The food additive fast green FCF inhibits α‑synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity

α-Synuclein (α-syn) aggregates into cytotoxic amyloid fibrils, which are recognized as the defining neuropathological feature of Parkinson’s disease (PD). Therefore, inhibiting α-syn fibrillogenesis and disrupting the preformed fibrils are both...

PENDIDIKAN UNTUK MASYARAKAT TENTANG BAHAYA PEWARNA MELALUI PUBLIKASI HASIL ANALISIS KUALITATIF PEWARNA SINTETIS DALAM SAUS

Keberhasilan dari konsep analisis kualitatif pewarna ini sangat ditentukan oleh proses penerapan ilmu dalam bidang analisis farmasi dan makanan, untuk diaplikasikan kepada masyarakat, dalam hal pewarna sintetis, yang merupakan pewarna yang diizinkan yang ditambahakan dalam produk pangan, Pewarna sintetis yang diizinkan seperti Tartrazine, Sunset yellow FCF, Ponceau 4R, Eritromisin, Brillint Blue FCF, Fast green FCF, Brown HT, dan pewarna sintetis yang tidak diizinkan seperti Rhodamin B dan Methanil Yellow. Pewarna sintetis pada makanan dapat mengakibatkan iritasi pada saluran pencernaan dan mengakibatkan gejala keracunan.Tujuan penelitian ini adalah untuk mengetahui analisis kualitatif pewarna sintetis serta dapat membantu dalam pengawasan saus yang beredar di Banda Aceh. Jenis penelitian yang digunakan kualitatif dan sampel dianalisis menggunakan metode kromatografi lapis tipis dengan menggunakan dua eluen yang berbeda yang dideteksi dengan lampu UV pada 254nm. Adapun yang menjadi hasil penelitian ini adalah satu sampel positif mengandung Rhodamin B sedangkan ketiga sampel mengandung Ponceau 4R.

The Electrochemical Variation of a Kind of Protein Staining and Food Dye as a New Corrosion Inhibitor on Mild Steel in Acidic Medium

In this study, the relevance of a food dye, namely, Fast Green-FCF (FG-FCF), was surveyed as a new inhibitor for mild steel in HCl solution. This effect was specified by electrochemical impedance spectroscopy (EIS), one of the most widely used measurement techniques. As a result of the increment of the inhibitor concentration, it was seen that the values ​​of polarization resistance increased and covered the metal surface of FG-FCF like a blanket. Tests endorse that the FG-FCF is chemically adsorbed on mild steel surface, according to the Langmuir isotherm. With surface characteristic analyses, such as field emission scanning electron microscope (FESEM) and atomic force microscope (AFM), it was further determined that the metal surface in HCl of FG-FCF was protected. By applying the hydrogen gas evolution technique, FG-FCF has been proven to provide the lowest surface area with all inhibited solutions from the blank due to its strong adsorption to the metal surface. Finally, it has been clarified that FG-FCF can be practically used as a good corrosion inhibitor for mild steel with the supported results.