Stochastic Knapsack Revisited: The Service Level Perspective

A key challenge in the resource allocation problem is to find near-optimal policies to serve different customers with random demands/revenues, using a fixed pool of capacity (properly configured). Three classes of allocation policies, responsive (with perfect hindsight), adaptive (with information updates), and anticipative (with forecast information) policies, are widely used in practice. We analyze and compare the performances of these policies for both capacity minimization and revenue maximization models. In both models, the performance gaps between optimal anticipative policies and adaptive policies are shown to be bounded when the demand and revenue of each item are independently generated. In contrast, the gaps between the optimal adaptive policies and responsive policies can be arbitrarily large. More importantly, we show that the techniques developed, and the persistency values obtained from the optimal responsive policies can be used to design good adaptive and anticipative policies for the other two variants of resource allocation problems.

Greater visual working memory capacity for visually-matched stimuli when they are recognized as meaningful

Almost all models of visual working memory assume it has a fixed capacity: some models propose a limit of 3-4 objects, where others propose there is a fixed pool of resources for each basic visual feature. Recent findings, however, suggest that memory performance is improved for real-world objects. What supports these increases in capacity? Here, we test whether the meaningfulness of a stimulus alone influences working memory capacity while controlling for visual complexity and directly assessing the active component of working memory using EEG. Participants remembered ambiguous stimuli that could either be perceived as a face or as meaningless shapes. Participants had higher performance and increased neural delay activity when the memory display consisted of more meaningful stimuli and when they subjectively perceived the stimuli as meaningful. Thus, there are genuine increases in working memory capacity that arise from the subjective perception of the stimulus as meaningful.

Competing for Foreign Direct Investment

This article explores the effects of locally adopted economic development zones and government spending promoting foreign affairs on foreign direct investment (FDI)–related employment in Chinese provinces. While these policies are motivated by a desire for employment growth, empirical evidence supporting their effectiveness has proven elusive. Using data from Chinese provinces covering 1999 to 2012, we explore this relationship using a dynamic system generalized method of moments approach. We find some evidence that trade zones enhance FDI-related employment but find none to support the idea that industrial development zones and spending to promote foreign affairs increase employment. Conversely, regional spillovers are consistently found to increase FDI-related employment in our main results and all robustness checks. We argue this highlights the importance of crowd-out effects and agglomeration spillovers, and that coordinating FDI promotion policy across regions may compare favorably to the current approach, which mainly encourages local competition over a largely fixed pool of aggregate FDI.

Oogonial stem cells as a model to study age-associated infertility in women

Fertility is the first biological process to break down during aging, thereby making it a useful tool to understand fundamental processes of aging. Reproductive aging in females is associated with a loss of ovarian function characterised by a reduction in the number and quality of oocytes. The central dogma, namely that females are born with a fixed pool of oocytes that progressively decline with increasing maternal age, has been challenged by evidence supporting postnatal oogenesis in mammals. Reports demonstrating formation of new oocytes from newly discovered germline stem cells, referred to as oogonial stem cells (OSCs), has opened new avenues for treatment of female infertility. In this review we discuss why the OSCs possibly lose their regenerative potential over time, and focus specifically on the aging process in germline stem cells as a possible mechanism for understanding female age-related infertility and how we can slow or delay ovarian aging.

Comparing Perceptual Signals of Single V5/MT Neurons in Two Binocular Depth Tasks

Neurons in the extrastriate visual area V5/MT show perceptually relevant signals in binocular depth tasks, which can be measured as a choice probability (CP) for the neuron. The presence of a CP in a particular paradigm may be an indicator that the neuron is generally part of the substrate for the perception of binocular depth. We compared the responses of those single neurons that show CPs in one stereoscopic depth task with their responses in another stereo task. Each neuron was tested for the presence of 1) CPs during a task in which macaques responded to the sign of binocular depth in a structure-from-motion stimulus, to judge its direction of three-dimensional rotation and 2) a consistent response to the stereo disparity of binocularly anti-correlated stimuli. Previous work, confirmed here, shows that changing the disparity of these binocularly anti-correlated stimuli often fails to yield a coherent change in the depth percept. For each test alone, there are V5/MT neurons that carry signals that are congruent with the perceptual effects. However, on comparing tests, there is no fixed pool of neurons that can account for the binocular depth percept. Excitation of neurons with a measurable CP does not necessarily lead to a change in perception. The cortical circuitry must be able to make dynamic changes in the pools of neurons that underlie perceptual judgments according to the demands of the task.

Transferrin and iron release from rat hepatocytes in culture

The regulation of transferrin and iron release from the liver was studied using adult rat hepatocytes in primary monolayer culture. The cells were prelabeled by incubation with rat transferrin doubly labeled with iodine-125 and iron-59. Approximately 50% of the 125I-transferrin but only 10% of the iron-59 taken up by the cells was released during reincubation for 24 h. Less than 10% of the refluxed transferrin was catabolized as indicated by the protein-free iodine-125 values. These results suggest that at least part of iron uptake by hepatocytes is mediated by the reversible binding of transferrin in a manner comparable with erythroid cells and placenta. However, several iron chelators mobilized hepatic iron, in contrast to erythroid cells. Apotransferrin and desferrioxamine released a maximum of about 20% iron-59 with little effect on transferrin binding. A greater proportion of the iron-59 was available for chelation after shorter uptake times (1-2 h) than longer times. Hence, there are at least three iron compartments in hepatocytes in culture: rapidly refluxing iron that may be transferrin bound, a fixed pool, and a chelatable pool that may represent iron in transit between plasma transferrin and ferritin.