Effect of Tomato Juice Supplements Consumption on the Lipid Profile of Dyslipidemia Patients

The objective of this study was to determine the effect of tomato juice supplements consumption on the lipid profile of women with dyslipidemia patients. The design of this study was a quasi-control experimental design with pre-post test. The subjects were sixty-two Kendal Hospital women employees, aged 35–50 years old, suffering from dyslipidemia but did not suffer from metabolic or degenerative diseases based on the examination of a specialist in internal medicine. Subjects were divided into two groups, group I (30 people) were given antioxidant supplements (336 g of tomatoes per day) for 21 days and group II (32 people) as control. The nutrition intake data was measured by the 24-hour food withdrawal method conducted for three consecutive days in three weeks of research calculated by the Nutrisurvey program. Data was analyzed with Kolmogorov Smirnov test, Pearson test and Mann Whitney test. There were significant relationships between energy intake, protein intake, fat intake, and carbohydrate intake with total cholesterol levels and triglyceride levels and there were also significant relationships between energy intake and fat intake with low density lipoprotein levels. It shows that there is a relationship between diet and dyslipidemia. There were significant differences in total cholesterol, low lipoprotein levels and triglycerides in treatment and control groups. This showed that tomato juice supplements significantly affect the lipid profiles.

Dyslipidemia and Endocrine Disorder

Dyslipidemia is one of the most common risk factors for the most prevalent and fatal non-communicable diseases (NCDs); cardiovascular disease (CVD), cancer, chronic respiratory disease and diabetes and other. According to world health organization (WHO) report effective management of dyslipidemia can reduce incidence and mortality rate by NCDs up to 30%. Dyslipidemia negatively affects every vital organ; liver, kidney, heart, brain, lung and others in number of ways. In short dyslipidemia is defined as disorder of lipoprotein metabolism and it could be either hypolipoproteinemia or hyperlipoproteinemia. Endocrine disorder, poor feeding habit, physical inactivity and other factors are responsible for existence of dyslipidemia. Lipocrinology which studies about interrelationship between lipid metabolism and endocrine function in normal and abnormal condition is getting essential. Currently number of studies explain that dyslipidemia induce endocrine dysfunction and the reverse is also possible. In addition, biochemical assessment of dyslipidemia is used to monitor clinical course and progress of endocrinological diseases. Similarly, biochemical analysis of hormones helps to assess the outcome of antidyslipidemic drugs and prognoses the condition dyslipidemia. Most commonly dyslipidemia coexist with type 2 diabetes, obesity and metabolic syndrome. Abnormal distribution and accumulation fat in the body leads to deranged different hormones and factors secretion like adipokine, thereby contributing to chronic inflammation and lipotoxicity. Therefore, detailed and up-to-date review about lipid metabolism disorder and endocrine function are so essential in medicine and health science to have good service to community.

Dyslipidemia: Current Perspectives and Implications for Clinical Practice

Dyslipidemia refers to a broad spectrum of various genetic and acquired disorders that affect blood lipid levels and largely contribute to global cardiovascular disease burden. Consistent evidence from epidemiological and clinical studies, supports the key role of the circulating LDL-cholesterol and other apoB containing lipoproteins in atherogenesis. All ApoB-containing lipoproteins with size less than 70 nm can cross the endothelial barrier, particularly in the presence of endothelial dysfunction. Uptake and accumulation of apoB-containing lipoproteins in the arterial wall is a critical initiating event in the development of atherosclerosis. Statin treatment, targeting LDL cholesterol reduction, remains the cornerstone of dyslipidemia management. There are abundant data supporting the concept of ‘the lower LDL-C, the better’ in the primary and secondary cardiovascular disease prevention. This chapter provides an overview of the key insights into the lipid abnormalities associated with an increased risk of CV events particulary in the context of dyslipidemia management in everyday clinical practice. Understanding the important role that metabolic derangements play in the pathogenesis of atherosclerosis pave the way for stronger implementation of current guidelines for CVD risk assessment and prevention.