Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma

AbstractBackgroundIn the present era, obesity is increasing rapidly, and high dietary intake of lipid could be a noteworthy risk factor for the occasion of obesity, as well as nonalcoholic fatty liver disease, which is the independent risk factor for type 2 diabetes and cardiovascular disease. For a long time, high-lipid diet (HLD) in “fast food” is turning into part of our everyday life. So, we were interested in fulfilling the paucity of studies by means of preliminary evaluation of these three alternative doses of HLD on a rat model and elucidating the possible mechanism of these effects and divulging the most alarming dose.MethodsThirty-two rats were taken, and of these, 24 were fed with HLD in three distinctive compositions of edible coconut oil and vanaspati ghee in a ratio of 2:3, 3:2 and 1:1 (n = 8), orally through gavage at a dose of 10 mL/kg body weight for a period of 28 days, whereas the other eight were selected to comprise the control group.ResultsAfter completion of the experiment, followed by analysis of data it was revealed that hyperlipidemia with increased liver and cardiac marker enzymes, are associated with hepatocellular injury and cardiac damage. The data also supported increased proinflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α). As oxidative stress parameter increased in both liver and heart, there is also an increased in TNF-α due to an increased expression of inducible nitric oxide (NO) synthase, which led to a high production of NO. Moreover, HLD treatment explicitly weakens reasonability of hepatocytes and cardiomyocytes conceivably through G0/G1 or S stage capture or perhaps by means of enlistment of sub-G0/G1 DNA fragmentation and a sign of apoptosis.ConclusionsBased on the outcomes, it tends to be inferred that consequences of the present examination uncovered HLD in combination of 2:3 applies most encouraging systemic damage by reactive oxygen species generation and hyperlipidemia and necroapoptosis of the liver and heart. Hence, outcome of this study may help to formulate health care strategy and warns about the food habit in universal population regarding the use of hydrogenated and saturated fats (vanaspati ghee) in diet.

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Effect of high lipid diet on circadian rhythms of tissue glycogen

Cellular and Molecular Life Sciences ◽

10.1007/bf01965984 ◽

1980 ◽

Vol 36 (9) ◽

pp. 1085-1086 ◽

Cited By ~ 2

Author(s):

Susan M. Garthwaite ◽

D. K. Meyer

Keyword(s):

Circadian Rhythms ◽

High Lipid ◽

High Lipid Diet ◽

Lipid Diet

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Mechanistic study of attenuation of monosodium glutamate mixed high lipid diet induced systemic damage in rats by Coccinia grandis

Scientific Reports ◽

10.1038/s41598-020-72076-6 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Arnab Banerjee ◽

Debasmita Das ◽

Rajarshi Paul ◽

Sandipan Roy ◽

Ujjal Das ◽

...

Keyword(s):

Monosodium Glutamate ◽

Ethanol Extract ◽

Inflammatory Factors ◽

Mechanistic Study ◽

Metabolic Disturbances ◽

Alcoholic Fatty Liver ◽

Coccinia Grandis ◽

High Lipid ◽

High Lipid Diet ◽

Lipid Diet

Abstract In the context of failure of treatment for non alcoholic fatty liver disease (NAFLD)-mediated systemic damages, recognition of novel and successful characteristic drug to combat these anomalous situations is earnestly required. The present study is aimed to evaluate protective value of ethanol extract of Coccinia grandis leaves (EECGL), naturally occurring medicinal plant, on NAFLD-mediated systemic damage induced by high lipid diet along with monosodium glutamate (HM)-fed rats. Our study uncovered that EECGL significantly ameliorates HM-induced hyperlipidemia, increased lipogenesis and metabolic disturbances (via up regulation of PPAR-α and PPAR-γ), oxidative stress (via reducing the generation of reactive oxygen species and regulating the redox-homeostasis) and inflammatory response (via regulating the pro-inflammatory and anti-inflammatory factors with concomitant down regulation of NF-kB, iNOS, TNF-α and up regulation of eNOS). Furthermore, EECGL significantly inhibited HM-induced increased population of cells in sub G0/G1 phase, decreased Bcl2 expression and thereby loss of mitochondrial membrane potential with over expression of Bax, p53, p21, activation of caspase 3 and 9 indicated the apoptosis and suppression of cell survival. It is perhaps the first comprehensive study with a mechanistic approach which provides a strong unique strategy for the management of HM-induced systemic damage with effective dose of EECGL.

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Hypercaloric high-lipid diet and brain development: Effects on cortical spreading depression in adult rats

Nutritional Neuroscience ◽

10.1179/1476830513y.0000000056 ◽

2013 ◽

Vol 16 (6) ◽

pp. 275-281 ◽

Cited By ~ 1

Author(s):

Paula Catirina Pereira da Silva Germano ◽

Débora de Lima e Silva ◽

Geórgia de Sousa Ferreira Soares ◽

Ângela Amâncio dos Santos ◽

Rubem Carlos Araújo Guedes

Keyword(s):

Brain Development ◽

Cortical Spreading Depression ◽

Spreading Depression ◽

Adult Rats ◽

High Lipid ◽

High Lipid Diet ◽

Lipid Diet

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Hypolipidemic effects of garlic oil in rats fed ethanol and a high lipid diet

Cellular and Molecular Life Sciences ◽

10.1007/bf01947571 ◽

1984 ◽

Vol 40 (3) ◽

pp. 261-263 ◽

Cited By ~ 32

Author(s):

A. Shoetan ◽

K. T. Augusti ◽

P. K. Joseph

Keyword(s):

Garlic Oil ◽

High Lipid ◽

High Lipid Diet ◽

Lipid Diet

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Effect of an aqueous extract of annatto (Bixa orellana) seeds on lipid profile and biochemical markers of renal and hepatic function in hipercholesterolemic rats

Brazilian Archives of Biology and Technology ◽

10.1590/s1516-89132009000600008 ◽

2009 ◽

Vol 52 (6) ◽

pp. 1373-1378 ◽

Cited By ~ 6

Author(s):

Heberth de Paula ◽

Maria Lúcia Pedrosa ◽

Joamyr Victor Rossoni Júnior ◽

Fabiano Kenji Haraguchi ◽

Rinaldo Cardoso dos Santos ◽

...

Keyword(s):

Lipid Profile ◽

Hdl Cholesterol ◽

Serum Levels ◽

Hepatic Function ◽

Natural Food ◽

Standard Diet ◽

Bixa Orellana ◽

High Lipid ◽

High Lipid Diet ◽

Lipid Diet

Annatto extract is a natural food color obtained from the outer coatings of the seeds of the Annatto tree (Bixa orellana L.). This is the first report in the literature that shows the relationship between the aqueous annatto extract and its influence on lipid profile in animals. Male Fisher rats were divided into three groups (n=12): C group, fed standard diet and water; H group, fed high-lipid diet and water and; HU group, with high-lipid diet and aqueous annatto extract for 60 days. The treatment with annatto extract in animals fed with the high-lipid diet lowered the LDL- and total cholesterol and raised the HDL-cholesterol, suggesting a hypocholesterolemic effect. Neither high-fat diet nor aqueous annatto extract had any significant effect on serum levels of albumin or serum activities of transaminases which suggested that no liver injury was induced.

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Modulatory Effects of Some Fruit Juices on Lipid Profile in Rats Fed with High Lipid Diet

Asian Journal of Biochemistry, Genetics and Molecular Biology ◽

10.9734/ajbgmb/2020/v3i230079 ◽

2020 ◽

pp. 1-8

Author(s):

Habibu Tijjani ◽

Enoch Banbilbwa Joel ◽

Carrol Domkat Luka

Keyword(s):

Lipid Profile ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Fruit Juices ◽

Atherogenic Index ◽

Ananas Comosus ◽

Low Density ◽

High Lipid ◽

High Lipid Diet ◽

Lipid Diet

Background: Hyperlipidemia is a predisposing factor to several cardiovascular diseases, including atherosclerosis, myocardial infarction, heart attacks and others. Aim: This study investigate the hypolipidemic properties of five selected fruits using rats pre-fed with High Lipid Diet (HLD) under experimental conditions. Methods: Raw fruit juices from Guava (Psidium guajava), Pawpaw (Carica papaya), Banana (Musa acuminata), Apple (Pyrus malus) and Pineapple (Ananas comosus) respectively, were administered orally at a dose of 7 ml/kg body weight for 14 days. Sera from the experimental rats were prepared for total cholesterol (TC), triglyceride (TG), High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL) assay, while Very Low Density Lipoprotein (VLDL) and Atherogenic Index (AI) were computed. Results: Feeding the experimental rats with High Lipid Diet increased their levels of TC, TG, LDL, VLDL and AI by 68.73%, 72.94%, 20.23%, 71.79% and 208.72% respectively with a corresponding decrease in HDL by 29.47%. Pineapple juice significantly reduced the levels of TC, TG, LDL, VLDL and AI by 84.44%, 69.39%, 95.19%, 70.15% and 96.99% respectively. Guava, banana and apple treated groups produced 56.72%, 23.88% and 07.46% increase in HDL respectively, with a non-significant (p<0.05) value in pawpaw treated group, when compared to the HLD untreated control. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, cardiac glycosides, terpenes and steroids in all fruit juices and the absence of balsams and phenols. Conclusion: Consumption of the selected fruit juices improved lipid profile and reduced the risk associated with hyperlipidemia in experimental rats.

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