Word Prosody in Lung’Ie: One System or Two?

Creole languages have generally not figured prominently in cross-linguistic studies of word-prosodic typology. In this paper, we present a phonological analysis of the prosodic system of Lung’Ie or Principense (ISO 639-3 code: pre), a Portuguese-lexifier creole language spoken in São Tomé and Príncipe. Lung’Ie has produced a unique result of the contact between the two different prosodic systems common in creolization: a stress-accent lexifier and tone language substrates. The language has a restrictive privative H/Ø tone system, in which the /H/ is culminative, but non-obligatory. Since rising and falling tones are contrastive on long vowels, the tone must be marked underlyingly. While it is clear that tonal indications are needed, Lung’Ie reveals two properties more expected of an accentual system: (i) there can only be one heavy syllable per word; (ii) this syllable must bear a H tone. This raises the question of whether syllables with a culminative H also have metrical prominence, i.e. stress. However, the problem with equating stress with H tone is that Lung’Ie has two kinds of nouns: those with a culminative H and those which are toneless. The nouns with culminative H are 87% of Portuguese origin, incorporated through stress-to-tone alignment, while the toneless ones are 92% of African origin. Although other creole languages have been reported with split systems of “accented” vs. fully specified tonal lexemes, and others with mixed systems of tone and stress, Lung’Ie differs from these cases in treating African origin words as toneless, a quite surprising result. We consider different analyses and conclude that Lung’Ie has a privative /H/ tone system with the single unusual stress-like property of weight-to-tone.

Word Prosody in Lung’Ie: One System or Two?

Creole languages have generally not figured prominently in cross-linguistic studies of word-prosodic typology. In this paper, we present a phonological analysis of the prosodic system of Lung’Ie or Principense (ISO 639-3 code: pre), a Portuguese-based creole language spoken in São Tomé and Príncipe. Lung’Ie has produced a unique result of the contact between the two different prosodic systems common in creolization: a stress-accent lexifier and tone language substrates. The language has a restrictive privative H/Ø tone system, in which the /H/ is culminative, but non-obligatory. Since rising and falling tones are contrastive on long vowels, the tone must be marked underlyingly. While it is clear that tonal indications are needed, Lung’Ie reveals two properties more expected of an accentual system: (i) there can only be one heavy syllable per word; (ii) this syllable must bear a H tone. This raises the question of whether syllables with a culminative H also have metrical prominence, i.e. stress. However, the problem with equating stress with H tone is that Lung’Ie has two kinds of nouns: those with a culminative H and those which are toneless. The nouns with culminative H are 87% of Portuguese origin, incorporated through stress-to-tone alignment, while the toneless ones are 92% of African origin. Although other creole languages have been reported with split systems of “accented” vs. fully specified tonal lexemes, and others with mixed systems of tone and stress, Lung’Ie differs from these cases in treating African origin words as toneless, a quite surprising result. We consider different analyses and conclude that Lung’Ie has a privative /H/ tone system with the single unusual stress-like property of weight-to-tone.

Cprp—An Unusual, Repetitive Protein Which Impacts Pleuromutilin Biosynthesis in the Basidiomycete Clitopilus passeckerianus

Interrogation of an EST database for Clitopilus passeckerianus identified a putative homolog to the unusual stress response gene from yeast; ddr48, as being upregulated under pleuromutilin production conditions. Silencing of this gene, named cprp, produced a population of transformants which demonstrated significantly reduced pleuromutilin production. Attempts to complement a Saccharomyces cerevisiae ddr48 mutant strain (strain Y16748) with cprp were hampered by the lack of a clearly identifiable mutant phenotype, but interestingly, overexpression of either ddr48 or cprp in S. cerevisiae Y16748 led to a conspicuous and comparable reduction in growth rate. This observation, combined with the known role of DDR48 proteins from a range of fungal species in nutrient starvation and stress responses, raises the possibility that this family of proteins plays a role in triggering oligotrophic growth. Localization studies via the production of a Cprp:GFP fusion protein in C. passeckerianus showed clear localization adjacent to the hyphal septa and, to a lesser extent, cell walls, which is consistent with the identification of DDR48 as a cell wall-associated protein in various yeast species. To our knowledge this is the first study demonstrating that a DDR48-like protein plays a role in the regulation of a secondary metabolite, and represents the first DDR48-like protein from a basidiomycete. Potential homologs can be identified across much of the Dikarya, suggesting that this unusual protein may play a central role in regulating both primary and secondary metabolism in fungi.

Post-Traumatic Stress Disorder (PTSD) Effect of Coronavirus (COVID-19) Pandemic and Role of Emotional Intelligence

Uncommon events during different decades and centuries create several challenges in the human lifestyle. Truthfully, individuals with any circumstances that have been occurred throughout their life illustrate various reactions and behaviours. In some cases, they report some issues such as Post-Traumatic Stress Disorder (PTSD) that is related to mental health which affected by any type of natural disasters, sickness, close relative dead, war, etc. At present, one of the crucial pandemic disasters caused by worldwide disease and death rates amongst individuals is Coronavirus (Covid-19) that has been spread enormous worries and anxiety in every society and country. The majority of individuals experienced this disaster and some of them demonstrate dissimilar types of anxiety and PTSD. The current literature review attempts to clarify the relation between Coronavirus (COVID-19) and PTSD based on the most recent investigations and reports, then link them to the role of Emotional Intelligence in reducing diverse unusual stress and severe nervousness such as PTSD that is the consequence of Coronavirus (COVID-19).

Managing a patient with globus pharyngeus

A woman aged 47 years reported the feeling of a lump in her throat for the past year. The sensation was present intermittently and usually improved when she ate. She noted it was worse with dry swallows when she felt like a tablet was stuck in her throat. The sensation had become more persistent in recent weeks leading her to worry that she had cancer. She had no cough, sore throat or hoarseness. There were no precipitating factors and no symptoms of weight loss, dysphagia, odynophagia or change in her voice. She had smoked previously and rarely had heartburn. She had no other anxieties and was not under any unusual stress. She was initially assessed by an ear, nose and throat surgeon, who found no abnormalities on examination of her neck, throat and oral cavity. Nasolaryngoscopy was normal. An upper gastrointestinal endoscopy was organised and reported a hiatus hernia, but a 3-month trial of a proton pump inhibitor did not have any impact on her symptoms. The benign nature of her symptoms was discussed at her gastroenterology follow-up appointment. She was discharged back to primary care with a final diagnosis of ’globus'. A trial of speech therapy, cognitive behavioural therapy or amitriptyline would be recommended if her symptoms became more troublesome in future.