the large standard deviation for nutrient-intake values reflected an unbalanced diet for some patients in the three groups. At one-year follow-up, we noticed an increase in glucose (p<10−6), insulin (p<10−7), and adiponectin (p<0.022) plasma levels for both intervention arms, which were more accentuated for the >30 groups. Using the Cox model, we demonstrated that the highest testosterone plasma values were linked to an increase of the recurrence risk (HR [CI–95%] = 5.06 [1.66–15.41]; p=0.004). One-year after a global multidisciplinary supportive and educational intervention, we found few anthropometric and biological changes, mainly related to the patient’s initial BMI. We highlighted the importance of plasma testosterone in the evaluation of patient’s recurrence risk. Future studies would help better understand the mechanisms by which such multidisciplinary interventions could interact with breast cancer recurrence and define the most effective modalities.

scholarly journals The Uterine Adenosarcoma in a Young Woman Treated by TAH/BOS and Combined Adjuvant Therapy: A Case Report

2020 ◽  
Author(s):  
Soodabeh Shahidsales ◽  
Marjaneh Farazestanian ◽  
Noorieh Sharifi‐Sistani ◽  
Sara Rasta ◽  
Seyed Alireza Javadinia
Keyword(s):  
Adjuvant Therapy ◽  
Myometrial Invasion ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Advanced Stage ◽  
Deep Myometrial Invasion ◽  
One Year ◽  
Disease Free

We aimed to report a woman suffering from uterine adenosarcoma in the perimenopause period. The patient had undergone total abdominal hysterectomy (TAH) with bilateral salpingo-oophorectomy (BSO) and also received adjuvant chemotherapy and radiotherapy. Moreover, she was reported as disease-free with no evidence of recurrence or metastasis despite the existence of numerous risk factors such as deep myometrial invasion as well as sarcomatous overgrowth after one year of follow-up. The results obtained about this patient could highlight the role of adjuvant therapy in terms of managing treatments for patients suffering from MASO, especially in the presence of deep myometrial invasion and an advanced stage.

scholarly journals Three Cases of Immature Teratoma Diagnosed after Laparoscopic Operation

2014 ◽  
Vol 7 ◽  
pp. CCRep.S17455 ◽  
Author(s):  
Masakazu Nishida ◽  
Yasushi Kawano ◽  
Akitoshi Yuge ◽  
Kaei Nasu ◽  
Harunobu Matsumoto ◽  
...  
Keyword(s):  
Young Women ◽  
Ovarian Tumor ◽  
Mature Teratoma ◽  
Cystic Teratoma ◽  
Immature Teratoma ◽  
Mature Cystic Teratoma ◽  
Fluid Content ◽  
Laparoscopic Operation ◽  
Ovarian Cancers

While mature cystic teratoma of the ovary is the most common ovarian tumor in young women, immature teratoma is a very rare tumor, representing only 1% of all ovarian cancers. In the three cases presented here, young women who were suspected to have mature cystic teratoma, based on CT scan and MRI, were ultimately diagnosed with immature teratoma Ic (b) G1 after laparoscopic operation. They underwent salpingo-oophorectomy of the affected side only and have shown no sign of recurrence during follow-up. We sometimes encounter patients with immature teratoma who have no findings pointing to malignancy on CT or MRI. Generally, if the components of immature nerve cells that represent immature teratoma are very few, it is difficult to diagnose the entity as immature teratoma with imaging evaluations such as CT or MRI. In many hospitals, laparoscopic surgery is selected for patients with ovarian mature teratoma. Therefore, it is essential to attempt as much as possible not to disseminate the fluid content of the tumor into the intra-abdominal space during laparoscopic operation, because in rare cases the tumor turns out not to be benign mature teratoma.

Testis-Preserving Tumor Enucleation Is Applicable in Children with Immature Testicular Teratoma

2020 ◽  
pp. 1-4
Author(s):  
Zhenwu Li ◽  
Weiping Zhang ◽  
Hongcheng Song ◽  
Ning Sun
Keyword(s):  
Mature Teratoma ◽  
Disease Free Survival ◽  
Biological Characteristics ◽  
Benign Tumors ◽  
Course Of Disease ◽  
Free Survival ◽  
Tumor Enucleation ◽  
Disease Free ◽  
Main Clinical Manifestation

<b><i>Introduction:</i></b> This study investigated the biological characteristics of immature testicular teratoma in children and explored the feasibility of testis-preserving tumor enucleation. <b><i>Methods:</i></b> We retrospectively reviewed the cases of 23 children who received a pathologic diagnosis of immature testicular teratoma between January 2005 and December 2018. Ages ranged from 16 days to 13 months (mean: 6 months and 5 days). Painless testicular enlargement was the main clinical manifestation, and the course of disease ranged from 20 days to 4 months (mean: 1.4 months). The tumor volume ranged from 1.5 × 1.2 × 0.5 to 6 × 5 × 4.5 cm. Elevated levels of alpha-fetoprotein were measured in 21 patients. Preoperative ultrasound examination showed a cystic/solid mass with calcification. <b><i>Results:</i></b> Excision of the affected testis was done in 10 patients and testis-preserving tumor excision in 13 patients. Postoperative chemotherapy was not employed. Nineteen patients were followed up for 1–10 years, and all showed disease-free survival without recurrence or metastasis. <b><i>Conclusion:</i></b> Immature testicular teratoma is found predominantly in children aged &#x3c;1 year, and its biological characteristics are different from those in adults. Immature testicular teratoma is largely benign in children and can be managed by testis-preserving tumor enucleation, as for other benign tumors (such as mature teratoma). Postoperative monitoring and follow-up are necessary.

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