Strong intracellular signal inactivation produces sharper and more robust signaling from cell membrane to nucleus

For a chemical signal to propagate across a cell, it must navigate a tortuous environment involving a variety of organelle barriers. In this work we study mathematical models for a basic chemical signal, the arrival times at the nuclear membrane of proteins that are activated at the cell membrane and diffuse throughout the cytosol. Organelle surfaces within human B cells are reconstructed from soft X-ray tomographic images, and modeled as reflecting barriers to the molecules’ diffusion. We show that signal inactivation sharpens signals, reducing variability in the arrival time at the nuclear membrane. Inactivation can also compensate for an observed slowdown in signal propagation induced by the presence of organelle barriers, leading to arrival times at the nuclear membrane that are comparable to models in which the cytosol is treated as an open, empty region. In the limit of strong signal inactivation this is achieved by filtering out molecules that traverse non-geodesic paths.

Geodesic Loewner paths with varying boundary conditions

Equations of the Loewner class subject to non-constant boundary conditions along the real axis are formulated and solved giving the geodesic paths of slits growing in the upper half complex plane. The problem is motivated by Laplacian growth in which the slits represent thin fingers growing in a diffusion field. A single finger follows a curved path determined by the forcing function appearing in Loewner’s equation. This function is found by solving an ordinary differential equation whose terms depend on curvature properties of the streamlines of the diffusive field in the conformally mapped ‘mathematical’ plane. The effect of boundary conditions specifying either piecewise constant values of the field variable along the real axis, or a dipole placed on the real axis, reveal a range of behaviours for the growing slit. These include regions along the real axis from which no slit growth is possible, regions where paths grow to infinity, or regions where paths curve back toward the real axis terminating in finite time. Symmetric pairs of paths subject to the piecewise constant boundary condition along the real axis are also computed, demonstrating that paths which grow to infinity evolve asymptotically toward an angle of bifurcation of π /5.

Information Geometric Perspective on Off-Resonance Effects in Driven Two-Level Quantum Systems

We present an information geometric analysis of off-resonance effects on classes of exactly solvable generalized semi-classical Rabi systems. Specifically, we consider population transfer performed by four distinct off-resonant driving schemes specified by su 2 ; ℂ time-dependent Hamiltonian models. For each scheme, we study the consequences of a departure from the on-resonance condition in terms of both geodesic paths and geodesic speeds on the corresponding manifold of transition probability vectors. In particular, we analyze the robustness of each driving scheme against off-resonance effects. Moreover, we report on a possible tradeoff between speed and robustness in the driving schemes being investigated. Finally, we discuss the emergence of a different relative ranking in terms of performance among the various driving schemes when transitioning from on-resonant to off-resonant scenarios.